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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/18 09:10:14」(JST)

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Rocuronium (Zemuron, Esmeron) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Development [edit]

It was designed to be a weaker antagonist at the neuromuscular junction than pancuronium; hence its monoquaternary structure and its having an allyl group and a pyrrolidine group attached to the D ring quaternary nitrogen atom. Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action.^[1] It is marketed under the trade name of Zemuron in the United States and Esmeron in most other countries.

There is considered to be a risk of allergic reaction to the drug in some patients (particularly those with asthma), but a similar incidence of allergic reactions has been observed by using other members of the same drug class (non-depolarizing neuromuscular blocking drugs).^[2]

The γ-cyclodextrin derivative sugammadex (trade name Bridion) has been recently introduced as a novel agent to reverse the action of rocuronium. ^[3]

On July 27, 2012, the State of Virginia replaced pancuronium bromide, one of the three drugs used in execution by lethal injection, with this drug.

References [edit]

^ Hunter JM (April 1996). "Rocuronium: the newest aminosteroid neuromuscular blocking drug". British Journal of Anaesthesia 76 (4): 481–3. PMID 8652315.
^ Burburan SM, Xisto DG, Rocco PR (June 2007). "Anaesthetic management in asthma". Minerva Anestesiologica 73 (6): 357–65. PMID 17115010.
^ Naguib M (March 2007). "Sugammadex: another milestone in clinical neuromuscular pharmacology". Anesthesia and Analgesia 104 (3): 575–81. doi:10.1213/01.ane.0000244594.63318.fc. PMID 17312211.

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UpToDate Contents

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1. General anesthesia: Maintenance and emergence
2. 重症筋無力症患者に対する麻酔 anesthesia for the patient with myasthenia gravis
3. Neuromuscular blocking agents (NMBA) for rapid sequence intubation in adults outside the operating room
4. 重症患者における神経筋遮断剤の使用 use of neuromuscular blocking medications in critically ill patients
5. 小児に対する急速挿管法（RSI） rapid sequence intubation rsi in children

English Journal

Anaphylaxis Incidence with Rocuronium, Succinylcholine, and Atracurium: How Risk Communication Can Influence Behavior.

Dewachter P1, Mouton-Faivre C.
Anesthesiology.Anesthesiology.2015 Sep;123(3):735-6. doi: 10.1097/ALN.0000000000000775.
PMID 26284871

Reversal of neuromuscular block in companion animals.

Jones RS1, Auer U2, Mosing M3.
Veterinary anaesthesia and analgesia.Vet Anaesth Analg.2015 Sep;42(5):455-71. doi: 10.1111/vaa.12272. Epub 2015 Jun 8.
OBJECTIVE: To review the evidence regarding the reversal of neuromuscular block (NMB) in companion animals with emphasis on the development and use of newer agents.DATABASE USED: Data sources include scientific reviews and original research publications in both human and veterinary literature using
PMID 26058553

Rocuronium: automatic infusion versus manual administration with TOF monitorisation.

Ozturk Arikan FG1, Turan G, Ozgultekin A, Sivrikaya Z, Cosar BC, Onder DN.
Journal of clinical monitoring and computing.J Clin Monit Comput.2015 Aug 18. [Epub ahead of print]
TOF (train-of-four) monitoring provides objective data in application of neuromuscular blocking agent. Thus, applicator-based differences are eliminated and optimum muscle relaxation is maintained during operation. In the present study, we aimed to compare the effects of target-controlled infusion s
PMID 26278704

Related Pictures

Zemuron Rocuronium Bromide Injection — AuroMedics Pharma LLC Sodium Bicarbonate Side Effects And Contraindications | Autos Post Rocuronium Bromide Inj multiple dose glass fliptop vial | Alternate Site Sedation Rocuronium Bromide Injection 10mg/ml , 10 x 5 ml X-Gen : 03982242002 ZEMURON Medical Labels - Free Shipping ZEMURON Expiration Date Medical Labels - Free Shipping rocuronium intravenous : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

★リンクテーブル★

リンク元

「ロクロニウム」

Rocuronium bromide
Systematic (IUPAC) name
	1-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetoxy-3-hydroxy-10,13-dimethyl-2-morpholinohexadecahydro-1H-cyclopenta[a]phenanthren-16-yl)-1-allylpyrrolidinium bromide
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	?
Legal status	POM (UK)
Routes	Intravenous
Pharmacokinetic data
Bioavailability	NA
Protein binding	~30%
Metabolism	some de-acetylation
Half-life	66–80 minutes
Excretion	Unchanged, in bile and urine
Identifiers
CAS number	119302-91-9
ATC code	M03AC09
PubChem	CID 441290
IUPHAR ligand	4003
DrugBank	DB00728
UNII	I65MW4OFHZ
ChEMBL	CHEMBL1201244
Synonyms	[3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Chemical data
Formula	C32H53N2O4+
Mol. mass	529.774 g/mol
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　　[★]

英: rocuronium
化: 臭化ロクロニウム、rocuronium bromide Rb
商: エスラックス、Zemuron
関: 筋弛緩薬、非脱分極性筋弛緩薬

筋弛緩薬;四級アンモニウム;神経筋遮断薬;競合性
拮抗薬：スガマデクス

[pmid8652315-1] Hunter JM (April 1996). "Rocuronium: the newest aminosteroid neuromuscular blocking drug". British Journal of Anaesthesia 76 (4): 481–3. PMID 8652315.

[pmid17115010-2] Burburan SM, Xisto DG, Rocco PR (June 2007). "Anaesthetic management in asthma". Minerva Anestesiologica 73 (6): 357–65. PMID 17115010.

[pmid17312211-3] Naguib M (March 2007). "Sugammadex: another milestone in clinical neuromuscular pharmacology". Anesthesia and Analgesia 104 (3): 575–81. doi:10.1213/01.ane.0000244594.63318.fc. PMID 17312211.

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案内

案内

Zemuron