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Androgen Receptor Coactivators in Regulation of Growth and Differentiation in Prostate Cancer.

Culig Z1.
Journal of cellular physiology.J Cell Physiol.2016 Feb;231(2):270-4. doi: 10.1002/jcp.25099.
Androgen receptor (AR) is a key factor in regulation of growth and differentiation in normal and malignant prostate. Endocrine therapies for prostate cancer include inhibition of androgen production either by analogs of luteinizing hormone releasing hormone or abiraterone acetate and/or use of anti-
PMID 26201947

Dose-dependent regulation of steroid receptor coactivator-1 and steroid receptors by testosterone propionate in the hippocampus of adult male mice.

Qiu L1, Zhao Y2, Guo Q2, Zhang Y2, He L1, Li W3, Zhang J4.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2015 Nov 26;156:23-31. doi: 10.1016/j.jsbmb.2015.11.012. [Epub ahead of print]
Androgens have been proposed to play important roles in the regulation of hippocampus function either directly, through the androgen receptor (AR), or indirectly, through estrogen receptors (ERs), after aromatization into estradiol. Steroid receptor coactivator-1 (SRC-1) is present in the hippocampu
PMID 26607693

Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancer.

Chandran K1, Goswami S1, Sharma-Walia N1.
Oncotarget.Oncotarget.2015 Nov 26. doi: 10.18632/oncotarget.6402. [Epub ahead of print]
Inflammatory and invasive breast cancers are aggressive and require better understanding for the development of new treatments and more accurate prognosis. Here, we detected high expression of PPARα in human primary inflammatory (SUM149PT) and highly invasive (SUM1315MO2) breast cancer cells, and t
PMID 26621841

Modulation of Coactivator Recruitment by Cooperative Ligand Binding to Human Estrogen Receptor α and β(Analytical Biochemistry)

Suzuki Sachiko,Nishida Satoshi,Ohno Ken-ichi [他],SANTA Tomofumi
Biological & pharmaceutical bulletin 30(9), 1641-1647, 2007-09-01
… We therefore hypothesized that ligand-binding characteristics influence coactivator recruitment to the ER dimer, and thereby affect transcriptional activity. … We investigated the interaction between ER and human Steroid Receptor Coactivator-1 (SRC-1), in the presence of compounds exhibiting various Hill coefficients. …
NAID 110006380242