関: TLR6

WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
ring slowly; "For whom the bell tolls"
a fee levied for the use of roads or bridges (used for maintenance)
charge a fee for using; "Toll the bridges into New York City"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
found pleasant or attractive; often used as a combining form; "a well-liked teacher"

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
〈鐘が〉(にっくり規則的に繰り返して)鳴る / (ゆっくり規則的に繰り返して)〈鐘〉‘を'鳴らす / 〈鐘が〉…‘を'知らせる / 鐘を鳴らすこと / 鐘の音
(橋・道路などの)『使用[通行]料金』,使用税 / (長距離電話などの)『料金』,サービス料 / 《通例単数形で》(災難などの)被害の程度,犠牲(死傷)負数
=sense organ / 受信装置
(…の)『好み』,趣味《+『for』(『to』)+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/06 13:06:45」(JST)

wiki en

Toll-like receptor 6 is a protein that in humans is encoded by the TLR6 gene.^[1] TLR6 has also been designated as CD286 (cluster of differentiation 286).

The protein encoded by this gene is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns (MAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.^[2]

References

^ Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S (Jun 1999). "TLR6: A novel member of an expanding toll-like receptor family". Gene 231 (1–2): 59–65. doi:10.1016/S0378-1119(99)00098-0. PMID 10231569.
^ "Entrez Gene: TLR6 toll-like receptor 6".

External links

Toll-Like Receptor 6 at the US National Library of Medicine Medical Subject Headings (MeSH)
TLR6 human gene location in the UCSC Genome Browser.
TLR6 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

This biochemistry article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy

English Journal

Toll-like receptor 6 gene polymorphisms increase the risk of bovine tuberculosis in Chinese Holstein cattle.

Song Y1, Sun L2, Guo A1, Yang L3.
Acta histochemica.Acta Histochem.2014 Jul 10. pii: S0065-1281(14)00169-X. doi: 10.1016/j.acthis.2014.06.004. [Epub ahead of print]
Our present study aimed to investigate the effect of four SNPs (G1793A, C1859A, A1980G, G1934A) in toll-like receptor 6 (TLR6) on bovine tuberculosis (bTB) resistance in a case-control study. A total of 603 Chinese Holstein cattle (264 from a dairy farm of Henan province, 339 from Hubei province) we
PMID 25017737

Toll-like receptor 6 mediated inflammatory and functional responses of zinc oxide nanoparticles primed macrophages.

Roy R1, Singh SK, Das M, Tripathi A, Dwivedi PD.
Immunology.Immunology.2014 Jul;142(3):453-64. doi: 10.1111/imm.12276.
Macrophages are among the most sensitive immune cells because of their phagocytic activity and are prone to become dysfunctional or not able to perform properly if nanoparticle load increases. We have previously reported that zinc oxide nanoparticles (ZNPs) induce inflammatory responses in macrophag
PMID 24593842

Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: A case control study of north Indian population from Agra (India).

Sinha E1, Biswas SK1, Mittal M1, Bajaj B2, Singh V1, Arela N1, Katoch VM3, Mohanty KK4.
Human immunology.Hum Immunol.2014 Jun 28. pii: S0198-8859(14)00178-5. doi: 10.1016/j.humimm.2014.06.014. [Epub ahead of print]
Infection with Mycobacteriumtuberculosis possibly depends on host genetic factors and is thought to be the major cause of differential susceptibility to the disease. In the present study, 205 pulmonary tuberculosis cases and 127 healthy controls were studied for the association of Toll-like Receptor
PMID 24984237

Japanese Journal

一本鎖核酸を認識するToll様受容体の構造解明及びその応用

YAKUGAKU ZASSHI 136(2), 173-178, 2016
NAID 130005121460

IgA腎症の発症と粘膜免疫 (AYUMI IgA腎症 : 研究と臨床Update)

医学のあゆみ 255(11), 1089-1093, 2015-12-12
NAID 40020675706

Toll-like receptor 5 is not essential for the promotion of secretory immunoglobulin A antibody responses to flagellated bacteria

Microbiology and immunology 59(12), 716-723, 2015-12
NAID 40020687249

「Toll様受容体6」

Toll-like receptor 6
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	4OM7
Identifiers
Symbols	TLR6 ; CD286
External IDs	OMIM: 605403 MGI: 1341296 HomoloGene: 21223 GeneCards: TLR6 Gene
Gene ontology
Molecular function	• receptor activity; • transmembrane signaling receptor activity; • diacyl lipopeptide binding; • protein heterodimerization activity; • lipopeptide binding;
Cellular component	• plasma membrane; • integral component of plasma membrane; • phagocytic vesicle membrane; • Toll-like receptor 2-Toll-like receptor 6 protein complex;
Biological process	• toll-like receptor signaling pathway; • MyD88-dependent toll-like receptor signaling pathway; • inflammatory response; • immune response; • signal transduction; • activation of NF-kappaB-inducing kinase activity; • toll-like receptor 2 signaling pathway; • toll-like receptor 4 signaling pathway; • toll-like receptor 6 signaling pathway; • toll-like receptor TLR1:TLR2 signaling pathway; • toll-like receptor TLR6:TLR2 signaling pathway; • T-helper 1 type immune response; • detection of diacyl bacterial lipopeptide; • defense response to bacterium; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of JUN kinase activity; • innate immune response; • positive regulation of interleukin-6 biosynthetic process; • regulation of cytokine secretion; • cellular response to diacyl bacterial lipopeptide;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;