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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/24 23:51:12」(JST)

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Cadherin 5, type 2 or VE-cadherin (vascular endothelial) also known as CD144 (Cluster of Differentiation 144), is a type of cadherin. It is encoded by the human gene CDH5.^[1]

Function

VE-cadherin is a classical cadherin from the cadherin superfamily and the gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.^[2]

Integrity of intercellular junctions is a major determinant of permeability of the endothelium, and the VE-cadherin-based adherens junction is thought to be particularly important. VE-cadherin is known to be required for maintaining a restrictive endothelial barrier – early studies using blocking antibodies to VE-cadherin increased monolayer permeability in cultured cells^[3] and resulted in interstitial edema and hemorrhage in vivo.^[4]

VE-cadherin is indispensable for proper vascular development – there have been two transgenic mouse models of VE-cadherin deficiency, both embryonic lethal due to vascular defects.^[5]^[6] Further studies using one of these models revealed that although vasculogenesis occurred, nascent vessels collapsed or disassembled in the absence of VE-cadherin.^[7] Therefore it was concluded that VE-cadherin serves the purpose of maintaining newly formed vessels.

Interactions

VE-cadherin has been shown to interact with:

Beta-catenin^[8]^[9]
Plakoglobin^[8]^[9]
PTPRB^[10]
Catenin (cadherin-associated protein), alpha 1^[8]^[9]
CTNND1^[11]^[12]
PTPmu (PTPRM)^[13]
PTPrho (PTPRT)^[14]

References

^ Suzuki S, Sano K, Tanihara H (April 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
^ "Entrez Gene: CDH5 cadherin 5, type 2, VE-cadherin (vascular epithelium)".
^ Corada M, Liao F, Lindgren M, Lampugnani MG, Breviario F, Frank R et al. (March 2001). "Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability". Blood 97 (6): 1679–84. doi:10.1182/blood.V97.6.1679. PMID 11238107.
^ Corada M, Zanetta L, Orsenigo F, Breviario F, Lampugnani MG, Bernasconi S et al. (August 2002). "A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability". Blood 100 (3): 905–11. doi:10.1182/blood.V100.3.905. PMID 12130501.
^ Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F et al. (July 1999). "Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis". Cell 98 (2): 147–57. doi:10.1016/S0092-8674(00)81010-7. PMID 10428027.
^ Gory-Fauré S, Prandini MH, Pointu H, Roullot V, Pignot-Paintrand I, Vernet M et al. (May 1999). "Role of vascular endothelial-cadherin in vascular morphogenesis". Development 126 (10): 2093–102. PMID 10207135. Vancouver style error (help)
^ Crosby CV, Fleming PA, Argraves WS, Corada M, Zanetta L, Dejana E et al. (April 2005). "VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly". Blood 105 (7): 2771–6. doi:10.1182/blood-2004-06-2244. PMID 15604224.
^ ^a ^b ^c Lewalle JM, Bajou K, Desreux J, Mareel M, Dejana E, Noël A et al. (Dec 1997). "Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro". Exp. Cell Res. 237 (2): 347–56. doi:10.1006/excr.1997.3799. PMID 9434630. Vancouver style error (help)
^ ^a ^b ^c Shasby DM, Ries DR, Shasby SS, Winter MC (Jun 2002). "Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin". Am. J. Physiol. Lung Cell Mol. Physiol. 282 (6): L1330–8. doi:10.1152/ajplung.00329.2001 (inactive 2015-01-01). PMID 12003790.
^ Nawroth R, Poell G, Ranft A, Kloep S, Samulowitz U, Fachinger G et al. (Sep 2002). "VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts". EMBO J. 21 (18): 4885–95. doi:10.1093/emboj/cdf497. PMC 126293. PMID 12234928.
^ Ferber A, Yaen C, Sarmiento E, Martinez J (Mar 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44. doi:10.1006/excr.2001.5436. PMID 11855855.
^ Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (Sep 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell. Sci. 110 (17): 2065–77. PMID 9378757.
^ Sui XF, Kiser TD, Hyun SW, Angelini DJ, Del Vecchio RL, Young BA et al. (2005). "Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia.". Am J Pathol 166 (4): 1247–58. doi:10.1016/s0002-9440(10)62343-7. PMC 1602370. PMID 15793303.
^ Besco JA, Hooft van Huijsduijnen R, Frostholm A, Rotter A (2006). "Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT).". Brain Res 1116 (1): 50–7. doi:10.1016/j.brainres.2006.07.122. PMID 16973135.

