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- the 19th letter of the Roman alphabet (同)s
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- sulfurの化学記号 / {略}South[ern]
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/25 22:25:12」(JST)
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- 1. 感染性心内膜炎の臨床症状および診断 clinical manifestations and diagnosis of infective endocarditis
- 2. 固有弁心内膜炎の抗菌療法 antimicrobial therapy of native valve endocarditis
- 3. 感染性心内膜炎の疫学、危険因子および微生物学 epidemiology risk factors and microbiology of infective endocarditis
- 4. 感染性心内膜炎の合併症および転帰 complications and outcome of infective endocarditis
- 5. 小児における感染性心内膜炎 infective endocarditis in children
English Journal
- Regulation of the Function of the Human ABCG2 Multidrug Transporter by Cholesterol and Bile Acids: Effects of Mutations in Potential Substrate and Steroid Binding Sites.
- Telbisz A1, Hegedüs C, Váradi A, Sarkadi B, Ozvegy-Laczka C.Author information 1Institute of Molecular Pharmacology, Research Centre for Natural Sciences, Hungarian Academy of Sciences (A.T., B.S.); Molecular Biophysics Research Group, Hungarian Academy of Sciences and Semmelweis University (C.H.); and Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences (A.V., C.O.-L.), Budapest, Hungary.AbstractABCG2 (ATP-binding cassette, subfamily G, member 2) is a plasma membrane glycoprotein that actively extrudes xenobiotics and endobiotics from the cells and causes multidrug resistance in cancer. In the liver, ABCG2 is expressed in the canalicular membrane of hepatocytes and excretes its substrates into the bile. ABCG2 is known to require high membrane cholesterol content for maximal activity, and by examining purified ABCG2 reconstituted in proteoliposomes we have recently shown that cholesterol is an essential activator, while bile acids significantly modify the activity of this protein. In the present work, by using isolated insect cell membrane preparations expressing human ABCG2 and its mutant variants, we have analyzed whether certain regions in this protein are involved in sterol recognition. We found that replacing ABCG2-R482 with large amino acids does not affect cholesterol dependence, but changes to small amino acids cause altered cholesterol sensitivity. When leucines in the potential steroid-binding element (SBE, aa 555-558) of ABCG2 were replaced by alanines, cholesterol dependence of ABCG2 activity was strongly reduced, although the L558A mutant variant when purified and reconstituted still required cholesterol for full activity. Regarding the effect of bile acids in isolated membranes, we found that these compounds decreased ABCG2-ATPase in the absence of drug substrates, which did not significantly affect substrate-stimulated ATPase activity. These ABCG2 mutant variants also altered bile acid sensitivity, although cholic acid and glycocholate were not transported by the protein. We suggest that the aforementioned two regions in ABCG2 are important for sterol sensing and may represent potential targets for pharmacologic modulation of ABCG2 function.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2014 Apr;42(4):575-85. doi: 10.1124/dmd.113.055731. Epub 2014 Jan 2.
- ABCG2 (ATP-binding cassette, subfamily G, member 2) is a plasma membrane glycoprotein that actively extrudes xenobiotics and endobiotics from the cells and causes multidrug resistance in cancer. In the liver, ABCG2 is expressed in the canalicular membrane of hepatocytes and excretes its substrates i
- PMID 24384916
- Examining the Cost-Effectiveness of Radiation Therapy Among Older Women With Favorable-Risk Breast Cancer.
- Sen S1, Wang SY, Soulos PR, Frick KD, Long JB, Roberts KB, Yu JB, Evans SB, Chagpar AB, Gross CP.Author information 1Affiliations of authors: Cancer Outcomes, Public Policy and Effectiveness Research (COPPER) Center, Yale Cancer Center (SS, S-YW, PRS, JBL, KBR, JBY, SBE, ABC, CPG), Department of Epidemiology and Public Health (S-YW), Section of General Internal Medicine, Department of Internal Medicine (PRS, JBL, CPG), Department of Therapeutic Radiology (KBR, JBY, SBE), and Department of Surgery (ABC), Yale University School of Medicine, New Haven, CT; Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD (KDF).AbstractBACKGROUND: Little is known about the cost-effectiveness of external beam radiation therapy (EBRT) or newer radiation therapy (RT) modalities such as intensity modulated radiation (IMRT) or brachytherapy among older women with favorable-risk breast cancer.
- Journal of the National Cancer Institute.J Natl Cancer Inst.2014 Mar 5. [Epub ahead of print]
- BACKGROUND: Little is known about the cost-effectiveness of external beam radiation therapy (EBRT) or newer radiation therapy (RT) modalities such as intensity modulated radiation (IMRT) or brachytherapy among older women with favorable-risk breast cancer.METHODS: Using a Markov model, we estimated
- PMID 24598714
- Aerococcus christensenii native aortic valve subacute bacterial endocarditis (SBE) presenting as culture negative endocarditis (CNE) mimicking marantic endocarditis.
