(病名)失感情症

関: affective symptom、alexithymic、emotional disturbance

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/26 16:51:58」(JST)

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Alexithymia /ˌeɪlɛksəˈθaɪmiə/ is a personality construct characterized by the sub-clinical inability to identify and describe emotions in the self.^[1] The core characteristics of alexithymia are marked dysfunction in emotional awareness, social attachment, and interpersonal relating.^[2] Furthermore, individuals suffering from alexithymia also have difficulty in distinguishing and appreciating the emotions of others, which is thought to lead to unempathic and ineffective emotional responding.^[2] Alexithymia is prevalent in approximately 10% of the general population and is known to be comorbid with a number of psychiatric conditions.^[3]

The term "alexithymia" was coined by psychotherapist Peter Sifneos in 1973.^[4]^[5] According to the Oxford English Dictionary, the word comes from the Greek words λέξις (lexis, "speech") and θυμός (thumos, "soul, as the seat of emotion, feeling, and thought") modified by an alpha privative, literally meaning "no words for emotions".

Classification

Alexithymia is considered to be a personality trait that places individuals at risk for other medical and psychiatric disorders while reducing the likelihood that these individuals will respond to conventional treatments for the other conditions.^[6] Alexithymia is not classified as a mental disorder in the DSM-IV. It is a dimensional personality trait that varies in severity from person to person. A person's alexithymia score can be measured with questionnaires such as the Toronto Alexithymia Scale (TAS-20), the Bermond-Vorst Alexithymia Questionnaire (BVAQ),^[7] the Online Alexithymia Questionnaire (OAQ-G2)^[8] or the Observer Alexithymia Scale (OAS).^[6]

Alexithymia is defined by:^[9]

difficulty identifying feelings and distinguishing between feelings and the bodily sensations of emotional arousal
difficulty describing feelings to other people
constricted imaginal processes, as evidenced by a scarcity of fantasies
a stimulus-bound, externally oriented cognitive style.

In studies of the general population the degree of alexithymia was found to be influenced by age, but not by gender; the rates of alexithymia in healthy controls have been found at: 8.3%; 4.7%; 8.9%; and 7% . Thus, several studies have reported that the prevalence rate of alexithymia is less than 10%.^[10] A less common finding suggests that there may be a higher prevalence of alexithymia amongst males than females, which may be accounted for by difficulties some males have with "describing feelings", but not by difficulties in "identifying feelings" in which males and females show similar abilities.^[11]

Psychologist R. Michael Bagby and psychiatrist Graeme J. Taylor have argued that the alexithymia construct is strongly related (negatively) to the concepts of psychological mindedness^[12] and emotional intelligence^[13]^[14] and there is "strong empirical support for alexithymia being a stable personality trait rather than just a consequence of psychological distress".^[15] Other opinions differ and can show evidence that it may be state-dependent.^[16]

Bagby and Taylor also suggest that there may be two kinds of alexithymia, "primary alexithymia" which is an enduring psychological trait that does not alter over time, and "secondary alexithymia" which is state-dependent and disappears after the evoking stressful situation has changed. These two manifestations of alexithymia are otherwise called "trait" or "state" alexithymia.^[15]

Description

Typical deficiencies may include problems identifying, describing, and working with one's own feelings, often marked by a lack of understanding of the feelings of others; difficulty distinguishing between feelings and the bodily sensations of emotional arousal;^[4] confusion of physical sensations often associated with emotions; few dreams or fantasies due to restricted imagination; and concrete, realistic, logical thinking, often to the exclusion of emotional responses to problems. Those who have alexithymia also report very logical and realistic dreams, such as going to the store or eating a meal.^[17] Clinical experience suggests it is the structural features of dreams more than the ability to recall them that best characterizes alexithymia.^[4]

Some alexithymic individuals may appear to contradict the above-mentioned characteristics because they can experience chronic dysphoria or manifest outbursts of crying or rage.^[18]^[19]^[20] However, questioning usually reveals that they are quite incapable of describing their feelings or appear confused by questions inquiring about specifics of feelings.^[9]

According to Henry Krystal, individuals suffering from alexithymia think in an operative way and may appear to be superadjusted to reality. In psychotherapy, however, a cognitive disturbance becomes apparent as patients tend to recount trivial, chronologically ordered actions, reactions, and events of daily life with monotonous detail.^[21]^[22] In general, these individuals lack imagination, intuition, empathy, and drive-fulfillment fantasy^{[clarification needed]}, especially in relation to objects. Instead, they seem oriented toward things and even treat themselves as robots. These problems seriously limit their responsiveness to psychoanalytic psychotherapy; psychosomatic illness or substance abuse is frequently exacerbated should these individuals enter psychotherapy.^[9]

A common misconception about alexithymia is that affected individuals are totally unable to express emotions verbally and that they may even fail to acknowledge that they experience emotions. Even before coining the term, Sifneos (1967) noted patients often mentioned things like anxiety or depression. The distinguishing factor was their inability to elaborate beyond a few limited adjectives such as "happy" or "unhappy" when describing these feelings.^[23] The core issue is that alexithymics have poorly differentiated emotions limiting their ability to distinguish and describe them to others.^[4] This contributes to the sense of emotional detachment from themselves and difficulty connecting with others, making alexithymia negatively associated with life satisfaction even when depression and other confounding factors are controlled for.^[24]

Causes

It is unclear what causes alexithymia, though several theories have been proposed. There is evidence both for a genetic basis, meaning some people are predisposed to develop alexithymia, as well as for environmental causes.

