WordNet

marked or affected by enlargement or hypertrophy of the extremities or the face; "a protruding acromegalic jaw"
excessive largeness of stature (同)giantism

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1. 下垂体巨人症pituitary gigantism [show details]
…predisposes to the development of gigantism and is consistent with folklore accounts of Irish giants originating in this area . X-linked acrogigantism (XLAG) refers to gigantism due to microduplications in …
2. 思春期に生じる多嚢胞性卵巣症候群の定義、臨床的特徴、および鑑別診断definition clinical features and differential diagnosis of polycystic ovary syndrome in adolescents [show details]
…resistance is also associated with PCOS in the setting of pseudo-Cushing syndrome and pseudo-acromegalic gigantism, disorders which mimic glucocorticoid excess and childhood growth hormone excess clinically…
3. 高身長や異常に急激な成長がみられる小児the child with tall stature and or abnormally rapid growth [show details]
…hormone secretion causes gigantism in growing children and acromegaly after fusion of the epiphyses, usually in adults. Although rare in children, the possibility of gigantism should be considered when …
4. 先端巨大症の原因および臨床症状causes and clinical manifestations of acromegaly [show details]
…Xq26.3 have been associated with excessive GH in children with gigantism and in adults with acromegaly. In a study of 43 patients with gigantism due to GH excess,… compared colon adenoma and cancer rates in 701 acromegalic patients and 1573 control subjects .…
5. カーニー複合carney complex [show details]
…approximately 10 to 15 percent of CNC patients, usually in the third or fourth decade of life . Gigantism resulting from increased GH secretion before puberty is rare. Tumors may be single or multiple and …

English Journal

Hypermethylator Phenotype and Ectopic GIP Receptor in GNAS Mutation-Negative Somatotropinomas.

Hage M, Chaligné R, Viengchareun S, Villa C, Salenave S, Bouligand J, Letouzé E, Tosca L, Rouquette A, Tachdjian G, Parker F, Lombès M, Lacroix A, Gaillard S, Chanson P, Kamenický P.
The Journal of clinical endocrinology and metabolism. 2019 May;104(5)1777-1787.
Besides GNAS gene mutations, the molecular pathogenesis of somatotroph adenomas responsible for gigantism and acromegaly remains elusive. To investigate alternative driver events in somatotroph tumorigenesis, focusing on a subgroup of acromegalic patients with a paradoxical increase in growth hormon
PMID 30376114

Unusual mutation and phenocopy in the family of a young patient with acromegalic gigantism.

Imran SA, Aldahmani KA, Penney L, Croul SE, Clarke DB, Collier DM, Iacovazzo D, Korbonits M.
Endocrinology, diabetes & metabolism case reports. 2018 ;2018().
Early-onset acromegaly causing gigantism is often associated with aryl-hydrocarbon-interacting receptor protein () mutation, especially if there is a positive family history. A15y male presented with tiredness and visual problems. He was 201 cm tall with a span of 217 cm. He had typical facial f
PMID 29472986

Pseudoacromegaly: A Differential Diagnostic Problem for Acromegaly With a Genetic Solution.

Dahlqvist P, Spencer R, Marques P, Dang MN, Glad CAM, Johannsson G, Korbonits M.
Journal of the Endocrine Society. 2017 Aug;1(8)1104-1109.
Acromegaly is usually not a difficult condition to diagnose once the possibility of this disease has been raised. However, a few conditions present with some aspects of acromegaly or gigantism but without growth hormone (GH) excess. Such cases are described as "pseudoacromegaly" or "acromegaloidism"
PMID 29264563

Japanese Journal

Suffocation due to Thoracic Deformity Caused by Acromegaly

Yoshizawa Toshihiko,Iwazaki Masayuki,Jitsuiki Kei,Ishikawa Kouhei,Ohsaka Hiromichi,Yanagawa Youichi
Internal Medicine 56(8), 949-951, 2017
… <p>A 61-year-old man with gigantism and acromegaly choked and fell into a coma. … Physicians should focus on clearing the tracheal airway using computed tomography to elucidate the anatomical relationship between the trachea and surrounding structures in acromegalic patients suffering from dyspnea. …
NAID 130006857612

Pyodermia Chronica Glutealis Complicated by Acromegalic Gigantism

NISHIJIMA Setsuko,KASAHARA Mika,SUZUKI Kenji,KONDOH Masako,TSUBURA Airo
Journal of dermatology 25(4), 242-245, 1998-04-01
NAID 10016267582

Acromegalic Gigantism with Low Serum Level of Growth Hormone and Elevated Serum Insulin-Like Growth Factor-I

MIYAZAKI Reiko,YOSHIDA Toshihide,SAKANE Naoki,YASUDA Tomoko,UMEKAWA Tsunekazu,KONDO Motoharu,SHIMATSU Akira,HIZUKA Naomi,SANO Toshiaki
Internal medicine 34(3), 183-187, 1995-03-01
… In a case of acromegalic gigantism with hyperprolactinemia is reported, the basal serum growth hormone (GH) levels ranged from 1.2 to 1.9 ng/ml. … In this case, non-pulsatile GH secretion and enhanced tissue sensitivity to GH may induce hypersecretion of IGF-I and cause clinical acromegalic gigantism.<br>(Internal Medicine 34:183-187, 1995) …
NAID 10008450364