External links

VE-cadherin protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
CDH5 human gene location in the UCSC Genome Browser.
CDH5 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Velazquez VM1, Uebelhoer LS, Thapa M, Ibegbu C, Courtney C, Bosinger SE, Magliocca JF, Adams AB, Kirk AD, Knechtle SJ, Kalman D, Suthar M, Grakoui A.
Hepatology (Baltimore, Md.).Hepatology.2014 Oct 21. doi: 10.1002/hep.27575. [Epub ahead of print]
Chronic liver disease is characterized by the liver enrichment of myeloid DCs. To assess the role of disease on myelopoiesis, we utilized a systems biology approach to study development in liver-resident cells expressing stem cell marker CD34. In patients with end-stage liver disease, liver CD34+ ce
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An RGD motif present in cadherin 17 induces integrin activation and tumor growth.

Bartolome R1, Pelaez-Garcia A1, Gomez I2, Torrres S1, Fernandez-Acenero MJ3, Escudero-Paniagua B1, Imbaud JI2, Casal JI4.
The Journal of biological chemistry.J Biol Chem.2014 Oct 21. pii: jbc.M114.600502. [Epub ahead of print]
Little is known about the mechanism of integrin activation by cadherin 17 (CDH17). Here, we observed the presence of a tripeptide motif RGD in the domain 6 of the human CDH17 sequence and other cadherins such as cadherin 5 and cadherin 6. The use of CDH17 RAD mutants demonstrated a considerable decr
PMID 25336636

SHP2 and FAK Protein Interactions Regulate Pulmonary Endothelium Barrier Function.

Chichger H1, Braza J, Duong H, Harrington EO.
American journal of respiratory cell and molecular biology.Am J Respir Cell Mol Biol.2014 Oct 15. [Epub ahead of print]
Enhanced protein tyrosine phosphorylation (PTP) is associated with changes in vascular permeability through formation and dissolution of adherens junctions and regulation of stress fiber formation. Inhibition of the PTP, SHP2, increases tyrosine phosphorylation of VE-cadherin and β-catenin, resulti
PMID 25317600

Japanese Journal

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

Yoshioka Kazuaki,Yoshida Kotaro,Cui Hong,Wakayama Tomohiko,Takuwa Noriko,Okamoto Yasuo,Du Wa,Qi Xun,Asanuma Ken,Sugihara Kazushi,Aki Sho,Miyazawa Hidekazu,Biswas Kuntal,Nagakura Chisa,Ueno Masaya,Iseki Shoichi,Schwartz Robert J.,Okamoto Hiroshi,Sasaki Takehiko,Matsui Osamu,Asano Masahide,Adams Ralf H.,Takakura Nobuyuki,Takuwa Yoh
Nature Medicine 18(10), 1560-1569, 2012-10
… PI3K-C2α knockdown in endothelial cells resulted in a decrease in the number of PI3-phosphate-enriched endosomes, impaired endosomal trafficking, defective delivery of VE-cadherin to endothelial cell junctions and defective junction assembly. …
NAID 120004966617

VE-Cadherin^<low> α-Smooth Muscle Actin^+ Component of Vascular Progenitor Cells Correlates With the Coronary Artery Gensini Score

WANG Chao-Hung,HSIEH I-Chang,CHEN Shih-Jen,WANG Jong-Shyan,CHERNG Wen-Jin,CHEN Chun-Chi,LAM Iii-Jan,LIN Shing-Jong
Circulation journal : official journal of the Japanese Circulation Society 76(2), 477-484, 2012-01-25
… A subpopulation of VPCs expressed both endothelial (VE-cadherin [VE-Cad]) and smooth-muscle phenotypes (α-smooth muscle actin [α-SMA]). … Correlations of the VE-Cadlowα-SMA+ VPC level and adhesion molecule expression by VPCs with the Gensini score were investigated. …
NAID 10030036076

SAM-based cell transfer to photopatterned hydrogels for microengineering vascular-like structures

Sadr Nasser,Zhu Mojun,Osaki Tatsuya,Kakegawa Takahiro,Yang Yunzhi,Moretti Matteo,Fukuda Junji,Khademhosseini Ali,福田淳二
Biomaterials 32(30), 7479-7490, 2011-10
… The latter, prompted by additional potential application, preserved cell morphology and maintained high transfer efficiency of VE-cadherin positive monolayers over longer culture periods. …
NAID 80021956594