Early studies showed evidence that there may be an interhemispheric transfer deficit among alexithymics; that is, the emotional information from the right hemisphere of the brain is not being properly transferred to the language regions in the left hemisphere, as can be caused by a decreased corpus callosum, often present in psychiatric patients who have suffered severe childhood abuse.^[25] A neuropsychological study in 1997 indicated that alexithymia may be due to a disturbance to the right hemisphere of the brain, which is largely responsible for processing emotions.^[26] In addition, another neuropsychological model suggests that alexithymia may be related to a dysfunction of the anterior cingulate cortex.^[27] These studies have some shortcomings, however, and the empirical evidence about the causes of alexithymia remains inconclusive.^[28] French psychoanalyst Joyce McDougall objected to the strong focus by clinicians on neurophysiological at the expense of psychological explanations for the genesis and operation of alexithymia, and introduced the alternative term "disaffectation" to stand for psychogenic alexithymia.^[29] For McDougall, the disaffected individual had at some point "experienced overwhelming emotion that threatened to attack their sense of integrity and identity", to which they applied psychological defenses to pulverize and eject all emotional representations from consciousness.^[30] A similar line of interpretation has been taken up using the methods of phenomenology.^[31]

McDougall has also noted that all infants are born unable to identify, organize, and speak about their emotional experiences (the word infans is from the Latin "not speaking"), and are "by reason of their immaturity inevitably alexithymic".^[32] Based on this fact McDougall proposed in 1985 that the alexithymic part of an adult personality could be "an extremely arrested and infantile psychic structure".^[32] The first language of an infant is nonverbal facial expressions. The parent's emotional state is important for determining how any child might develop. Neglect or indifference to varying changes in a child's facial expressions without proper feedback can promote an invalidation of the facial expressions manifested by the child. The parent's ability to reflect self-awareness to the child is another important factor. If the adult is incapable of recognizing and distinguishing emotional expressions in the child, it can influence the child's capacity to understand emotional expressions.^[4]

Although environmental, neurological, and genetic factors are each involved, the role of genetic and environmental factors for developing alexithymia is still unclear.^[33] The results from a large population-based sample of Danish twins suggested that genetic factors contributed noticeably to the development of alexithymia. While the results suggested a moderate influence of environmental factors that were shared between twin pairs, the authors found that non-shared environmental influences had the greatest impact on psychological traits, which was consistent with earlier findings.^{[further explanation needed]}^[33] One hypothesized environmental cause is head injury; persons suffering a traumatic brain injury are six times more likely to exhibit alexithymia.^[34]

Interpersonal relationship issues

Alexithymia creates interpersonal problems because these individuals tend to avoid emotionally close relationships, or if they do form relationships with others they usually position themselves as either dependent, dominant, or impersonal, "such that the relationship remains superficial".^[35] Inadequate "differentiation" between self and others by alexithymic individuals has also been observed.^[36]^[37]

In a study, a large group of alexithymic individuals completed the 64-item Inventory of Interpersonal Problems (IIP-64) which found that "two interpersonal problems are significantly and stably related to alexithymia: cold/distant and non-assertive social functioning. All other IIP-64 subscales were not significantly related to alexithymia."^[35]

Chaotic interpersonal relations have also been observed by Sifneos.^[38] Due to the inherent difficulties identifying and describing emotional states in self and others, alexithymia also negatively affects relationship satisfaction between couples.^[39]

In a 2008 study^[40] alexithymia was found to be correlated with impaired understanding and demonstration of relational affection, and that this impairment contributes to poorer mental health, poorer relational well-being, and lowered relationship quality.^[40] Individuals high on the alexithymia spectrum also report less distress at seeing others in pain and behave less altruistically toward others.^[2]

Some individuals working for organizations in which control of emotions is the norm might show alexithymic-like behavior but not be alexithymic. However, over time the lack of self-expressions can become routine and they may find it harder to identify with others.^[41]

Comorbid medical and psychiatric illness

Alexithymia frequently co-occurs with other disorders. Research indicates that alexithymia overlaps with autism spectrum disorders (ASD).^[8]^[42] In a 2004 study using the TAS-20, 85% of the adults with ASD fell into the impaired category; almost half of the whole group fell into the severely impaired category. Among the normal adult control, only 17% was impaired; none of them severely.^[42]^[43] Fitzgerald & Bellgrove pointed out that, "Like alexithymia, Asperger's syndrome is also characterised by core disturbances in speech and language and social relationships".^[44] Hill & Berthoz agreed with Fitzgerald & Bellgrove (2006) and in response stated that "there is some form of overlap between alexithymia and ASDs". They also pointed to studies that revealed impaired theory of mind skill in alexithymia, neuroanatomical evidence pointing to a shared etiology and similar social skills deficits.^[45] The exact nature of the overlap is uncertain. Alexithymic traits in AS may be linked to clinical depression or anxiety;^[43] the mediating factors are unknown and it is possible that alexithymia predisposes to anxiety.^[46]

There are many more psychiatric disorders that overlap with alexithymia. One study found that 41% of Vietnam War veterans with post-traumatic stress disorder (PTSD) were alexithymic.^[47] Another study found higher levels of alexithymia among Holocaust survivors with PTSD compared to those without.^[48] Higher levels of alexithymia among mothers with interpersonal violence-related PTSD were found in one study to have proportionally less caregiving sensitivity.^[49] This latter study suggested that when treating adult PTSD patients who are parents, alexithymia should be assessed and addressed also with attention to the parent-child relationship and the child's social-emotional development.

