関: See Vitamin D response element

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/29 16:31:30」(JST)

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Vitamin D response element (VDRE) is a DNA sequence that is found in the promoter region of vitamin D regulated genes. The receptor for 1,25(OH)2D (VDR) binds to and regulates the expression of some genes.

These response elements typically consist of two conserved hexameric half-sites separated by a three nucleotide spacer, referred to as a DR3 type element.^[1] Although it is known that the sequence of a VDRE can have a strong influence on the degree of protein binding, particularly at the fifth position in the half-site,^[2] previous studies have focused on synthetic variations of response elements and not naturally occurring sequences.^[3]

The VDR is widely distributed in tissues, and is not restricted to those tissues considered the classic targets of vitamin D. The VDR upon binding to 1,25(OH)2D heterodimerizes with other nuclear hormone receptors, in particular the family of retinoid X receptors. This complex then binds to special DNA sequences called vitamin D response elements (VDRE) in the promoters of genes which it regulates. A variety of additional proteins called coactivators complex with the activated VDR/RXR heterodimers either to form a bridge from the VDR/RXR complex binding to the VDRE to the proteins responsible for transcription such as RNA polymerase II binding to the transcription start site or to help unravel the chromatin at the site of the gene via recruitment of histone acetyl transferases (HAT), allowing transcription to proceed.^[3]

References

^ Roff A, Wilson RT' ' (March 2009). "A Novel SNP in a Vitamin D Response Element of the CYP24A1 Promoter Reduces Protein Binding, Transactivation, and Gene Expression". J Steroid Biochem Mol Biol 112 (1-3): 47–54. doi:10.1016/j.jsbmb.2008.08.009. PMC 2749287. PMID 18824104.
^ Jin CH, Pike JW' ' (1996). "Human vitamin D receptor-dependent transactivation in Saccharomyces cerevisiae requires retinoid X receptor.". Mol Endocrinol. 65 (7): 1255–1266. PMID 8825559.
^ ^a ^b Umesono K, Murakami KK, Thompson CC, Evans RM' ' (28 June 1991). "HDirect repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors.". Cell 10 (2): 196–205. doi:10.1016/0092-8674(91)90020-Y. PMID 1648450.

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English Journal

Restoration of the anti-proliferative and anti-migratory effects of 1,25-dihydroxyvitamin D by silibinin in vitamin D-resistant colon cancer cells.

Bhatia V1, Falzon M2.
Cancer letters.Cancer Lett.2015 Jul 1;362(2):199-207. doi: 10.1016/j.canlet.2015.03.042. Epub 2015 Apr 3.
Colorectal carcinoma (CRC) is the third most common cancer in developed countries. A large fraction of cases are linked to chronic intestinal inflammation, with concomitant increased TNF-α release and elevated Snail1/Snail2 levels. These transcription factors in turn suppress vitamin D receptor (VD
PMID 25846868

Resveratrol potentiates vitamin D and nuclear receptor signaling.

Dampf Stone A1, Batie SF, Sabir MS, Jacobs ET, Lee JH, Whitfield GK, Haussler MR, Jurutka PW.
Journal of cellular biochemistry.J Cell Biochem.2015 Jun;116(6):1130-43. doi: 10.1002/jcb.25070.
The 1,25-dihydroxyvitamin D3 (1,25D) hormone is derived from vitamin D generated in skin or obtained from the diet, and binds to and activates the vitamin D receptor (VDR) in target tissues including kidney, colon/small intestine, and bone/muscle. We tested resveratrol for its ability to modulate VD
PMID 25536521

Vitamin D and alternative splicing of RNA.

Zhou R1, Chun RF2, Lisse TS3, Garcia AJ2, Xu J4, Adams JS2, Hewison M5.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2015 Apr;148:310-7. doi: 10.1016/j.jsbmb.2014.09.025. Epub 2014 Oct 16.
The active form of vitamin D (1α,25-dihydroxyvitamin D, 1,25(OH)2D) exerts its genomic effects via binding to a nuclear high-affinity vitamin D receptor (VDR). Recent deep sequencing analysis of VDR binding locations across the complete genome has significantly expanded our understanding of the act
PMID 25447737

Japanese Journal

3.ビタミンDレセプターによる転写抑制機能(脂溶性ビタミン総合研究委員会第306回会議研究発表要旨)

加藤茂明
ビタミン 78(10), 526-527, 2004-10-25
… (1997)Science277, 827), この遺伝子プロモーター上に負のVDRE(1α-nVDRE)配列が存在し(Murayama A et al(1998)BBRC249, 11), 更にこの配列に結合する特異因子VDIRの同定にも成功した(Murayama A et al. … <山本浩範氏>Positive VDREへのVDR/RXR/1, 25D3の結合はHAT複合体をリクルートしますが, negativeVDRE/VDIRへのVDR/RXR/1, 25D3の結合は, なぜHDAC複合体をリクルートできるのでしょうか. …
NAID 110002880339

Prostate cancer cell type-specific regulation of the human PTHrP gene via a negative VDRE

TOVAR SEPULVEDA V. A.
Mol. Cell Endocrinol. 204, 51-64, 2003
NAID 30005159217

ヒト RANK ligand 遺伝子の5'側上流領域の解析

梶本和義,北澤理子,北澤荘平
神戸大学医学部紀要 62(3・4), 143-150, 2002-03-29
… ゲルシフトアッセイでは3箇所の vitamin D_3 結合配列 (VDRE) 類似配列のうち最上流 (-1584/-1570) のAGGTCAAAGACTACAがVDR, RXRaヘテロダイマーと in vitro での結合性を示した。 …
NAID 110004653156

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