WordNet

use recreational drugs (同)do drugs
administer a drug to; "They drugged the kidnapped tourist" (同)dose
a substance that is used as a medicine or narcotic
drug that has the effects of epinephrine (同)adrenergic_drug
relating to epinephrine (its release or action) (同)sympathomimetic
the act of obstructing or deflecting someones movements (同)block

PrepTutorEJDIC

『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/22 10:11:45」(JST)

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An Adrenergic antagonist is a pharmaceutical substance that acts to inhibit the action of catecholamines at the adrenergic receptors. It is thus a type of sympatholytic. Many important and commonly prescribed medications are adrenergic antagonists, including prazosin and propanolol. Like all pharmacological receptor antagonists, adrenergic antagonists only show an effect when the receptor's effector is present.

It has the opposite effect as adrenergic agonists.

More specifically, they can be divided into:

Alpha blockers
Beta blockers

Structure Activity Relationship

If the amine on the Adrenergic agent has a substituent bigger than a tertiary butyl, then the compound becomes an adrenergic antagonist.^[1]

References

^ Medicinal Chemistry of Adrenergics and Cholinergics

External links

Adrenergic antagonists at the US National Library of Medicine Medical Subject Headings (MeSH)

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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English Journal

LOCUS COERULEUS NORADRENERGIC INNERVATION OF THE AMYGDALA FACILITATES ALERTING-INDUCED CONSTRICTION OF THE RAT TAIL ARTERY.

Mohammed M1, Kulasekara K, Ootsuka Y1, Blessing WW2.
American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2016 Apr 13:ajpregu.00058.2016. doi: 10.1152/ajpregu.00058.2016. [Epub ahead of print]
The amygdala, innervated by the noradrenergic locus coeruleus, processes salient environmental events. Alpha-2 adrenoceptor-stimulating drugs (clonidine-like agents) suppress the behavioral and physiological components of the response to salient events. Activation of sympathetic outflow to the cutan
PMID 27101292

The influence of regional anaesthesia and local anesthetics on cardiac repolarization.

Biernawska J1, Kaźmierczak J, Kotfis K, Żukowski M.
Anaesthesiology intensive therapy.Anaesthesiol Intensive Ther.2016 Mar 17. doi: 10.5603/AIT.a2016.0018. [Epub ahead of print]
The normal function of the heart muscle is the result of electro-mechanic and hemodynamic coupling. Modification of the structure and activity of ion channels within the cardiomyocytes may induce cardiac arrhythmias. Electrophysiological mechanisms of arrhythmia, generated by a prolonged period of r
PMID 26986038

Dissociation of β1- and β2-adrenergic receptor subtypes in the retrieval of cocaine-associated memory.

Fitzgerald MK1, Otis JM1, Mueller D2.
Behavioural brain research.Behav Brain Res.2016 Jan 1;296:94-9. doi: 10.1016/j.bbr.2015.08.030. Epub 2015 Aug 28.
Drug seeking is maintained by encounters with drug-associated cues, and disrupting retrieval of these drug-cue associations would reduce the risk of relapse. Retrieval of cocaine-associated memories is dependent on β-adrenergic receptor (β-AR) activation, and blockade of these receptors induces a
PMID 26318933

Japanese Journal

Characteristic interactivity of landiolol, an ultra-short-acting highly selective β1-blocker, with biomimetic membranes: Comparisons with β1-selective esmolol and non-selective propranolol and alprenolol.