Single study prevalence findings for other disorders include 63% in anorexia nervosa,^[50] 56% in bulimia,^[50] 45%^[16] to 50%^[51] in major depressive disorder, 34% in panic disorder,^[52] 28% of social phobics,^[52] and 50% in substance abusers.^[53] Alexithymia also occurs more frequently in individuals with acquired or traumatic brain injury.^[54]^[55]^[56]

Alexithymia is correlated with certain personality disorders,^[57] substance use disorders,^[58]^[59] some anxiety disorders,^[60] and sexual disorders,^[61] as well as certain physical illnesses, such as hypertension,^[62] inflammatory bowel disease,^[63] and functional dyspepsia.^[64] Alexithymia is further linked with disorders such as migraine headaches, lower back pain, irritable bowel syndrome, asthma, nausea, allergies, and fibromyalgia.^[65]

An inability to modulate emotions is a possibility in explaining why some alexithymics are prone to discharge tension arising from unpleasant emotional states through impulsive acts or compulsive behaviors such as binge eating, substance abuse, perverse sexual behavior, or anorexia nervosa.^[66] The failure to regulate emotions cognitively might result in prolonged elevations of the autonomic nervous system (ANS) and neuroendocrine systems which can lead to somatic diseases.^[65] Alexithymics also show a limited ability to experience positive emotions leading Krystal (1988) and Sifneos (1987) to describe many of these individuals as anhedonic.^[5]

