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(biochemistry) purine base found in DNA and RNA; pairs with thymine in DNA and with uracil in RNA (同)A
matter that remains after something has been removed

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1. 母体血中の無細胞核酸を使った非侵襲的出生前検査 noninvasive prenatal testing using cell free nucleic acids in maternal blood
2. 性感染症：思春期特有の問題の概要 sexually transmitted diseases overview of issues specific to adolescents
3. 性器潰瘍患者へのアプローチ approach to the patient with genital ulcers
4. 分子遺伝学の原理 principles of molecular genetics
5. 遺伝学およびゲノミクスのためのツール：ポリメラーゼ連鎖反応 tools for genetics and genomics polymerase chain reaction

Hirano A1, Shi G1, Jones CR2, Lipzen A3,4, Pennacchio LA3,4, Xu Y5, Hallows WC1, McMahon T1, Yamazaki M1, Ptáček LJ1,6, Fu YH1.
eLife.Elife.2016 Aug 16;5. pii: e16695. doi: 10.7554/eLife.16695.
Familial Advanced Sleep Phase (FASP) is a heritable human sleep phenotype characterized by very early sleep and wake times. We identified a missense mutation in the human Cryptochrome 2 (CRY2) gene that co-segregates with FASP in one family. The mutation leads to replacement of an alanine residue at
PMID 27529127

Conversion of adenine to 5-amino-4-pyrimidinylimidazole caused by acetyl capping during solid phase oligonucleotide synthesis.

Rodriguez AA1, Cedillo I2, McPherson AK2.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2016 Aug 1;26(15):3468-71. doi: 10.1016/j.bmcl.2016.06.042. Epub 2016 Jun 18.
The acetyl capping reaction used throughout solid phase oligonucleotide synthesis is meant to minimize n-1 deletionmer impurities by terminating sequences that fail to couple to a phosphoramidite. However, the reaction is also responsible for the formation of a number of impurities. One capping-rela
PMID 27353533

An asparagine residue mediates intramolecular communication in nucleotide-regulated pyrophosphatase.

Anashkin VA1, Salminen A2, Vorobjeva NN3, Lahti R4, Baykov AA5.
The Biochemical journal.Biochem J.2016 Jul 15;473(14):2097-107. doi: 10.1042/BCJ20160293. Epub 2016 May 17.
Many prokaryotic soluble PPases (pyrophosphatases) contain a pair of regulatory adenine nucleotide-binding CBS (cystathionine β-synthase) domains that act as 'internal inhibitors' whose effect is modulated by nucleotide binding. Although such regulatory domains are found in important enzymes and tr
PMID 27208172

Replacement of Tyr50 stacked on the si-face of the isoalloxazine ring of the flavin adenine dinucleotide prosthetic group modulates Bacillus subtilis ferredoxin-NADP+ oxidoreductase activity toward NADPH

Seo Daisuke,Naito Hiroshi,Nishimura Erika,Sakurai Takeshi
Photosynthesis Research 125(1-2), 321-328, 2015-02-20
… To investigate the role of the si-face Tyr50 residue in BsFNR, we replaced Tyr50 with Gly, Ser, and Trp and examined its spectroscopic properties and enzymatic activities in the presence of NADPH and ferredoxin (Fd) from B. …
NAID 120005602822

Single Amino Acid Mutation around Flavin Cofactor Changes pH-Dependence of Basidiomycetes Class I Cellobiose Dehydrogenase Activity

Igarashi Kiyohiko,Samejima Masahiro
Journal of Applied Glycoscience 60(2), 111-116, 2013
… These differences can be explained in terms of the effect of the side chain of the amino acid residue at position 734 on the reactivity of the flavin cofactor. …
NAID 130004481025

Light-Induced Conformational Change and Transient Dissociation Reaction of the BLUF Photoreceptor Synechocystis PixD (Slr1694).

Tanaka Keisuke,Nakasone Yusuke,Okajima Koji,Ikeuchi Masahiko,Tokutomi Satoru,Terazima Masahide
Journal of molecular biology 409(5), 773-785, 2011-06-24
… The light-induced reaction of the BLUF (blue light photoreceptor using flavin adenine dinucleotide) photoreceptor PixD from Synechocystis sp. … These results indicate that the formation of the decamer and the conformational change around the Met residue are important factors that control the regulation of the downstream signal transduction by the PixD photoreceptor. …
NAID 120003203917