WordNet

an acute and serious infection of the central nervous system caused by bacterial infection of open wounds; spasms of the jaw and laryngeal muscles may occur during the late stages (同)lockjaw
a sustained muscular contraction resulting from a rapid series of nerve impulses
accumulate (liquids or gases) on the surface

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Stabilization of tetanus toxoid formulation containing aluminium hydroxide adjuvant against freeze-thawing.

Solanki VA, Jain NK, Roy I.SourceDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Punjab 160062, India.
International journal of pharmaceutics.Int J Pharm.2011 Jul 29;414(1-2):140-7. Epub 2011 May 13.
Exposure to subzero temperature leads to loss of vaccine potency. This can happen due to degradation of adjuvant surface and/or inactivation of the antigen. When adsorbed on aluminium hydroxide and subjected to freeze-thawing, tetanus toxoid was desorbed from the gel matrix and the preparation was f
PMID 21605644

Tolerability and antibody response in adolescents and adults revaccinated with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine adsorbed (Tdap) 4-5 years after a previous dose.

Halperin SA, McNeil S, Langley J, Blatter M, Dionne M, Embree J, Johnson R, Latiolais T, Meekison W, Noya F, Senders S, Zickler P, Johnson DR.SourceCanadian Center for Vaccinology, Dalhousie University, Capital Health, and the IWK Health Centre, Halifax, NS, Canada.
Vaccine.Vaccine.2011 Jul 29. [Epub ahead of print]
BACKGROUND: Although decennial adult boosters of tetanus and diphtheria toxoids are recommended in Canada and the United States, a second dose of pertussis vaccine is not currently recommended for adults.METHODS: This open-label, postmarketing, multicenter study evaluated the tolerability and immuno
PMID 21803091

Preliminary Report on Household Contact Studies of the Prevention of Pertussis in Japanese Children by Takeda Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Combined(I. Current Situation of Acellular Pertussis Vaccines)(Clinical Aspects of Acellular Pertussis Vaccines)

MORTIMER Edward A. Jr.
Tokai journal of experimental and clinical medicine 13(Supplement), 29-34, 1988-09-22
… Acellular pertussis vaccines combined with diphtheria and tetanus toxoids and adsorbed onto an aluminum salt (AcPDT) have been used exclusively in Japan for the immunization of children since 1981. … One manufacturer produces AcPDT that contains about 50 percent pertussis toxoid and 50 percent filamentous hemagglutinin (B-type AcPDT). …
NAID 110004700488