Notes

^ Sifneos PE (1973). "The prevalence of 'alexithymic' characteristics in psychosomatic patients". Psychotherapy and psychosomatics 22 (2): 255–262. doi:10.1159/000286529.
^ ^a ^b ^c Feldman-Hall Oriel, Dalgleish Tim, Mobbs Dean. "Alexithymia decreases altruism in real social decisions". Cortex 49: 899–904. doi:10.1016/j.cortex.2012.10.015.
^ Taylor GJ, Bagby, M.R., Parker, J.D.A. Disorders of Affect Regulation: Alexithymia in Medical and Psychiatric Illness. Cambridge: Cambridge University Press, 1999
^ ^a ^b ^c ^d ^e Bar-On, Reuven; Parker, James DA (2000). The Handbook of Emotional Intelligence: Theory, Development, Assessment, and Application at Home, School, and in the Workplace. San Francisco, California: Jossey-Bass. ISBN 0-7879-4984-1. pp. 40–59
^ ^a ^b Taylor GJ & Taylor HS (1997). Alexithymia. In M. McCallum & W.E. Piper (Eds.) Psychological mindedness: A contemporary understanding. Munich: Lawrence Erlbaum Associates pp. 28–31
^ ^a ^b Haviland MG, Warren WL, Riggs ML (2000). "An observer scale to measure alexithymia". Psychosomatics 41 (5): 385–92. doi:10.1176/appi.psy.41.5.385. PMID 11015624. Retrieved 2007-08-10.
^ Vorst HCM, Bermond B (2001). "Validity and reliability of the Bermond-Vorst Alexithymia Questionnaire". Personality and Individual Differences 30 (3): 413–434. doi:10.1016/S0191-8869(00)00033-7.
^ ^a ^b Paula-Perez I (Mar 2010). "Alexitimia y sindrome de Asperger". Rev Neurol 50 (Suppl 3): S85–90.
^ ^a ^b ^c Taylor (1997), p. 29
^ Fukunishi I, Berger D, Wogan J, Kuboki T (1999). "Alexithymic traits as predictors of difficulties with adjustment in an outpatient cohort of expatriates in Tokyo". Psychological reports 85 (1): 67–77. doi:10.2466/PR0.85.5.67-77. PMID 10575975. Retrieved 2007-08-10.
^ Salminen JK, Saarijärvi S, Aärelä E, Toikka T, Kauhanen J (1999). "Prevalence of alexithymia and its association with sociodemographic variables in the general population of Finland". Journal of psychosomatic research 46 (1): 75–82. doi:10.1016/S0022-3999(98)00053-1. PMID 10088984.
^ Taylor & Taylor (1997), pp. 77–104
^ Taylor (1997), p. 38
^ Parker, JDA; Taylor, GJ; Bagby, RM (2001). "The Relationship Between Emotional Intelligence and Alexithymia". Personality and Individual Differences 30: 107–115. doi:10.1016/S0191-8869(00)00014-3.
^ ^a ^b Taylor (1997), p. 37
^ ^a ^b Honkalampi K, Hintikka J, Laukkanen E, Lehtonen J, Viinamäki H (2001). "Alexithymia and depression: a prospective study of patients with major depressive disorder". Psychosomatics 42 (3): 229–34. doi:10.1176/appi.psy.42.3.229. PMID 11351111.
^ Krystal H (1979). "Alexithymia and psychotherapy". American journal of psychotherapy 33 (1): 17–31. PMID 464164.
^ Nemiah et al. (1970), pp. 432–33
^ Krystal (1988), p. 246; McDougall (1985), pp. 169–70
^ Taylor (1997), pp. 29, 246–47
^ Krystal (1988) pp. 246-247
^ Nemiah, CJ (1978). "Alexithymia and Psychosomatic Illness". Journal of Continuing Education 39: 25–37.
^ Sifneos, PE (1967). "Clinical Observations on some patients suffering from a variety of psychosomatic diseases". Acta Medicina Psychosomatica 7: 1–10.
^ Mattila AK, Poutanen O, Koivisto AM, Salokangas RKR, Joukamaa M. "Alexithymia and Life Satisfaction in Primary Healthcare Patients". Psychosomatics 48: 523–529. doi:10.1176/appi.psy.48.6.523.
^ Hoppe KD, Bogen JE (1977). "Alexithymia in twelve commissurotomized patients". Psychotherapy and psychosomatics 28 (1–4): 148–55. doi:10.1159/000287057. PMID 609675.
^ Jessimer M, Markham R (1997). "Alexithymia: a right hemisphere dysfunction specific to recognition of certain facial expressions?". Brain and cognition 34 (2): 246–58. doi:10.1006/brcg.1997.0900. PMID 9220088.
^ Lane RD, Ahern GL, Schwartz GE, Kaszniak AW (1997). "Is alexithymia the emotional equivalent of blindsight?". Biol. Psychiatry 42 (9): 834–44. doi:10.1016/S0006-3223(97)00050-4. PMID 9347133.
^ Tabibnia G, Zaidel E (2005). "Alexithymia, interhemispheric transfer, and right hemispheric specialization: a critical review". Psychotherapy and psychosomatics 74 (2): 81–92. doi:10.1159/000083166. PMID 15741757.
^ McDougall (1989), pp. 93, 103
^ McDougall (1989), pp. 93–94
^ Maclaren K (2006). "Emotional Disorder and the Mind-Body Problem: A Case Study of Alexithymia". Chiasmi International 8: 139–55. doi:10.5840/chiasmi2006819.
^ ^a ^b McDougall (1985), p. 161
^ ^a ^b Jørgensen MM, Zachariae R, Skytthe A, Kyvik K (2007). "Genetic and Environmental Factors in Alexithymia: A Population-Based Study of 8,785 Danish Twin Pairs". Psychotherapy and Psychosomatics 76: 369–375. doi:10.1159/000107565. PMID 17917473.
^ Williams C, Wood RL (June 2009). "Alexithymia and emotional empathy following traumatic brain injury". J Clin Exp Neuropsychol 32 (3): 1–11. doi:10.1080/13803390902976940. PMID 19548166. Lay summary – Psychology Today (January 3, 2010).
^ ^a ^b Vanheule S, Desmet M, Meganck R, Bogaerts S (2007). "Alexithymia and interpersonal problems". Journal of clinical psychology 63 (1): 109–17. doi:10.1002/jclp.20324. PMID 17016830.
^ Blaustein JP, Tuber SB (1998). "Knowing the Unspeakable". Bulletin of the Menninger Clinic 62: 351–365.
^ Taylor (1997) pp. 26-46
^ Sifneos PE (1996). "Alexithymia: past and present". The American Journal of Psychiatry 153 (7 Suppl): 137–42. PMID 8659637.
^ Yelsma P, Marrow S (2003). "An Examination of Couples' Difficulties With Emotional Expressiveness and Their Marital Satisfaction". Journal of Family Communication 3 (1): 41–62. doi:10.1207/S15327698JFC0301_03.
^ ^a ^b Hesse Colin, Floyd Kory (2008). "Affectionate experience mediates the effects of alexithymia on mental health and interpersonal relationships". Journal of Social and Personal Relationships 25 (5): 793–810. doi:10.1177/0265407508096696.
^ Manfred F.R. Kets de Vries (2001) "Struggling with the Demon: Perspectives on Individual and Organizational Irrationality"
^ ^a ^b Hill E, Berthoz S, Frith U (2004). "Brief report: cognitive processing of own emotions in individuals with autistic spectrum disorder and in their relatives". Journal of Autism and Developmental Disorders 34 (2): 229–235. doi:10.1023/B:JADD.0000022613.41399.14. PMID 15162941.
^ ^a ^b Frith U (2004). "Emanuel Miller lecture: confusions and controversies about Asperger syndrome". Journal of child psychology and psychiatry, and allied disciplines 45 (4): 672–86. doi:10.1111/j.1469-7610.2004.00262.x. PMID 15056300. http://onlinelibrary.wiley.com/doi/10.1111/j.1469-7610.2004.00262.x/pdf The study to which Frith refers is the Hill E, Berthoz S, Frith U (2004) referenced before this one.
^ Fitzgerald M, Bellgrove MA (2006). "The Overlap Between Alexithymia and Asperger's syndrome". Journal of autism and developmental disorders 36 (4): 573–6. doi:10.1007/s10803-006-0096-z. PMC 2092499. PMID 16755385. Retrieved 2007-04-11.
^ Hill E, Berthoz S (May 2006). "Response to 'Letter to the Editor: The Overlap Between Alexithymia and Asperger's syndrome', Fitzgerald and Bellgrove, Journal of Autism and Developmental Disorders, 36(4)". Journal of Autism and Developmental Disorders 36 (8): 1143–1145. doi:10.1007/s10803-006-0287-7. PMID 17080269.
^ Tani P, Lindberg N, Joukamaa M, et al. (2004). "Asperger syndrome, alexithymia and perception of sleep". Neuropsychobiology 49 (2): 64–70. doi:10.1159/000076412. PMID 14981336.
^ Shipko S, Alvarez WA, Noviello N (1983). "Towards a teleological model of alexithymia: alexithymia and post-traumatic stress disorder". Psychotherapy and psychosomatics 39 (2): 122–6. doi:10.1159/000287730. PMID 6878595.
^ Yehuda R, Steiner A, Kahana B Binder-Brynes K, Southwick SM, Zemelman S, Giller EL (1997). "Alexithymia in Holocaust survivors with and without PTSD". J Trauma Stress 10 (1): 83–100.
^ Schechter DS, Suardi F, Manini A, Cordero MI, Sancho Rossignol A, Gex-Fabry Merminod G, Moser DA, Rusconi Serpa S. "How do maternal PTSD and alexithymia interact to impact maternal behaviour?". Child Psychiatry and Human Development.
^ ^a ^b Cochrane CE, Brewerton TD, Wilson DB, Hodges EL (1993). "Alexithymia in the eating disorders". The International Journal of Eating Disorders 14 (2): 219–22. doi:10.1002/1098-108X(199309)14:23.0.CO;2-G. PMID 8401555.
^ The Relationship between Alexithymia and General Symptoms of Patients with Depressive Disorders. Kim JH, Lee SJ, Rim HD, Kim HW, Bae GY, Chang SM. Psychiatry Investig. 2008 Sep; 5(3):179-85. Epub 2008 Sep 30. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796028/
^ ^a ^b Cox BJ, Swinson RP, Shulman ID, Bourdeau D (1995). "Alexithymia in panic disorder and social phobia". Comprehensive Psychiatry 36 (3): 195–8. doi:10.1016/0010-440X(95)90081-6. PMID 7648842.
^ Taylor GJ, Parker JD, Bagby RM (1990). "A preliminary investigation of alexithymia in men with psychoactive substance dependence". The American Journal of Psychiatry 147 (9): 1228–30. PMID 2386256.
^ Williams C, Wood RL (March 2010). "Alexithymia and emotional empathy following traumatic brain injury". J Clin Exp Neuropsychol 32 (3): 259–67. doi:10.1080/13803390902976940. PMID 19548166.
^ Koponen S, Taiminen T, Honkalampi K, et al. (2005). "Alexithymia after traumatic brain injury: its relation to magnetic resonance imaging findings and psychiatric disorders". Psychosom Med 67 (5): 807–12. doi:10.1097/01.psy.0000181278.92249.e5. PMID 16204442.
^ Becerra R, Amos A, Jongenelis S (July 2002). "Organic alexithymia: a study of acquired emotional blindness". Brain Inj 16 (7): 633–45. doi:10.1080/02699050110119817. PMID 12119081.
^ Schizotypal, dependent and avoidant disorders are particularly indicated: See Taylor (1997), pp. 162–165
^ Li CS, Sinha R (1 March 2006). "Alexithymia and stress-induced brain activation in cocaine-dependent men and women". Journal of psychiatry & neuroscience : JPN 31 (2): 115–21. PMC 1413961. PMID 16575427.
^ Lumley MA, Downey K, Stettner L, Wehmer F, Pomerleau OF (1994). "Alexithymia and negative affect: relationship to cigarette smoking, nicotine dependence, and smoking cessation". Psychotherapy and psychosomatics 61 (3–4): 156–62. doi:10.1159/000288884. PMID 8066152.
^ Jones BA (1984). "Panic attacks with panic masked by alexithymia" (PDF). Psychosomatics 25 (11): 858–9. doi:10.1016/S0033-3182(84)72947-1. PMID 6505131. Retrieved 2006-12-17.
^ Michetti PM, Rossi R, Bonanno D, Tiesi A, Simonelli C (2006). "Male sexuality and regulation of emotions: a study on the association between alexithymia and erectile dysfunction (ED)". Int. J. Impot. Res. 18 (2): 170–4. doi:10.1038/sj.ijir.3901386. PMID 16151475. Retrieved 2007-02-02.
^ Jula A, Salminen JK, Saarijärvi S (1 April 1999). "Alexithymia: a facet of essential hypertension". Hypertension 33 (4): 1057–61. doi:10.1161/01.HYP.33.4.1057. PMID 10205248. Retrieved 2006-12-17.
^ Verissimo R, Mota-Cardoso R, Taylor G (1998). "Relationships between alexithymia, emotional control, and quality of life in patients with inflammatory bowel disease". Psychotherapy and psychosomatics 67 (2): 75–80. doi:10.1159/000012263. PMID 9556198.
^ Jones MP, Schettler A, Olden K, Crowell MD (2004). "Alexithymia and somatosensory amplification in functional dyspepsia". Psychosomatics 45 (6): 508–16. doi:10.1176/appi.psy.45.6.508. PMID 15546828. Retrieved 2006-12-17.
^ ^a ^b Taylor (1997), pp. 216–248
^ Taylor (1997), pp. 31

