WordNet

a poisonous substance produced during the metabolism and growth of certain microorganisms and some higher plant and animal species

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1. 美容適応としてのボツリヌス毒素投与の概要 overview of botulinum toxin for cosmetic indications
2. 小児における志賀毒素産生性大腸菌（STEC）溶血性尿毒症症候群（HUS）の治療および予後 treatment and prognosis of shiga toxin producing escherichia coli stec hemolytic uremic syndrome hus in children
3. 美容適応としてのボツリヌス毒素：特定部位治療 botulinum toxin for cosmetic indications treatment of specific sites
4. 非神経性の下部尿路症状の治療におけるボツリヌス毒素の使用 use of botulinum toxin for treatment of non neurogenic lower urinary tract conditions
5. アカラシアに対する空気圧式拡張術とボツリヌス毒素注入 pneumatic dilation and botulinum toxin injection for achalasia

Shiga toxin of enterohaemorrhagic Escherichia coli directly injures developing human erythrocytes.

Betz J1, Dorn I2, Kouzel IU1,3, Bauwens A1, Meisen I1,3, Kemper B4,5, Bielaszewska M1, Mormann M1, Weymann L1, Sibrowski W6, Karch H1, Schlenke P6,7, Müthing J8,9.
Cellular microbiology.Cell Microbiol.2016 Oct;18(10):1339-48. doi: 10.1111/cmi.12592. Epub 2016 Apr 29.
Haemolytic anaemia is one of the characteristics of life-threatening extraintestinal complications in humans during infection with enterohaemorrhagic Escherichia coli (EHEC). Shiga toxins (Stxs) of EHEC preferentially damage microvascular endothelial cells of the kidney and the brain, whereby occlud
PMID 26990252

Retrograde Transport from Early Endosomes to the trans-Golgi Network Enables Membrane Wrapping and Egress of Vaccinia Virus Virions.

Sivan G1, Weisberg AS1, Americo JL1, Moss B2.
Journal of virology.J Virol.2016 Sep 12;90(19):8891-905. doi: 10.1128/JVI.01114-16. Print 2016 Oct 1.
The anterograde pathway, from the endoplasmic reticulum through the trans-Golgi network to the cell surface, is utilized by trans-membrane and secretory proteins. The retrograde pathway, which directs traffic in the opposite direction, is used following endocytosis of exogenous molecules and recycli
PMID 27466413

Conserved arginines at the P-protein stalk binding site and at the active site are critical for ribosome interactions of Shiga toxins, but do not contribute to differences in the affinity of the A1 subunits for the ribosome.

Basu D1, Kahn JN1, Li XP1, Tumer NE2.
Infection and immunity.Infect Immun.2016 Sep 6. pii: IAI.00630-16. [Epub ahead of print]
The A1 subunit of Shiga toxin 1 (Stx1A1) and Shiga toxin 2 (Stx2A1) interact with the conserved C-termini of ribosomal stalk P-proteins to remove a specific adenine from the sarcin/ricin loop. We previously showed that Stx2A1 has higher affinity for the ribosome and higher catalytic activity than St
PMID 27600507

泊賢太郎,嘉悦明彦,上野裕之,蕪木康郎,菊地孝司,小堀すみえ,宮崎元伸
感染症学雑誌 90(6), 792-797, 2016
… 血性大腸菌（enterohemorrhagic <i>Escherichia coli</i>；EHEC）O157感染事例が発生した．それぞれ異なる医療機関から腸管出血性大腸菌感染症発生届が提出され，ベロ毒素（Vero toxin；VT，または志賀毒素Shiga toxin；Stx）について，一方にはStx1産生，もう一方にはStx1およびStx2産生と記載されていた．通常別事例とされる内容であったが，保健所による聞き取り調査により，2事例に共 …
NAID 130006708492

濵崎俊輔,村田祐二郎,坂東道哉 [他],森正樹,佐藤裕二
日本臨床外科学会雑誌 76(4), 817-821, 2015
… 血症を疑い緊急手術を施行した．腸管の広範な浮腫と褐色変化を認め，終末回腸から下行結腸を切除し回腸人工肛門とS状結腸粘液瘻を造設した．第4病日，内視鏡時の粘膜生検培養より腸管出血性大腸菌O-157とVero毒素が検出された．術後は良好に経過し第60病日に退院となった．<BR>本疾患は保存的治療が基本であり外科的治療を必要とした報告は少ない．汎発性腹膜炎を呈する本疾患の場合，治療の機会を逸するこ …
NAID 130005106559