カルシトリオール受容体、カルシトリオールレセプター、ビタミンD受容体、ビタミンDレセプター

関: VDR、vitamin D receptor、vitamin D3 receptor

WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/30 20:33:44」(JST)

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[Wiki en表示]

The calcitriol receptor, also known as the vitamin D receptor (VDR) and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors.^[1] Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or transrepression of specific geneproducts. The VDR not only regulates transcriptional responses but also involved in microRNA-directed post transcriptional mechanisms.^[2] In humans, the vitamin D receptor is encoded by the VDR gene.^[3]

Glucocorticoids are known to decrease expression of VDR, which is expressed in most tissues of the body and regulate intestinal transport of calcium, Iron and other minerals.^[4]

Function

This gene encodes the nuclear hormone receptor for vitamin D₃. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows similarity of sequence to the steroid and thyroid hormone receptors.^[5]

Downstream targets of this nuclear hormone receptor are involved principally in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.^[6]

Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.^[7]

The vitamin D receptor plays an important role in regulating the hair cycle. Loss of VDR is associated with hair loss in experimental animals.^[8] Experimental studies have shown that the unliganded VDR interacts with regulatory regions in cWnt (wnt signaling pathway) and sonic hedgehog target genes and is required for the induction of these pathways during the postnatal hair cycle.^[9] These studies have revealed novel actions of the unliganded VDR in regulating the post-morphogenic hair cycle.

Interactions

Calcitriol receptor has been shown to interact with

BAG1,^[10]
BAZ1B,^[11]
CAV3,^[12]
MED1,^[11]^[13]
MED12,^[11]^[11]^[13]
NCOR1,^[14]
NCOR2,^[14]^[15]
NCOA2,^[11]^[16]^[17]^[18]
RXRA,^[17]^[19]
RUNX1,^[15]
RUNX1T1,^[15]
SNW1,^[17]^[19]
STAT1,^[20] and
ZBTB16.^[15]^[21]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Vitamin D Synthesis Pathway edit]]

File:VitaminDSynthesis WP1531.png

Vitamin D Synthesis Pathway edit

^ The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".