References

Krystal, H (1988). Integration and Self Healing: Affect, Trauma, Alexithymia. Hillsdale, NJ: The Analytic Press. ISBN 0-88163-070-5.
Linden W, Wen F, Paulhaus DL (1994). Measuring alexithymia: reliability, validity, and prevalence. In: J. Butcher, C. Spielberger (Eds.). Advances in Personality Assessment. Hillsdale, NJ: Lawrence Erlbaum Associates.
McDougall, J (1989). Theaters of the Body: A Psychoanalytic Approach to Psychosomatic Illness, Norton.
McDougall, J (1985). Theatres of the Mind: Truth and Illusion on the Psychoanalytic Stage. New York: Basic Books. ISBN 0-946960-70-4.
Nemiah JC, Freyberger H, Sifneos PE, "Alexithymia: A View of the Psychosomatic Process" in O.W. Hill (1970) (ed), Modern Trends in Psychosomatic Medicine, Vol 2.
Taylor, Graeme J; Bagby, R. Michael; Parker, James DA (1997). Disorders of Affect Regulation: Alexithymia in Medical and Psychiatric Illness. Cambridge: Cambridge University Press. ISBN 0-521-45610-X.

External links

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1. 離人・現実感喪失障害：疫学、病因、臨床症状、経過および診断 depersonalization derealization disorder epidemiology pathogenesis clinical manifestations course and diagnosis
2. 統合失調型パーソナリティ障害：疫学、発症機序、臨床症状、経過、診断 schizotypal personality disorder epidemiology pathogenesis clinical manifestations course and diagnosis
3. 他の病状に影響を与える心理的要因：マネージメント psychological factors affecting other medical conditions management
4. 離人症性障害（離人・現実感喪失症候群）への精神療法 psychotherapy of depersonalization derealization disorder
5. 身体症状症：疫学および臨床症状 somatic symptom disorder epidemiology and clinical presentation

English Journal

Metacognitive mastery moderates the relationship of alexithymia with cluster C personality disorder traits in adults with substance use disorders.