- Jose A1, Cunha BA2, Klein NC3, Schoch PE4.Author information 1Infectious Disease Division, Winthrop-University Hospital, Mineola, NY, USA.2Infectious Disease Division, Winthrop-University Hospital, Mineola, NY, USA; State University of New York, School of Medicine, Stony Brook, NY, USA. Electronic address: bacunha@winthrop.org.3Infectious Disease Division, Winthrop-University Hospital, Mineola, NY, USA; State University of New York, School of Medicine, Stony Brook, NY, USA.4Microbiology Laboratory, Winthrop-University Hospital, Mineola, NY, USA.AbstractThis is a case report of an adult who presented with apparent culture negative endocarditis (CNE) thought to be marantic endocarditis due to a B-cell lymphoproliferative disorder. This was a most perplexing case and was eventually diagnosed as subacute bacterial endocarditis (SBE) due to a rare slow growing organism. Against the diagnosis of SBE was the lack of fever, hepatomegaly, peripheral manifestations and microscopic hematuria. Also, against a diagnosis of SBE was another explanation for the patient's abnormal findings, e.g., elevated ferritin levels, elevated α1/α2 globulins on SPEP, an elevated alkaline phosphatase, flow cytometry showing B-lymphocytes expressing CD5, and a bone lesion in the right iliac. Findings compatible with both SBE and marantic endocarditis due to a B-cell lymphoproliferative disorder included an elevated ESR, and splenomegaly. Blood cultures eventually became positive during hospitalization. We report a case of native aortic valve (AV) subacute bacterial endocarditis (SBE) due to Aerococcus christensenii mimicking marantic endocarditis due to a B-cell lymphoproliferative disorder. To the best of our knowledge, this is the first reported case of native AV SBE due to A. christensenii presenting as marantic endocarditis.
- Heart & lung : the journal of critical care.Heart Lung.2014 Mar-Apr;43(2):161-3. doi: 10.1016/j.hrtlng.2013.11.005. Epub 2013 Nov 23.
- This is a case report of an adult who presented with apparent culture negative endocarditis (CNE) thought to be marantic endocarditis due to a B-cell lymphoproliferative disorder. This was a most perplexing case and was eventually diagnosed as subacute bacterial endocarditis (SBE) due to a rare slow
- PMID 24341951
Japanese Journal
- バルーン内視鏡を用いた大腸内視鏡挿入法のコツ
- 竹澤 敬人,矢野 智則,砂田 圭二郎,山本 博徳
- 日本消化器内視鏡学会雑誌 56(6), 2000-2010, 2014
- … のがバルーン内視鏡（Balloon-assisted endoscopy：BAE）である．BAEには，ダブルバルーン内視鏡（Double-balloon endoscopy：DBE）とシングルバルーン内視鏡（Single-balloon endoscopy：SBE）がある．BAEは，深部小腸の観察をする目的で開発された．DBEとSBEは，大腸内視鏡に応用することができる．当院ではほとんどの症例をDBEで行っている．DBEでは行う前の準備がまず大切である．DBEとして使用できるスコープは3種類 …
- NAID 130004555345
- Short typeシングルバルーン内視鏡を用いてバルーン拡張術を施行したIPMN術後膵管空腸吻合部狭窄の1例
- 矢根 圭,真口 宏介,小山内 学,高橋 邦幸,潟沼 朗生,金 俊文,高木 亮,松本 和幸,権 勉成,松森 友昭,友成 暁子
- 日本消化器内視鏡学会雑誌 56(3), 477-483, 2014
- … した．2011年6月（術後19カ月）のCTにて残膵主膵管の拡張と内部の淡い高吸収域を認め，IPMN再発と膵管空腸吻合部狭窄の鑑別を要した．同年7月に急性膵炎を発症し，プロトタイプシングルバルーン内視鏡（Short SBE）による吻合部の観察を試みたが同定困難であった．2012年2月の再検時には先端フードを装着し詳細に観察することで，狭窄した膵管空腸吻合部の同定が可能となった．バルーンによる吻合部の拡張術を施行 …
- NAID 130003395974
- バルーン内視鏡 (特集 消化器領域における診断内視鏡 : モダリティの進歩とその活用法) -- (内視鏡機器の進歩と活用法)
- 山田 篤生,渡部 宏嗣,木暮 宏史 [他]
- 内科 111(3), 479-485, 2013-03
- NAID 40019596970
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★リンクテーブル★
| リンク元 | 「ABE」「standard base excess」「亜急性細菌性心内膜炎」「subacute bacterial endocarditis」 |
| 拡張検索 | 「SSBE」「LSBE」 |
| 関連記事 | 「S」 |
「ABE」
- 急性細菌性心内膜炎 acute bacterial endocarditis
- actual base exess ≒ BE ⇔ standard base excess SBE
「standard base excess」
参考
- 1.
「亜急性細菌性心内膜炎」
「subacute bacterial endocarditis」
「SSBE」
[★] short-segmentバレット食道, short segment Barrett esophagus：3cm以下のバレット食道
「LSBE」
- 同
- long segment Barrett esophagus
- 関
- バレット食道
- 3cm以上のバレット食道
「S」