WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
Nazi militia created by Hitler in 1921 that helped him to power but was eclipsed by the SS after 1943 (同)Sturmabteilung, Storm Troops
the 19th letter of the Roman alphabet (同)s

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蛋白(たんばく)質
sulfurの化学記号 / {略}South[ern]

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1. 心血管疾患におけるＣ－反応性蛋白 c reactive protein in cardiovascular disease
2. Protein S deficiency
3. Protein C deficiency
4. Factor V Leiden and activated protein C resistance
5. 急性期反応物質 acute phase reactants

English Journal

Metastasis-associated protein S100A4 induces a network of inflammatory cytokines that activate stromal cells to acquire pro-tumorigenic properties.

Bettum IJ1, Vasiliauskaite K1, Nygaard V1, Clancy T1, Pettersen SJ1, Tenstad E2, Mælandsmo GM3, Prasmickaite L4.Author information 1Department of Tumor Biology, Institute for Cancer Research, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway.2Department of Tumor Biology, Institute for Cancer Research, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; The K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.3Department of Tumor Biology, Institute for Cancer Research, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Institute for Pharmacy, Faculty of Health Science, University of Tromsø, Tromsø, Norway.4Department of Tumor Biology, Institute for Cancer Research, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway. Electronic address: linap@rr-research.no.AbstractTumor cells have the ability to exploit stromal cells to facilitate metastasis. By using malignant melanoma as a model, we show that the stroma adjacent to metastatic lesions is enriched in the known metastasis-promoting protein S100A4. S100A4 stimulates cancer cells to secrete paracrine factors, such as inflammatory cytokines IL8, CCL2 and SAA, which activate stromal cells (endothelial cells and monocytes) so that they acquire tumor-supportive properties. Our data establishes S100A4 as an inducer of a cytokine network enabling tumor cells to engage angiogenic and inflammatory stromal cells, which might contribute to pro-metastatic activity of S100A4.
Cancer letters.Cancer Lett.2014 Mar 1;344(1):28-39. doi: 10.1016/j.canlet.2013.10.036. Epub 2013 Nov 8.
Tumor cells have the ability to exploit stromal cells to facilitate metastasis. By using malignant melanoma as a model, we show that the stroma adjacent to metastatic lesions is enriched in the known metastasis-promoting protein S100A4. S100A4 stimulates cancer cells to secrete paracrine factors, su
PMID 24215866

Expression profiles of 507 proteins from a biotin label-based antibody array in human colorectal cancer.

Miyoshi H1, Morishita A1, Tani J1, Sakamoto T1, Fujita K1, Katsura A1, Tatsuta M1, Nomura T1, Yoneyama H1, Iwama H2, Suzuki Y3, Masaki T1.Author information 1Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Kita-gun, Kagawa 761-0793, Japan.2Life Science Research Center, Kagawa University Faculty of Medicine, Kita-gun, Kagawa 761-0793, Japan.3Department of Gastroenterological Surgery, Kagawa University Faculty of Medicine, Kita-gun, Kagawa 761-0793, Japan.AbstractMolecular-targeted therapy is one of the most promising therapies for patients with advanced-stage colorectal cancer (CRC). However, a wide range of proteins have unknown expression levels in CRC. The purpose of the present study was to determine the expression levels of various proteins related to colorectal carcinogenesis and cancer development. We examined the expression levels of 507 target proteins using a biotin label-based antibody array in 6 human CRC tissues. We also analyzed the clinicopathological features of CRC patients. In CRC tissues, IL-1α, GRO, Glut5, MIG, ICAM-5, VE-cadherin, uPA and Leptin R were increased when compared to levels in normal colon tissues. MPIF-1/CCL23, FGF R5, MIP2, SAA and IL-18 Rβ were strongly upregulated in rectal cancer when compared to the levels in non-rectal cancer. These data suggest that differential protein expression profiles exist under different conditions, including carcinogenesis and CRC localization. Therefore, an exhaustive analysis of protein expression levels using a biotin label-based antibody protein array is a potentially useful tool for identifying novel individual therapies for CRC patients.
Oncology reports.Oncol Rep.2014 Mar;31(3):1277-81. doi: 10.3892/or.2013.2935. Epub 2013 Dec 19.
Molecular-targeted therapy is one of the most promising therapies for patients with advanced-stage colorectal cancer (CRC). However, a wide range of proteins have unknown expression levels in CRC. The purpose of the present study was to determine the expression levels of various proteins related to
PMID 24366523

Urinary Sulfur Metabolites Associate with a Favorable Cardiovascular Risk Profile and Survival Benefit in Renal Transplant Recipients.

van den Berg E, Pasch A, Westendorp WH, Navis G, Brink EJ, Gans RO, van Goor H, Bakker SJ.Author information Top Institute Food and Nutrition, Wageningen, The Netherlands;AbstractIn post-transplant conditions, sulfur may be protective by intermediate conversion to hydrogen sulfide and thiosulfate. However, sulfate, the end product of sulfur-containing amino acids (SAAs), contributes to metabolic acid load and may adversely influence acid-base homeostasis. We investigated the association of urinary sulfur metabolites with cardiometabolic parameters in renal transplant recipients (RTRs) and analyzed their predictive capacity for mortality. We studied urinary sulfate and thiosulfate excretion in 24-hour urine samples from 707 RTRs at a median 5.4 years (interquartile range, 1.9 to 12.2) after transplantation as well as from 110 controls. Diet was assessed for SAA content and various risk factors were measured. Urinary sulfate was similar, whereas thiosulfate was higher in RTRs versus controls. SAA intake was lower in RTRs compared with controls and correlated with sulfate but not thiosulfate excretion. Sulfate beneficially associated with eGFR, net acid excretion, systolic BP, high-sensitivity C-reactive protein, N-terminal probrain natriuretic peptide, and proteinuria (all P≤0.01). Thiosulfate beneficially associated with eGFR, serum acidity, high-sensitivity C-reactive protein, and N-terminal probrain natriuretic peptide (all P≤0.001). During a median 27 months (interquartile range, 22-36) of follow-up, 47 RTRs died. After adjustment for age, sex, and eGFR, hazard ratios for mortality were 0.87 (95% confidence interval, 0.82 to 0.92; P<0.001) for urinary sulfate and 0.60 (95% confidence interval, 0.41 to 0.59; P=0.01) for thiosulfate. Thus, despite the association of urinary sulfate with metabolic acid load, urinary sulfate and thiosulfate beneficially associated with survival in RTRs, possibly by influencing cardiovascular parameters. Intervention studies with exogenous sulfur are warranted to elucidate mechanisms underlying these promising associations in RTRs.
Journal of the American Society of Nephrology : JASN.J Am Soc Nephrol.2014 Feb 7. [Epub ahead of print]
In post-transplant conditions, sulfur may be protective by intermediate conversion to hydrogen sulfide and thiosulfate. However, sulfate, the end product of sulfur-containing amino acids (SAAs), contributes to metabolic acid load and may adversely influence acid-base homeostasis. We investigated the
PMID 24511127