Lysaker PH1, Olesek K2, Buck K2, Leonhardt BL3, Vohs J4, Ringer J5, Dimaggio G6, Popolo R6, Outcalt J5.Author information 1Roudebush VA Medical Center, Day Hospital 116H, 1481 West 10th St, Indianapolis, IN 46202, USA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: plysaker@iupui.edu.2Roudebush VA Medical Center, Day Hospital 116H, 1481 West 10th St, Indianapolis, IN 46202, USA.3School of Psychological Science, University of Indianapolis, Indianapolis, IN, USA.4Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA.5Roudebush VA Medical Center, Day Hospital 116H, 1481 West 10th St, Indianapolis, IN 46202, USA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA.6Center for Metacognitive Interpersonal Therapy, Rome, Italy.AbstractCluster C personality disorder traits have been observed in substance use disorders and linked with poorer outcome. One potential factor which may cause these disturbances in personality function is alexithymia, or the inability to name and express emotion. There may be other proximate factors which moderate the impact of alexithymia on the expression of cluster C traits, such as metacognitive mastery, which is the ability to use knowledge about mental states of self and others to cope with distress and solve social problems. To examine the possibility that mastery mediated the effects of alexithymia on cluster C traits, we assessed each of these constructs using the Metacognitive Assessment Scale Abbreviated, Toronto Alexithymia Scale and SCID II among 58 adults in an early phase of recovery from substance misuse disorders in a residential setting. Results of a multiple regression revealed that, after controlling for symptom severity and severity of substance misuse history, metacognitive mastery moderated the effect of alexithymia on number of cluster C traits. A median split and subsequent ANCOVA revealed that participants with higher levels of alexithymia and poorer metacognitive mastery had more cluster C traits than the other groups. These findings may have clinical implications, suggesting that patients with substance use disorders may benefit from treatment which addresses metacognitive mastery.
Addictive behaviors.Addict Behav.2014 Mar;39(3):558-61. doi: 10.1016/j.addbeh.2013.11.007. Epub 2013 Nov 10.
Cluster C personality disorder traits have been observed in substance use disorders and linked with poorer outcome. One potential factor which may cause these disturbances in personality function is alexithymia, or the inability to name and express emotion. There may be other proximate factors which
PMID 24300836

The GABA-synthetic enzyme GAD65 controls circadian activation of conditioned fear pathways.

Bergado-Acosta JR1, Müller I1, Richter-Levin G2, Stork O3.Author information 1Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University, Magdeburg, Germany.2Department of Neurobiology and Ethology and Department of Psychology, University of Haifa, and Institute for the Study of Affective Neuroscience, 31905 Haifa, Israel.3Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioural Brain Sciences, Magdeburg, Germany. Electronic address: oliver.stork@ovgu.de.AbstractCircadian fluctuations of fear and anxiety symptoms are observable in persons with post-traumatic stress disorder, generalized anxiety, and panic disorder; however, the underlying neurobiological mechanisms are not sufficiently understood. In the present study, we investigated the putative role of inhibitory neurotransmission in the circadian fluctuation of fear symptoms, using mice with genetic ablation of the γ-amino butyric acid (GABA) synthesizing isoenzyme, glutamic acid decarboxylase GAD65. We observed in these mutant mice an altered expression of conditioned fear with a profound reduction of freezing, and an increase of hyperactivity bouts occurring only when both fear conditioning training and retrieval testing were done at the beginning of their active phase. Mutants further showed an increased arousal response at this time of the day, although, circadian rhythm of home cage activity was unaltered. Hyperactivity and reduced freezing during fear memory retrieval were accompanied by an increased induction of the immediate early gene cFos suggesting hyperactivation of the hippocampus, amygdala, and medial hypothalamus. Our data suggest a role of GAD65-mediated GABA synthesis in the encoding of circadian information to fear memory. GAD65 deficits in a state-dependent manner result in increased neural activation in fear circuits and elicit panic-like flight responses during fear memory retrieval.
Behavioural brain research.Behav Brain Res.2014 Mar 1;260:92-100. doi: 10.1016/j.bbr.2013.11.042. Epub 2013 Dec 1.
Circadian fluctuations of fear and anxiety symptoms are observable in persons with post-traumatic stress disorder, generalized anxiety, and panic disorder; however, the underlying neurobiological mechanisms are not sufficiently understood. In the present study, we investigated the putative role of i
PMID 24300892

Amyloid burden and neural function in people at risk for Alzheimer's Disease.

Johnson SC, Christian BT, Okonkwo OC, Oh JM, Harding S, Xu G, Hillmer AT, Wooten DW, Murali D, Barnhart TE, Hall LT, Racine AM, Klunk WE, Mathis CA, Bendlin BB, Gallagher CL, Carlsson CM, Rowley HA, Hermann BP, Dowling NM, Asthana S, Sager MA.Author information Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial VA Hospital, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address: scj@medicine.wisc.edu.AbstractTo determine the relationship between amyloid burden and neural function in healthy adults at risk for Alzheimer's Disease (AD), we used multimodal imaging with [C-11]Pittsburgh compound B positron emission tomography, [F-18]fluorodeoxyglucose, positron emission tomography , and magnetic resonance imaging, together with cognitive measurement in 201 subjects (mean age, 60.1 years; range, 46-73 years) from the Wisconsin Registry for Alzheimer's Prevention. Using a qualitative rating, 18% of the samples were strongly positive Beta-amyloid (Aβ+), 41% indeterminate (Aβi), and 41% negative (Aβ-). Aβ+ was associated with older age, female sex, and showed trends for maternal family history of AD and APOE4. Relative to the Aβ- group, Aβ+ and Aβi participants had increased glucose metabolism in the bilateral thalamus; Aβ+ participants also had increased metabolism in the bilateral superior temporal gyrus. Aβ+ participants exhibited increased gray matter in the lateral parietal lobe bilaterally relative to the Aβ- group, and no areas of significant atrophy. Cognitive performance and self report cognitive and affective symptoms did not differ between groups. Amyloid burden can be identified in adults at a mean age of 60 years and is accompanied by glucometabolic increases in specific areas, but not atrophy or cognitive loss. This asymptomatic stage may be an opportune window for intervention to prevent progression to symptomatic AD.
Neurobiology of aging.Neurobiol Aging.2014 Mar;35(3):576-84. doi: 10.1016/j.neurobiolaging.2013.09.028. Epub 2013 Oct 23.
To determine the relationship between amyloid burden and neural function in healthy adults at risk for Alzheimer's Disease (AD), we used multimodal imaging with [C-11]Pittsburgh compound B positron emission tomography, [F-18]fluorodeoxyglucose, positron emission tomography , and magnetic resonance i
PMID 24269021