References

^ Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA (December 2006). "International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor". Pharmacol. Rev. 58 (4): 742–59. doi:10.1124/pr.58.4.6. PMID 17132852.
^ Lisse TS, Chun RF, Rieger S, Adams JS, Hewison M (June 2013). "Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts". J Bone Miner Res. 28 (6): 1478–14788. doi:10.1002/jbmr.1882. PMID 23362149.
^ Szpirer J, Szpirer C, Riviere M, Levan G, Marynen P, Cassiman JJ, Wiese R, DeLuca HF (September 1991). "The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7". Genomics 11 (1): 168–73. doi:10.1016/0888-7543(91)90114-T. PMID 1662663.
^ Fleet JC, Schoch RD (August 2010). "Molecular Mechanisms for Regulation of Intestinal Calcium Absorption by Vitamin D and Other Factors". Crit Rev Clin Lab Sci 47 (4): 181–195. doi:10.3109/10408363.2010.536429. PMID 21182397.
^ Germain P, Staels B, Dacquet C, Spedding M, Laudet V (December 2006). "Overview of nomenclature of nuclear receptors". Pharmacol. Rev. 58 (4): 685–704. doi:10.1124/pr.58.4.2. PMID 17132848.
^ Adorini L, Daniel KC, Penna G (2006). "Vitamin D receptor agonists, cancer and the immune system: an intricate relationship". Curr Top Med Chem 6 (12): 1297–301. doi:10.2174/156802606777864890. PMID 16848743.
^ "Entrez Gene: VDR vitamin D (1,25- dihydroxyvitamin D3) receptor".
^ Luderer HF, Demay MB (July 2010). "The vitamin D receptor, the skin and stem cells". J. Steroid Biochem. Mol. Biol. 121 (1–2): 314–6. doi:10.1016/j.jsbmb.2010.01.015. PMID 20138991.
^ Lisse TS, Saini V, Zhao H, Luderer HF, Gori F, Demay MB (September 2014). "The Vitamin D Receptor Is Required for Activation of cWnt and Hedgehog Signaling in Keratinocytes". Mol Endocrinol. 28 (10): 1698–1706. doi:10.1210/me.2014-1043. PMID 25180455.
^ Guzey M, Takayama S, Reed JC (December 2000). "BAG1L enhances trans-activation function of the vitamin D receptor". J. Biol. Chem. 275 (52): 40749–56. doi:10.1074/jbc.M004977200. PMID 10967105.
^ ^a ^b ^c ^d ^e Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (June 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.
^ Zhao G, Simpson RU (2010). "Membrane Localization, Caveolin-3 Association and Rapid Actions of Vitamin D Receptor in Cardiac Myocytes". Steroids 75 (8–9): 555–9. doi:10.1016/j.steroids.2009.12.001. PMC 2885558. PMID 20015453.
^ ^a ^b Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (March 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
^ ^a ^b Tagami T, Lutz WH, Kumar R, Jameson JL (December 1998). "The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochem. Biophys. Res. Commun. 253 (2): 358–63. doi:10.1006/bbrc.1998.9799. PMID 9878542.
^ ^a ^b ^c ^d Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M (December 2002). "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. 62 (23): 7050–8. PMID 12460926.
^ Herdick M, Steinmeyer A, Carlberg C (June 2000). "Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators". J. Biol. Chem. 275 (22): 16506–12. doi:10.1074/jbc.M910000199. PMID 10748178.
^ ^a ^b ^c Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN (November 2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". J. Biol. Chem. 276 (44): 40614–20. doi:10.1074/jbc.M106263200. PMID 11514567.
^ He B, Wilson EM (March 2003). "Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
^ ^a ^b Baudino TA, Kraichely DM, Jefcoat SC, Winchester SK, Partridge NC, MacDonald PN (June 1998). "Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription". J. Biol. Chem. 273 (26): 16434–41. doi:10.1074/jbc.273.26.16434. PMID 9632709.
^ Vidal M, Ramana CV, Dusso AS (April 2002). "Stat1-Vitamin D Receptor Interactions Antagonize 1,25-Dihydroxyvitamin D Transcriptional Activity and Enhance Stat1-Mediated Transcription". Mol. Cell. Biol. 22 (8): 2777–87. doi:10.1128/MCB.22.8.2777-2787.2002. PMC 133712. PMID 11909970.
^ Ward JO, McConnell MJ, Carlile GW, Pandolfi PP, Licht JD, Freedman LP (December 2001). "The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor". Blood 98 (12): 3290–300. doi:10.1182/blood.V98.12.3290. PMID 11719366.

External links

Calcitriol Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
Nuclear Receptor Resource
Vitamin D Receptor: Molecule of the Month

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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1. ビタミンD欠乏症の原因および抵抗性 causes of vitamin d deficiency and resistance
2. ビタミンDの代謝 metabolism of vitamin d
3. ビタミンDと骨外健康 vitamin d and extraskeletal health
4. 透析患者における二次性副甲状腺機能亢進症およびミネラル代謝異常のマネージメント management of secondary hyperparathyroidism and mineral metabolism abnormalities in dialysis patients
5. 小児における低カルシウム血症性くる病の病因および治療 etiology and treatment of calcipenic rickets in children

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Der p2 Internalization by Epithelium Synergistically Augments Toll-like Receptor-Mediated Proinflammatory Signaling.

Yin SC1, Liao EC2, Chiu CL3, Chang CY4, Tsai JJ5.
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Calcitriol prevents in vitro vascular smooth muscle cell mineralization by regulating calcium-sensing receptor expression.

Mary A1, Hénaut L, Boudot C, Six I, Brazier M, Massy ZA, Drüeke TB, Kamel S, Mentaverri R.
Endocrinology.Endocrinology.2015 Jun;156(6):1965-74. doi: 10.1210/en.2014-1744. Epub 2015 Mar 12.
Vascular calcification (VC) is a degenerative disease that contributes to cardiovascular morbidity and mortality. A negative relationship has been demonstrated between VC and calcium sensing receptor (CaSR) expression in the vasculature. Of interest, vitamin D response elements, which allow responsi
PMID 25763635

19-Norvitamin D analogs for breast cancer therapy.

