Toll様受容体6

関: Toll-like receptor 6

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/10 07:05:25」(JST)

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Toll-like receptor 6 is a protein that in humans is encoded by the TLR6 gene.^[3] TLR6 has also been designated as CD286 (cluster of differentiation 286).

The protein encoded by this gene is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns (MAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.^[4]

References

^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S (Jun 1999). "TLR6: A novel member of an expanding toll-like receptor family". Gene. 231 (1–2): 59–65. doi:10.1016/S0378-1119(99)00098-0. PMID 10231569.
^ "Entrez Gene: TLR6 toll-like receptor 6".

External links

Toll-Like Receptor 6 at the US National Library of Medicine Medical Subject Headings (MeSH)
TLR6 human gene location in the UCSC Genome Browser.
TLR6 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

This biochemistry article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy

English Journal

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways.

Huang S, Rutkowsky JM, Snodgrass RG, Ono-Moore KD, Schneider DA, Newman JW, Adams SH, Hwang DH.SourceWestern Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Department of Anatomy, Physiology and Cell Biology, and.
Journal of lipid research.J Lipid Res.2012 Sep;53(9):2002-13. Epub 2012 Jul 4.
Toll-like receptor 4 (TLR4) and TLR2 were shown to be activated by saturated fatty acids (SFAs) but inhibited by docosahexaenoic acid (DHA). However, one report suggested that SFA-induced TLR activation in cell culture systems is due to contaminants in BSA used for solubilizing fatty acids. This rep
PMID 22766885

Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.

Sivula J, Cordova ZM, Tuimala J, Jaatinen T, Partanen J, Volin L, Turpeinen H.SourceFinnish Red Cross Blood Service, Helsinki, Finland Molecular Genetics Department, Hospital Cínico Quirúrgico 'Hermanos Ameijeiras', Havana City, Cuba Helsinki University Central Hospital, Department of Medicine, Division of Hematology, Helsinki, Finland.
Scandinavian journal of immunology.Scand J Immunol.2012 Sep;76(3):336-41. doi: 10.1111/j.1365-3083.2012.02737.x.
Graft-versus-host disease (GvHD) is a major complication in hematopoietic stem cell transplantation (HSCT). The immune response against gut microbes is thought to be an important factor in the beginning of GvHD. Toll-like receptors (TLR) recognize molecular structures of microbes and viruses and pla
PMID 22703024

Japanese Journal

Toll-Like Receptors Required for Dermatophagoides farinae to Activate NF-κB

Kitajima Takaaki,Muroi Masashi,Yamashita Naomi [他],Tanamoto Ken-ichi
Biological and Pharmaceutical Bulletin 37(1), 74-80, 2014
… The excrement extract also activated NF-κB in HEK293 cells expressing TLR1/TLR2, TLR2/TLR6 and CD14/TLR4/MD-2, whereas no activation was observed in cells expressing TLR3, TLR5, TLR7, TLR8 or TLR9. …
NAID 130003382102

Differential Expressions of Toll-Like Receptor Genes in the Vagina of Pregnant Mice

TAKEUCHI Takashi,YOSHIDA Masahiro,SHIMIZU Takuro [他],ASANO Atsushi,SHIMOKAWA Tetsuya,NABETA Motowo,USUI Tatsufumi
Journal of Veterinary Medical Science 75(5), 561-565, 2013
… We found that mRNA expressions of TLR4, TLR5, TLR6, TLR7 and TLR9 were significantly decreased during the late gestation period, whereas temporary increases were seen in the middle gestation period. …
NAID 130002502173

細胞培養系を用いた腸管における酵母の免疫応答刺激活性の解析

三枝静江
東京都農林総合研究センター研究報告 -(7) (-), 1-52, 2012-03
… その応答誘導には,宿主細胞に発現されているパターン認識受容体などを介した微生物の認識が関与しており,酵母を認識する受容体としては,Toll様受容体(Toll-like receptor:TLR)1,TLR2,TLR6,およびDectin-1などが挙げられる。 … 酵母菌体による刺激を行なわない状態にでは,Caco-2細胞では,10mM酪酸添加培地での4日間の培養により,TLR1,TLR6およびDectin-1mRNAの発現量が増加した。 …
NAID 120005331066

Related Pictures

immunohistochemistry for TLR2 and TLR6 TLR6 stable cell line Phenotypic Category immune system, TLR Tube lumineux LED TLR6 Rouge Unfortunately we are unable to provide PBB GE TLR6 207446 at tn.png AP(TLR6 antibody) at dilution of 1:1000 TLR6

★リンクテーブル★

リンク元	「Toll様受容体6」「Toll-like receptor 6」
関連記事	「TL」

「Toll様受容体6」

TLR6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OM7
Identifiers
Aliases	TLR6, CD286, toll like receptor 6
External IDs	OMIM: 605403 MGI: 1341296 HomoloGene: 21223 GeneCards: TLR6
Gene ontology
Molecular function	• Toll-like receptor 2 binding; • protein binding; • receptor activity; • transmembrane signaling receptor activity; • lipopeptide binding;
Cellular component	• integral component of membrane; • phagocytic vesicle membrane; • membrane; • integral component of plasma membrane; • cytoplasmic vesicle; • Golgi apparatus; • membrane raft; • Toll-like receptor 2-Toll-like receptor 6 protein complex; • plasma membrane;
Biological process	• positive regulation of NLRP3 inflammasome complex assembly; • immune system process; • positive regulation of JUN kinase activity; • regulation of cytokine secretion; • cellular response to diacyl bacterial lipopeptide; • activation of NF-kappaB-inducing kinase activity; • toll-like receptor 6 signaling pathway; • interleukin-1 beta secretion; • defense response to bacterium; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • inflammatory response; • toll-like receptor TLR6:TLR2 signaling pathway; • positive regulation of interleukin-6 biosynthetic process; • toll-like receptor signaling pathway; • detection of diacyl bacterial lipopeptide; • signal transduction; • immune response; • innate immune response; • T-helper 1 type immune response; • MyD88-dependent toll-like receptor signaling pathway; • nitric oxide metabolic process; • response to bacterial lipoprotein; • microglial cell activation;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	10333
	21899
	ENSG00000174130
	ENSMUSG00000051498
	Q9Y2C9
	Q9EPW9
	NM_006068
	NM_011604
	NP_006059.2
	NP_035734.3
	Wikidata
View/Edit Human	View/Edit Mouse

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英: Toll-like receptor 6、TLR6
関: Toll様レセプター6

「Toll-like receptor 6」

　　[★]

Toll様受容体6、Toll様レセプター6

関: TLR6

「TL」

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[1] "Human PubMed Reference:".

[2] "Mouse PubMed Reference:".

[pmid10231569-3] Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S (Jun 1999). "TLR6: A novel member of an expanding toll-like receptor family". Gene. 231 (1–2): 59–65. doi:10.1016/S0378-1119(99)00098-0. PMID 10231569.

[4] "Entrez Gene: TLR6 toll-like receptor 6".

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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TLR6