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1. ヒトTリンパ球好性ウイルスI型：ウイルス学、病因、および疫学 human t lymphotropic virus type i virology pathogenesis and epidemiology

English Journal

Spontaneous and experimental malignancies in non-human primates.

Lapin BA1, Yakovleva LA.Author information 1Research Institute of Medical Primatology RAMS, Sochi-Adler, Russia.AbstractContrary to earlier established opinion that tumors in monkeys are found rarely, now the large material confirms that monkey tumors are frequent phenomenon. Tumor incidence clearly increases with age. Frequencies of benign and malignant tumors of various locations and histogenesis are slightly different. Tumors of hematopoietic system are the most frequent. Sporadic cases and enzootic outbreaks of lymphomas are described for different kinds of monkeys, including apes, and probably are caused by viruses. Two viruses were isolated by us from sick monkeys - the retrovirus C-type STLV-1 and the herpes virus papio HVP. Inoculation of virus cultures into monkeys and rabbits induces neoplasms. Monkey neoplasms can be induced by exposure to various chemical agents, and by oncogenic and non-oncogenic viruses. There is no strict species specificity of tumor viruses. The role of polyoma viruses in neoplasms etiology is discussed.
Journal of medical primatology.J Med Primatol.2014 Apr;43(2):100-10. doi: 10.1111/jmp.12098. Epub 2014 Jan 7.
Contrary to earlier established opinion that tumors in monkeys are found rarely, now the large material confirms that monkey tumors are frequent phenomenon. Tumor incidence clearly increases with age. Frequencies of benign and malignant tumors of various locations and histogenesis are slightly diffe
PMID 24392944

Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection.

Miura M, Yasunaga J, Tanabe J, Sugata K, Zhao T, Ma G, Miyazato P, Ohshima K, Kaneko A, Watanabe A, Saito A, Akari H, Matsuoka M1.Author information 1Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Shogoin Kawahara-cho 53, Sakyo-ku, Kyoto 606-8507, Japan. mmatsuok@virus.kyoto-u.ac.jp.AbstractBACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) causes chronic infection leading to development of adult T-cell leukemia (ATL) and inflammatory diseases. Non-human primates infected with simian T-cell leukemia virus type 1 (STLV-1) are considered to constitute a suitable animal model for HTLV-1 research. However, the function of the regulatory and accessory genes of STLV-1 has not been analyzed in detail. In this study, STLV-1 in naturally infected Japanese macaques was analyzed.
Retrovirology.Retrovirology.2013 Oct 24;10:118. doi: 10.1186/1742-4690-10-118.
BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) causes chronic infection leading to development of adult T-cell leukemia (ATL) and inflammatory diseases. Non-human primates infected with simian T-cell leukemia virus type 1 (STLV-1) are considered to constitute a suitable animal model for HTL
PMID 24156738

Delayed seroconversion to STLV-1 infection is associated with mutations in the pol and rex genes.

Dube S1, Saksena N, Spicer T, Healey J, Benz P, Dube DK, Poiesz BJ.Author information 1Division of Hematology/Oncology, Department of Medicine, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA. poieszb@upstate.edu.AbstractBACKGROUND: Simian T-cell lymphoma/leukemia virus-1 (STLV-1) infection of non-human primates can serve as a model for human T-cell lymphoma/leukemia virus infection.
Virology journal.Virol J.2013 Sep 11;10:282. doi: 10.1186/1743-422X-10-282.
BACKGROUND: Simian T-cell lymphoma/leukemia virus-1 (STLV-1) infection of non-human primates can serve as a model for human T-cell lymphoma/leukemia virus infection.METHODS: Two tantalus and 2 patas monkeys were transfused with intraspecies whole blood infected with STLV-1. Infection was determined
PMID 24025129

Japanese Journal

Short communication: epidemiological evidence that simian T-lymphotropic virus type 1 in Macaca fuscata has an alternative transmission route to maternal infection.

Eguchi Katsuyuki,Ohsawa Kazutaka,Fuse Kiyono Mieko,Suzuki Juri,Kurokawa Kenji,Yamamoto Taro
AIDS Research and Human Retroviruses 27(2), 113-114, 2011-02
… Serological inspection of Simian T-lymphotropic Virus Type 1 was conducted for a wild colony of Macaca fuscata, which was captured in the middle Honshu, Japan. … This finding suggests that, in contrast with human T-lymphotropic Virus Type 1, horizontal transmission play an important role in increasing prevalence of STLV-1 with age among M. …
NAID 120003751814

Characterization of a new simian T-lymphotropic virus type 1 (STLV-1) in a wild living chimpanzee (Pan troglodytes verus) from Ivory Coast : Evidence of a new STLV-1 group?

LEENDERTZ FH
AIDS Res Hum Retrov 19, 255-258, 2003
NAID 30018199482

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