Matsumoto Y1, Kittaka A, Chen TC.
Canadian journal of physiology and pharmacology.Can J Physiol Pharmacol.2015 May;93(5):333-48. doi: 10.1139/cjpp-2014-0452. Epub 2015 Mar 6.
The active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3 or calcitriol), is known to inhibit the proliferation and invasiveness of many types of cancer cells, including breast, colon, pancreatic, prostate, and liver cancer cells. These findings support the use of 1α,25(OH)2D3 for th
PMID 25918960

Japanese Journal

副甲状腺機能低下症に対する活性型ビタミンD3療法の指標と評価 (特集内分泌疾患におけるEvidenceに基づいた治療とは?)

福本誠二
内分泌・糖尿病・代謝内科 30(5), 436-441, 2010-05
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Vitamin D and periodontal disease

Amano Yusuke,Komiyama Kazuo,Makishima Makoto
Journal of Oral Science 51(1), 11-20, 2009
… 1,25-dihydroxycholecalciferol or calcitriol] is the active form of vitamin D3, a lipid-soluble vitamin that plays a role in calcium and bone metabolism. … 1,25(OH)2D3 exhibits physiological and pharmacological effects by activating the vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily. …
NAID 130000666175

Related Pictures

★リンクテーブル★

リンク元	「ビタミンD受容体」「ビタミンDレセプター」「カルシトリオール受容体」「カルシトリオールレセプター」「vitamin D receptor」

「ビタミンD受容体」

Vitamin D (1,25- dihydroxyvitamin D3) receptor
	PDB rendering based on 1kb2.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1DB1, 1IE8, 1IE9, 1KB2, 1KB4, 1KB6, 1S0Z, 1S19, 1TXI, 1YNW, 2HAM, 2HAR, 2HAS, 2HB7, 2HB8, 3A2I, 3A2J, 3A3Z, 3A40, 3A78, 3AUQ, 3AUR, 3AX8, 3AZ1, 3AZ2, 3AZ3, 3B0T, 3CS4, 3CS6, 3KPZ, 3M7R, 3OGT, 3P8X, 3TKC, 3VHW, 3W0A, 3W0C, 3W0Y, 3WGP, 3WWR, 4G2I, 4ITE, 4ITF, 4PA2
Identifiers
Symbols	VDR ; NR1I1; PPP1R163
External IDs	OMIM: 601769 MGI: 103076 HomoloGene: 37297 IUPHAR: 605 ChEMBL: 1977 GeneCards: VDR Gene
Gene ontology
Molecular function	• DNA binding; • transcription factor activity, sequence-specific DNA binding; • steroid hormone receptor activity; • protein binding; • zinc ion binding; • calcitriol receptor activity; • lithocholic acid receptor activity; • sequence-specific DNA binding; • retinoid X receptor binding; • vitamin D response element binding; • calcitriol binding; • lithocholic acid binding;
Cellular component	• nucleus; • nucleoplasm; • receptor complex; • RNA polymerase II transcription factor complex;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • cell morphogenesis; • skeletal system development; • transcription initiation from RNA polymerase II promoter; • calcium ion transport; • cellular calcium ion homeostasis; • signal transduction; • lactation; • negative regulation of cell proliferation; • gene expression; • positive regulation of gene expression; • negative regulation of keratinocyte proliferation; • positive regulation of vitamin D 24-hydroxylase activity; • bile acid signaling pathway; • steroid hormone mediated signaling pathway; • positive regulation of keratinocyte differentiation; • negative regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • decidualization; • intestinal absorption; • positive regulation of apoptotic process involved in mammary gland involution; • regulation of calcidiol 1-monooxygenase activity; • mammary gland branching involved in pregnancy; • vitamin D receptor signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;