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English Journal

Drug metabolism enzymes in a steatotic model of rat treated with a high fat diet and a low dose of streptozotocin.

Vornoli A1, Pozzo L2, Della Croce CM2, Gervasi PG1, Longo V3.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2014 Aug;70:54-60. doi: 10.1016/j.fct.2014.04.042. Epub 2014 May 9.
Herein we have characterized CYPs and antioxidant enzymes in a new steatotic rat model induced with a high fat diet (HFD) combined with a low dose of streptozotocin (STZ). This model was recently put forward in order to better replicate the NAFLD human pathology. HFD/STZ rats developed hyperglycemia
PMID 24815820

Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl Salt-sensitive rats.

Ge Y1, Murphy SR2, Fan F3, Williams JM3, Falck JR4, Liu R3, Roman RJ5.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2014 Jul 9. pii: ajprenal.00273.2014. [Epub ahead of print]
Previous studies have indicated that a deficiency in the renal formation of 20-hydroxyeicosatetraenoic acid (20-HETE) in Dahl S (SS) rats contributes to the development of hypertension. The present study examined whether 20-HETE production is also reduced in the renal vasculature and if the defect i
PMID 25007877

Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition.

Zhang Y1, Hoda MN1, Zheng X2, Li W3, Luo P4, Maddipati KR5, Seki T1, Ergul A1, Wang MH6.
American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2014 Jul 2. pii: ajpregu.00422.2013. [Epub ahead of print]
20-Hydroxyeicosatetraenoic acid (20-HETE), Cyp4a-derived eicosanoid, is a lipid mediator that promotes tumor growth as well as causing detrimental effects in cerebral circulation. We determined whether concurrent inhibition of cyclooxygenase-2 (COX-2) and 20-HETE affects colon tumor growth and ische
PMID 24990856