アルカン1-モノオキシゲナーゼ
- 関
- CYP4A
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/05 18:48:09」(JST)
[Wiki en表示]
| alkane 1-monooxygenase |
| Identifiers |
| EC number |
1.14.15.3 |
| CAS number |
9059-16-9 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, an alkane 1-monooxygenase (EC 1.14.15.3) is an enzyme that catalyzes the chemical reactions
- an alkane + reduced rubredoxin + O2 a primary alcohol + oxidized rubredoxin + H2O.
Alkanes of 6 to 22 carbons have been observed as substrates.[1] This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with oxygen as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor. The systematic name of this enzyme class is alkane, reduced-rubredoxin:oxygen 1-oxidoreductase. Other names in common use include alkane 1-hydroxylase, omega-hydroxylase, fatty acid omega-hydroxylase, alkane monooxygenase, 1-hydroxylase, AlkB, and alkane hydroxylase. It contains a diiron non-heme active site.
References
- ^ McKenna EJ, Coon MJ (1970). "Enzymatic omega-oxidation. IV. Purification and properties of the omega-hydroxylase of Pseudomonas oleovorans". J. Biol. Chem. 245 (15): 3882–9. PMID 4395379.
- Cardini G, Jurtshuk P (1970). "The enzymatic hydroxylation of n-octane by Corynebacterium sp strain 7E1C". J. Biol. Chem. 245 (11): 2789–96. PMID 4317878.
- Peterson JA, Kusunose M, Kusunose E, Coon MJ (1967). "Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation". J. Biol. Chem. 242 (19): 4334–40. PMID 4294330.
UpToDate Contents
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English Journal
- Complete Genome Sequence of Sedimenticola thiotaurini Strain SIP-G1, a Polyphosphate- and Polyhydroxyalkanoate-Accumulating Sulfur-Oxidizing Gammaproteobacterium Isolated from Salt Marsh Sediments.
- Flood BE1, Jones DS2, Bailey JV2.
- Genome announcements.Genome Announc.2015 Jun 18;3(3). pii: e00671-15. doi: 10.1128/genomeA.00671-15.
- We report the closed genome sequence of Sedimenticola thiotaurini strain SIP-G1 and an unnamed plasmid obtained through PacBio sequencing with 100% consensus concordance. The genome contained several distinctive features not found in other published Sedimenticola genomes, including a complete nitrog
- PMID 26089430
- Defective renal dopamine function and sodium-sensitive hypertension in adult ovariectomized Wistar rats: role of the cytochrome P-450 pathway.
- Di Ciano LA1, Azurmendi PJ1, Colombero C2, Levin G2, Oddo EM1, Arrizurieta EE3, Nowicki S2, Ibarra FR4.
- American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2015 Jun 15;308(12):F1358-68. doi: 10.1152/ajprenal.00450.2014. Epub 2015 Apr 29.
- We have previously shown that ovariectomy in adult Wistar rats under normal sodium (NS) intake results in an overexpression of the total Na(+)-K(+)-ATPase (NKA) α1-subunit (Di Ciano LA, Azurmendi PJ, Toledo JE, Oddo EM, Zotta E, Ochoa F, Arrizurieta EE, Ibarra FR. Clin Exp Hypertens 35: 475-483, 20
- PMID 25925257
- Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.
- Fan F1, Geurts AM2, Murphy SR1, Pabbidi MR1, Jacob HJ2, Roman RJ3.
- American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2015 Mar 1;308(5):R379-90. doi: 10.1152/ajpregu.00256.2014. Epub 2014 Dec 24.
- We have reported that a reduction in renal production of 20-HETE contributes to development of hypertension in Dahl salt-sensitive (SS) rats. The present study examined whether 20-HETE production is also reduced in the cerebral vasculature of SS rats and whether this impairs the myogenic response an
- PMID 25540098
Japanese Journal
- Biotransformation of Various Alkanes Using the Escherichia coli Expressing an Alkane Hydroxylase System from Gordonia sp. TF6
- Bioscience, biotechnology, and biochemistry 68(10), 2171-2177, 2004-10-23
- NAID 130000030959
Related Links
- Catalyzes the hydroxylation of n-alkanes in the presence of a NADH-rubredoxin reductase and rubredoxin. ... « Hide 10 20 30 40 50 MNGKSSVLDS APEYVDKKKY FWILSTFWPA TPMIGIWLAN ETGWGIFYGL 60 70 80 90 100 ...
- MiFuP is a database of functional potentials deduced from microbial genomes. ... METAL 143 Iron 1 (By similarity). METAL 147 Iron 1 (By similarity). METAL 173 Iron 1 (By similarity). METAL 177 Iron 1 (By similarity). METAL 178
★リンクテーブル★
[★]
- 関
- alkane 1-monooxygenase
[★]
- 英
- alkane 1-monooxygenase
- 関
- CYP4Aタンパク質
[★]
- 関
- See also Cytochrome P450 system
[★]
モノオキシゲナーゼ