In the absence of universally available antiretroviral (ARV) drugs or a vaccine against HIV-1, microbicides may offer the most immediate hope for controlling the AIDS pandemic. The most advanced and clinically effective microbicides are based on ARV agents that interfere with the earliest stages of
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 Nov 11;111(45):E4878-86. doi: 10.1073/pnas.1413582111. Epub 2014 Oct 27.
Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induced DNA damage; the alkyladenine DNA glycosylase (Aag/Mpg
Mycobacterium smegmatis DinB2 misincorporates deoxyribonucleotides and ribonucleotides during templated synthesis and lesion bypass.
Ordonez H1, Shuman S2.
Nucleic acids research.Nucleic Acids Res.2014 Nov 10;42(20):12722-34. doi: 10.1093/nar/gku1027. Epub 2014 Oct 28.
Mycobacterium smegmatis DinB2 is the founder of a clade of Y-family DNA polymerase that is naturally adept at utilizing rNTPs or dNTPs as substrates. Here we investigate the fidelity and lesion bypass capacity of DinB2. We report that DinB2 is an unfaithful DNA and RNA polymerase with a distinctive
… MAMOG was identified as to leadingto "Eco" from environmental and economic perspectives using abasic statistical analysis method.Furthermore, two component factors were investigated -B22. …
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Abasic definition, inability to walk due to a limitation or absence of muscular coordination. See more. Thesaurus Translator Reference Word of the Day Blog Slideshows Apps by Dictionary My Account Log Out Log In Dictionary ...