関: Shope fibroma、tumor virus infection

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a benign epithelial tumor forming a rounded mass (同)villoma, papillary_tumor, papillary tumour

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/06 12:53:54」(JST)

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Rabbit with Shope papillomavirus infection.

Engraving from Tableau Encyclopedique et Methodique, 1789.

The cottontail rabbit papilloma virus (CRPV), or Shope papilloma virus (also known as Kappapapillomavirus 2, Cottontail rabbit papillomavirus, and Rabbit (Shope) papilloma virus), is a type I virus under the Baltimore scheme, possessing a nonsegmented dsDNA genome.^[1] The virus was originally separated from horny warts on cottontail rabbits by Richard E. Shope in 1933.^[2] It infects rabbits, causing keratinous carcinomas, typically on or near the animal’s head. These tumors can become large enough that they interfere with the host’s ability to eat, eventually causing starvation.

Shope papilloma virus provided the first mammalian model of a cancer caused by a virus. It takes its name from Shope, who discovered it in the 1930s.^[2] Shope was able to isolate virus particles from tumors on captured animals and use these to inoculate domestic rabbits, which then developed similar tumors.^[3] The virus was sequenced in 1984, showing substantial sequence similarities to HPV1a.^[4] It has been used as a model for human papillomaviruses both before and after this discovery. The most visible example of this role is the HPV vaccine, which was developed based on and incorporating research done using the virus as a model. Similarly, it has been used to investigate antiviral therapies.^[5]

The virus is also a possible source of myths about the jackalope, a rabbit with the horns of an antelope, and related cryptids such as the wolpertinger.^[6]^[7] Stories and illustrations of horned rabbits appear in scientific treatises dating back many years, such as the Tableau encyclopédique et méthodique, from 1789.^[8]

References

^ "Cottontail rabbit papillomavirus" in UniProt
^ ^a ^b Shope RE, Hurst EW (1933). "Infectious papillomatosis of rabbits: with a not on the histopathology". J. Exp. Med. 58 (5): 607–624. doi:10.1084/jem.58.5.607. PMID 19870596.
^ http://www.ratsteachmicro.com/2003_HCOE_PDFs/Papovavirus_Lecture_Outline__2005rev.pdf
^ Giri, Isabelle; Danos, Olivier; Yaniv, Moshe (1985), "Genomic Structure of the Cottontail Rabbit (Shope) Papillomavirus" (PDF), PNAS 82 (6): 1580–1584, doi:10.1073/pnas.82.6.1580
^ Christensen ND, ND (2005), "Genomic Structure of the Cottontail Rabbit (Shope) Papillomavirus", Antivir Chem Chemother 16 (6): 355–62, PMID 16331841
^ Eberhart, George M. "Mysterious Creatures: Creating A Cryptozoological Encyclopedia." 2005. Journal of Scientific Exploration. Vol. 19, No. 1, pp. 103-113
^ Eberhart, George M. (2002), Mysterious Creatures: A Guide to Cryptozoology 1, ABC-CLIO, pp. 237–238, ISBN 1-57607-283-5
^ "Cottontail rabbit papillomavirus was the first mammalian papillomavirus to be discovered"

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Japanese Journal

Shope Papilloma による tRNA の in vitro Methylation

藤村有信
ウイルス 21(1), 15-16, 1971
NAID 130003854477

3.単癌ウサギに於ける補体の動態(第3回補体シンポジウム III 補体とその関連領域)

吉田孝人,伊藤洋平
アレルギー 15(11), 926-927, 947, 1966-11-30
… Immunological experiments employing Shope papilloma-carcinoma system are now being carried out in our group. … In the present paper we report our findings on the alteration of complement value (C'H_<50>) in the tumor-bearing rabbit, which were transplanted with carcinoma (ca) V×2, and (ca) V×7, both being neoplasia of Shope papilloma origin. …
NAID 110002428488

The shope papilloma-carcinoma complex as a model for investigation of tumor immunology and viral oncology.

Evans C.A.
ウイルス 14(1), ????, 1964-02
NAID 40017498027

Related Pictures

★リンクテーブル★

リンク元	「ショープ乳頭腫」「Shope fibroma」「tumor virus infection」「Shope乳頭腫」
拡張検索	「Shope papilloma virus」

「ショープ乳頭腫」

Shope papilloma virus
Virus classification
Group:	Group I (dsDNA)
Family:	Papillomaviridae
Genus:	Kappapapillomavirus
Species:	Kappapapillomavirus 2
Synonyms
	Cottontail rabbit papillomavirus, Cottontail rabbit papillomavirus (Shope), and Rabbit (Shope) papilloma virus