Related Pictures

★リンクテーブル★

リンク元	「VEカドヘリン」「VE-カドヘリン」
関連記事	「V」

「VEカドヘリン」

Cadherin 5, type 2 (vascular endothelium)
Identifiers
Symbols	CDH5 ; 7B4; CD144
External IDs	OMIM: 601120 MGI: 105057 HomoloGene: 1359 GeneCards: CDH5 Gene
Gene ontology
Molecular function	• receptor binding; • calcium ion binding; • protein binding; • beta-catenin binding; • protein phosphatase binding; • ion channel binding;
Cellular component	• plasma membrane; • cell-cell junction; • tight junction; • membrane; • integral component of membrane; • cell junction;
Biological process	• blood vessel maturation; • homophilic cell adhesion; • negative regulation of cell proliferation; • cell junction assembly; • adherens junction organization; • cell-cell junction organization; • regulation of establishment of cell polarity;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: VE-cadherin
関: VE-カドヘリン

「VE-カドヘリン」

　　[★]

英: VE-cadherin
関: VEカドヘリン

「V」

　　[★]

[pmid2059658-1] Suzuki S, Sano K, Tanihara H (April 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.

[entrez-2] "Entrez Gene: CDH5 cadherin 5, type 2, VE-cadherin (vascular epithelium)".

[pmid11238107-3] Corada M, Liao F, Lindgren M, Lampugnani MG, Breviario F, Frank R et al. (March 2001). "Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability". Blood 97 (6): 1679–84. doi:10.1182/blood.V97.6.1679. PMID 11238107.

[pmid12130501-4] Corada M, Zanetta L, Orsenigo F, Breviario F, Lampugnani MG, Bernasconi S et al. (August 2002). "A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability". Blood 100 (3): 905–11. doi:10.1182/blood.V100.3.905. PMID 12130501.

[pmid10428027-5] Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F et al. (July 1999). "Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis". Cell 98 (2): 147–57. doi:10.1016/S0092-8674(00)81010-7. PMID 10428027.

[pmid10207135-6] Gory-Fauré S, Prandini MH, Pointu H, Roullot V, Pignot-Paintrand I, Vernet M et al. (May 1999). "Role of vascular endothelial-cadherin in vascular morphogenesis". Development 126 (10): 2093–102. PMID 10207135. Vancouver style error (help)

[pmid15604224-7] Crosby CV, Fleming PA, Argraves WS, Corada M, Zanetta L, Dejana E et al. (April 2005). "VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly". Blood 105 (7): 2771–6. doi:10.1182/blood-2004-06-2244. PMID 15604224.

[pmid9434630-8] Lewalle JM, Bajou K, Desreux J, Mareel M, Dejana E, Noël A et al. (Dec 1997). "Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro". Exp. Cell Res. 237 (2): 347–56. doi:10.1006/excr.1997.3799. PMID 9434630. Vancouver style error (help)

[pmid12003790-9] Shasby DM, Ries DR, Shasby SS, Winter MC (Jun 2002). "Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin". Am. J. Physiol. Lung Cell Mol. Physiol. 282 (6): L1330–8. doi:10.1152/ajplung.00329.2001 (inactive 2015-01-01). PMID 12003790.

[pmid12234928-10] Nawroth R, Poell G, Ranft A, Kloep S, Samulowitz U, Fachinger G et al. (Sep 2002). "VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts". EMBO J. 21 (18): 4885–95. doi:10.1093/emboj/cdf497. PMC 126293. PMID 12234928.

[pmid11855855-11] Ferber A, Yaen C, Sarmiento E, Martinez J (Mar 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44. doi:10.1006/excr.2001.5436. PMID 11855855.

[pmid9378757-12] Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (Sep 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell. Sci. 110 (17): 2065–77. PMID 9378757.

[pmid15793303-13] Sui XF, Kiser TD, Hyun SW, Angelini DJ, Del Vecchio RL, Young BA et al. (2005). "Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia.". Am J Pathol 166 (4): 1247–58. doi:10.1016/s0002-9440(10)62343-7. PMC 1602370. PMID 15793303.

[pmid16973135-14] Besco JA, Hooft van Huijsduijnen R, Frostholm A, Rotter A (2006). "Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT).". Brain Res 1116 (1): 50–7. doi:10.1016/j.brainres.2006.07.122. PMID 16973135.

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VE-cadherin