Japanese Journal

健康のリスクファクターとしてのアレキシサイミア(英文誌から)

小嶋雅代
心身医学 55(3), 279, 2015-03-01
NAID 110009917697

脳科学研究からアレキシサイミアと身体疾患の関連経路を探る(英文誌から)

鹿野理子
心身医学 55(2), 172, 2015-02-01
NAID 110009908990

慢性疼痛治療のNBMとEBM(<特集>心身医学的治療のEBMとNBM)

細井昌子
心身医学 55(1), 26-33, 2015-01-01
慢性疼痛の心身医療においては,身体的痛みに合併した患者の独特な生きる痛みにおける苦悩を,患者と治療者の双方向性の対話でnarrativeとして浮き彫りにしていくことが重要である.本稿では,診療でよく耳にする患者のフレーズが,現代医学のどのようなevidenceと関連していると考えられるのか解説した.また,narrativeの中で,現代日本人の抱えやすい苦しみに治療者が気づくために,慢性疼痛医療の中 …
NAID 110009900179

Related Pictures

★リンクテーブル★

リンク元	「失感情症」「affective symptom」「alexithymic」

「失感情症」

Alexithymia
Classification and external resources
Specialty	Psychiatry
	[edit on Wikidata]

　　[★]

英: alexithymia、alexithymic
関: 情緒障害、情動性症状

-alexithymia

-アレキシサイミア

「affective symptom」

　　[★]

情動性症状

関: alexithymia、emotional disturbance

「alexithymic」

　　[★]

失感情症の

関: alexithymia

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[Feldman-2] Feldman-Hall Oriel, Dalgleish Tim, Mobbs Dean. "Alexithymia decreases altruism in real social decisions". Cortex 49: 899–904. doi:10.1016/j.cortex.2012.10.015.

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[Taylor2831-5] Taylor GJ & Taylor HS (1997). Alexithymia. In M. McCallum & W.E. Piper (Eds.) Psychological mindedness: A contemporary understanding. Munich: Lawrence Erlbaum Associates pp. 28–31

[Haviland-6] Haviland MG, Warren WL, Riggs ML (2000). "An observer scale to measure alexithymia". Psychosomatics 41 (5): 385–92. doi:10.1176/appi.psy.41.5.385. PMID 11015624. Retrieved 2007-08-10.

[7] Vorst HCM, Bermond B (2001). "Validity and reliability of the Bermond-Vorst Alexithymia Questionnaire". Personality and Individual Differences 30 (3): 413–434. doi:10.1016/S0191-8869(00)00033-7.

[revneurol.org-8] Paula-Perez I (Mar 2010). "Alexitimia y sindrome de Asperger". Rev Neurol 50 (Suppl 3): S85–90.

[Taylor29-9] Taylor (1997), p. 29

[10] Fukunishi I, Berger D, Wogan J, Kuboki T (1999). "Alexithymic traits as predictors of difficulties with adjustment in an outpatient cohort of expatriates in Tokyo". Psychological reports 85 (1): 67–77. doi:10.2466/PR0.85.5.67-77. PMID 10575975. Retrieved 2007-08-10.

[11] Salminen JK, Saarijärvi S, Aärelä E, Toikka T, Kauhanen J (1999). "Prevalence of alexithymia and its association with sociodemographic variables in the general population of Finland". Journal of psychosomatic research 46 (1): 75–82. doi:10.1016/S0022-3999(98)00053-1. PMID 10088984.

[12] Taylor & Taylor (1997), pp. 77–104

[13] Taylor (1997), p. 38

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[Taylor_1997.2C_p._37-15] Taylor (1997), p. 37

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[18] Nemiah et al. (1970), pp. 432–33

[19] Krystal (1988), p. 246; McDougall (1985), pp. 169–70

[20] Taylor (1997), pp. 29, 246–47

[21] Krystal (1988) pp. 246-247

[22] Nemiah, CJ (1978). "Alexithymia and Psychosomatic Illness". Journal of Continuing Education 39: 25–37.

[23] Sifneos, PE (1967). "Clinical Observations on some patients suffering from a variety of psychosomatic diseases". Acta Medicina Psychosomatica 7: 1–10.

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[26] Jessimer M, Markham R (1997). "Alexithymia: a right hemisphere dysfunction specific to recognition of certain facial expressions?". Brain and cognition 34 (2): 246–58. doi:10.1006/brcg.1997.0900. PMID 9220088.

[27] Lane RD, Ahern GL, Schwartz GE, Kaszniak AW (1997). "Is alexithymia the emotional equivalent of blindsight?". Biol. Psychiatry 42 (9): 834–44. doi:10.1016/S0006-3223(97)00050-4. PMID 9347133.

[28] Tabibnia G, Zaidel E (2005). "Alexithymia, interhemispheric transfer, and right hemispheric specialization: a critical review". Psychotherapy and psychosomatics 74 (2): 81–92. doi:10.1159/000083166. PMID 15741757.

[29] McDougall (1989), pp. 93, 103

[30] McDougall (1989), pp. 93–94

[31] Maclaren K (2006). "Emotional Disorder and the Mind-Body Problem: A Case Study of Alexithymia". Chiasmi International 8: 139–55. doi:10.5840/chiasmi2006819.

[McDougall161-32] McDougall (1985), p. 161

[ReferenceA-33] Jørgensen MM, Zachariae R, Skytthe A, Kyvik K (2007). "Genetic and Environmental Factors in Alexithymia: A Population-Based Study of 8,785 Danish Twin Pairs". Psychotherapy and Psychosomatics 76: 369–375. doi:10.1159/000107565. PMID 17917473.

