WordNet
- a method of tending to or managing the affairs of a some group of people (especially the groups business affairs) (同)disposal
- the act of administering medication (同)giving medication
- the act of meting out justice according to the law (同)judicature
- the persons (or committees or departments etc.) who make up a body for the purpose of administering something; "he claims that the present administration is corrupt"; "the governance of an association is responsible to its members"; "he quickly became rec (同)governance, governing body, establishment, brass, organization, organisation
- the distance between things; "fragile items require separation and cushioning" (同)separation
- the difference in pitch between two notes (同)musical interval
- a set containing all points (or all real numbers) between two given endpoints
PrepTutorEJDIC
- 〈U〉『行政』,統治 / 〈U〉『管理』,経営 / 〈C〉行政機関(省,庁,局など);《the A-》《米》連邦政府(《英》the Government) / 《総称して》(大学・団体などの)管理者側,当局者,教務部 / 〈U〉(裁き・処罰・法冷・儀式などの)執行,施行
- (事と事の)間の時間,『合い間』;(物と物の)間の空間,間隔 / 《英》=intermission / 音程
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. QT短縮症候群 short qt syndrome
- 2. アミノグリコシド（非経口）の用量および投与 dosing and administration of parenteral aminoglycosides
- 3. 非同期性興奮と早期興奮の一般原則 general principles of asynchronous activation and preexcitation
- 4. 人工妊娠中絶に対するミソプロストール単独投与 misoprostol as a single agent for medical termination of pregnancy
- 5. 分子標的薬である血管新生阻害剤の毒性：心血管系への影響 toxicity of molecularly targeted antiangiogenic agents cardiovascular effects
English Journal
- A systematic review of dual targeting in HER2-positive breast cancer.
- Kümler I, Tuxen MK, Nielsen DL.Author information Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730 Herlev, Denmark. Electronic address: Iben.Kumler@regionh.dk.AbstractBACKGROUND: Human epidermal growth factor receptor 2 (HER2) is overexpresed in 15-20% of all breast cancers. Treatment with trastuzumab has led to an improved outcome and prolonged survival of HER2-positive breast cancer patients and today the drug is established as standard of care in both the adjuvant and metastatic settings. However, trastuzumab resistance is common and a major focus in the treatment of HER2-positive breast cancer has been developing therapeutic agents to either potentiate the effect of trastuzumab or to target cells which have become resistant to trastuzumab. The present review addresses efficacy and toxicity of dual targeting in HER2-positive breast cancer.
- Cancer treatment reviews.Cancer Treat Rev.2014 Mar;40(2):259-70. doi: 10.1016/j.ctrv.2013.09.002. Epub 2013 Sep 11.
- BACKGROUND: Human epidermal growth factor receptor 2 (HER2) is overexpresed in 15-20% of all breast cancers. Treatment with trastuzumab has led to an improved outcome and prolonged survival of HER2-positive breast cancer patients and today the drug is established as standard of care in both the adju
- PMID 24080156
- Life-threatening dermatologic adverse events in oncology.
- Rosen AC, Balagula Y, Raisch DW, Garg V, Nardone B, Larsen N, Sorrell J, West DP, Anadkat MJ, Lacouture ME.Author information aDepartment of Medicine, Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York bDepartment of Pharmacy Practice and Administrative Sciences, College of Pharmacy, University of New Mexico cVeterans Affairs Cooperative Studies Program, Albuquerque, New Mexico dDepartment of Dermatology eRobert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois fDepartment of Internal Medicine, Division of Dermatology, Washington University School of Medicine, St Louis, Missouri, USA.AbstractThe incidences of life-threatening toxicities such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are inconsistently reported. The potential association of anticancer agents with SJS or TEN has not been systematically investigated. We searched the literature (Ovid: 1950 to June 2013 and PubMed: 1948 to June 2013) using terms for SJS/TEN and anticancer therapies. Primary case reports, case series, and clinical trials were included. In addition, MedWatch, the Food and Drug Administration Adverse Event Reporting System (FAERS), was searched (1968 to August 2012) for SJS/TEN reports associated with anticancer therapies. Proportional reporting ratios (PRR>2, N>3), empirical Bayes geometric mean (EBGM>2, N>3), and lower 95% confidence interval (EBGM0.05>2) were used as thresholds to constitute a signal of association between SJS/TEN and anticancer drugs. There were 46 SJS and 37 TEN cases associated with 18 and 22 anticancer drugs in the literature, respectively. Among cases in the FAERS, significant signals were associated with SJS for bendamustine and with TEN for bendamustine, busulfan, chlorambucil, fludarabine, lomustine, and procarbazine. Several drugs reported in the published literature to be associated with SJS/TEN were not found to have significant signals in FAERS. Proactive pharmacovigilance to detect and define safety signals serves to aid oncology practitioners in the recognition of possible, yet uncommon, serious, and/or life-threatening skin reactions.
- Anti-cancer drugs.Anticancer Drugs.2014 Feb;25(2):225-34. doi: 10.1097/CAD.0000000000000032.