[34] Williams C, Wood RL (June 2009). "Alexithymia and emotional empathy following traumatic brain injury". J Clin Exp Neuropsychol 32 (3): 1–11. doi:10.1080/13803390902976940. PMID 19548166. Lay summary – Psychology Today (January 3, 2010).

[Vanheule-35] Vanheule S, Desmet M, Meganck R, Bogaerts S (2007). "Alexithymia and interpersonal problems". Journal of clinical psychology 63 (1): 109–17. doi:10.1002/jclp.20324. PMID 17016830.

[36] Blaustein JP, Tuber SB (1998). "Knowing the Unspeakable". Bulletin of the Menninger Clinic 62: 351–365.

[37] Taylor (1997) pp. 26-46

[38] Sifneos PE (1996). "Alexithymia: past and present". The American Journal of Psychiatry 153 (7 Suppl): 137–42. PMID 8659637.

[39] Yelsma P, Marrow S (2003). "An Examination of Couples' Difficulties With Emotional Expressiveness and Their Marital Satisfaction". Journal of Family Communication 3 (1): 41–62. doi:10.1207/S15327698JFC0301_03.

[Colin_Hesse_2008-40] Hesse Colin, Floyd Kory (2008). "Affectionate experience mediates the effects of alexithymia on mental health and interpersonal relationships". Journal of Social and Personal Relationships 25 (5): 793–810. doi:10.1177/0265407508096696.

[41] Manfred F.R. Kets de Vries (2001) "Struggling with the Demon: Perspectives on Individual and Organizational Irrationality"

[Hill-42] Hill E, Berthoz S, Frith U (2004). "Brief report: cognitive processing of own emotions in individuals with autistic spectrum disorder and in their relatives". Journal of Autism and Developmental Disorders 34 (2): 229–235. doi:10.1023/B:JADD.0000022613.41399.14. PMID 15162941.

[FrithAlex-43] Frith U (2004). "Emanuel Miller lecture: confusions and controversies about Asperger syndrome". Journal of child psychology and psychiatry, and allied disciplines 45 (4): 672–86. doi:10.1111/j.1469-7610.2004.00262.x. PMID 15056300. http://onlinelibrary.wiley.com/doi/10.1111/j.1469-7610.2004.00262.x/pdf The study to which Frith refers is the Hill E, Berthoz S, Frith U (2004) referenced before this one.

[Fitzgerald_.26_Bellgrove_2006-44] Fitzgerald M, Bellgrove MA (2006). "The Overlap Between Alexithymia and Asperger's syndrome". Journal of autism and developmental disorders 36 (4): 573–6. doi:10.1007/s10803-006-0096-z. PMC 2092499. PMID 16755385. Retrieved 2007-04-11.

[Hill_.26_Berthoz_2006-45] Hill E, Berthoz S (May 2006). "Response to 'Letter to the Editor: The Overlap Between Alexithymia and Asperger's syndrome', Fitzgerald and Bellgrove, Journal of Autism and Developmental Disorders, 36(4)". Journal of Autism and Developmental Disorders 36 (8): 1143–1145. doi:10.1007/s10803-006-0287-7. PMID 17080269.

[Tani-46] Tani P, Lindberg N, Joukamaa M, et al. (2004). "Asperger syndrome, alexithymia and perception of sleep". Neuropsychobiology 49 (2): 64–70. doi:10.1159/000076412. PMID 14981336.

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[51] The Relationship between Alexithymia and General Symptoms of Patients with Depressive Disorders. Kim JH, Lee SJ, Rim HD, Kim HW, Bae GY, Chang SM. Psychiatry Investig. 2008 Sep; 5(3):179-85. Epub 2008 Sep 30. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796028/

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[53] Taylor GJ, Parker JD, Bagby RM (1990). "A preliminary investigation of alexithymia in men with psychoactive substance dependence". The American Journal of Psychiatry 147 (9): 1228–30. PMID 2386256.

[54] Williams C, Wood RL (March 2010). "Alexithymia and emotional empathy following traumatic brain injury". J Clin Exp Neuropsychol 32 (3): 259–67. doi:10.1080/13803390902976940. PMID 19548166.

[55] Koponen S, Taiminen T, Honkalampi K, et al. (2005). "Alexithymia after traumatic brain injury: its relation to magnetic resonance imaging findings and psychiatric disorders". Psychosom Med 67 (5): 807–12. doi:10.1097/01.psy.0000181278.92249.e5. PMID 16204442.

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[57] Schizotypal, dependent and avoidant disorders are particularly indicated: See Taylor (1997), pp. 162–165

[Li_and_Sinha_2006-58] Li CS, Sinha R (1 March 2006). "Alexithymia and stress-induced brain activation in cocaine-dependent men and women". Journal of psychiatry & neuroscience : JPN 31 (2): 115–21. PMC 1413961. PMID 16575427.

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[Michetti_et_al_2006-61] Michetti PM, Rossi R, Bonanno D, Tiesi A, Simonelli C (2006). "Male sexuality and regulation of emotions: a study on the association between alexithymia and erectile dysfunction (ED)". Int. J. Impot. Res. 18 (2): 170–4. doi:10.1038/sj.ijir.3901386. PMID 16151475. Retrieved 2007-02-02.

[62] Jula A, Salminen JK, Saarijärvi S (1 April 1999). "Alexithymia: a facet of essential hypertension". Hypertension 33 (4): 1057–61. doi:10.1161/01.HYP.33.4.1057. PMID 10205248. Retrieved 2006-12-17.

[63] Verissimo R, Mota-Cardoso R, Taylor G (1998). "Relationships between alexithymia, emotional control, and quality of life in patients with inflammatory bowel disease". Psychotherapy and psychosomatics 67 (2): 75–80. doi:10.1159/000012263. PMID 9556198.

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[Taylor216248-65] Taylor (1997), pp. 216–248

[Taylor190216-66] Taylor (1997), pp. 31

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alexithymia