- The incidences of life-threatening toxicities such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are inconsistently reported. The potential association of anticancer agents with SJS or TEN has not been systematically investigated. We searched the literature (Ovid: 1950 to Ju
- PMID 24108082
- Ethanol effects on multiple fixed-interval, fixed-ratio responding in mice with deletions of the serotonin transporter gene.
- Lamb RJ, Pinkston JW, Daws LC.Author information Departments of aPsychiatry bPhysiology cPharmacology, University of Texas Health Science Center at San Antonio, San Antonio dDepartment of Behavioral Analysis, University of North Texas, Denton, Texas, USA.AbstractSerotonin transporter knockout (KO) mice self-administer less ethanol than either heterozygous or wild-type mice; however, the mechanistic basis for this difference remains unclear. Here we examine the possibility that ethanol more readily decreases responding in KO mice, thereby limiting ethanol self-administration. To examine whether KO mice were more sensitive to the response-decreasing effects of ethanol, we administered ethanol (0.2-3.2 g/kg) to mice responding under a multiple fixed-ratio 30-response, fixed-interval 300-s schedule of milk presentation. Ethanol decreased responding similarly in all three genotypes. Fixed-ratio responding tended to be decreased at lower doses than fixed-interval responding. The decreased level of ethanol self-administration in serotonin transporter KO mice is not explained by an increased sensitivity to the response-decreasing effects of ethanol in KO mice, as sensitivity to the response-decreasing effects of ethanol was similar in the KO, heterozygous, and wild-type mice.
- Behavioural pharmacology.Behav Pharmacol.2014 Feb;25(1):92-5. doi: 10.1097/FBP.0000000000000011.
- Serotonin transporter knockout (KO) mice self-administer less ethanol than either heterozygous or wild-type mice; however, the mechanistic basis for this difference remains unclear. Here we examine the possibility that ethanol more readily decreases responding in KO mice, thereby limiting ethanol se
- PMID 24247279
Japanese Journal
- The fast emergency vehicle pre-emption system improved the outcomes of out-of-hospital cardiac arrest
- Tanaka Yoshio,Yamada Hiroshi,Tamasaku Shuji,Inaba Hideo
- American Journal of Emergency Medicine 31(10), 1466-1471, 2013-10
- … OHCA outcomes were subsequently compared in the subgroup of OHCAs managed by emergency medical technicians without tracheal intubation or epinephrine administration. … Logistic regression analysis revealed that the dispatch of a FAST™-equipped ambulance was an independent factor for 1-Y survival (adjusted odds ratio = 3.077, 95% confidence interval = 1.180-9.350). …
- NAID 120005328800
- ベキ正規分布に基づく階層仮説を用いた生物学的同等性の評価
- 古川 泰伸,後藤 昌司
- 計算機統計学 25(2), 87-104, 2013-06-17
- 後発医薬品や投薬方法の改良による薬剤については,ヒトに対する「生物学的同等性(BioEqui-valence,以下BE)」の評価のみで申請,および承認を受けることが可能である.日本では,厚生省(現厚生労働省,1997)に従い標準製剤と試験製剤の母集団平均の差の信頼区間に基づいてBEが評価されている.他方,上述の評価過程には,諸種の統計的問題が内包され,BEの特徴を理論的かつ方法論的に体系だてて評価 …
- NAID 110009625174
- GABA Affects Novel Object Recognition Memory and Working Memory in Rats
- THANAPREEDAWAT Panicha,KOBAYASHI Hiroki,INUI Naoto,SAKAMOTO Kazuhiro,KIM Mujo,YOTO Ai,YOKOGOSHI Hidehiko
- Journal of Nutritional Science and Vitaminology 59(2), 152-157, 2013
- … The proper retention interval and delay time were also investigated for the NOR test and T-maze test, respectively. … After that, the rats performed the NOR test at a 48 h retention interval and T-maze test at a 900 s delay time to estimate the effects of GABA on learning behavior. … The results showed that the object information in the NOR test was stored as long-term memory and the recognition index (RI) was significantly increased after GABA administration. …
- NAID 130003368162
Related Links
- Recommended intervals between administration of immune globulin preparations and measles- or varicella-containing vaccine. Product / Indication. Dose, including mg immunoglobulin G. (IgG)/kg body weight. Recommended interval before ...
- interval. 切れ間きれまインタバル間隔かんかくインターバル絶え間たえま合間あいま 隔たりへだたり間合いまあい狭間はざま間あいだ隙透きすきげき .... 投与間隔. とうよ かんかく#dosage interval (n) administration interval (n) interdose interval (n) ...
Related Pictures
★リンクテーブル★
| リンク元 | 「投与間隔」「dosage interval」「interdose interval」 |
| 関連記事 | 「administration」「interval」 |
「投与間隔」
「dosage interval」
「interdose interval」
「administration」
- n.
- 関
- administer、administrate、administrative、control、dosing、executive、give、govern、manage、management、medicate、prescription、supervision
- 投薬, 投与= medication
「interval」
- n.