WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
tall woody perennial grasses with hollow slender stems especially of the genera Arundo and Phragmites
a vibrator consisting of a thin strip of stiff material that vibrates to produce a tone when air streams over it; "the clarinetist fitted a new reed onto his mouthpiece" (同)vibrating reed
United States journalist who reported on the October Revolution from Petrograd in 1917; founded the Communist Labor Party in America in 1919; is buried in the Kremlin in Moscow (1887-1920) (同)John Reed
United States physician who proved that yellow fever is transmitted by mosquitoes (1851-1902) (同)Walter Reed

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(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
『アシ』,ヨシ;《複数形で》(屋根ふきに用いる)乾燥したアシ(ヨシ)の茎 / アシ笛,牧笛(アシなどの茎で作ったもの) / リード,舌(クラリネットやオーボエなどの吹口についている薄片) / リード楽(リードの震動で音を出す管楽器;クラリネットやオーボエなど)
rheniumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/01/05 18:08:45」(JST)

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Micrograph showing a classic Reed–Sternberg cell

Micrograph showing a "popcorn cell", the Reed–Sternberg cell variant seen in nodular lymphocyte predominant Hodgkin lymphoma.H&E stain

Reed–Sternberg cells (also known as lacunar histiocytes for certain types) are different giant cells found with light microscopy in biopsies from individuals with Hodgkin's lymphoma (a.k.a. Hodgkin's disease, a type of lymphoma). They are usually derived from B lymphocytes, classically considered crippled germinal center B cells, meaning they have not undergone hypermutation to express their antibody. Seen against a sea of B cells, they give the tissue a moth-eaten appearance.^[1]

Classification of Hodgkin's is based on the reactive cell mixture. Immunomarkers are used (e.g., CD15 and CD30).

Reed–Sternberg cells are large (30–50 microns) and are either multinucleated or have a bilobed nucleus with prominent eosinophilic inclusion-like nucleoli (thus resembling an "owl's eye" appearance). Reed–Sternberg cells are CD30 and CD15 positive, usually negative for CD20 and CD45. The presence of these cells is necessary in the diagnosis of Hodgkin's lymphoma – the absence of Reed–Sternberg cells has very high negative predictive value. They can also be found in reactive lymphadenopathy (such as infectious mononucleosis immunoblasts which are RS like in appearance, carbamazepine associated lymphadenopathy) and very rarely in other types of non-Hodgkin lymphomas. Anaplastic large cell lymphoma may show RS-like cells as well.

History

They are named after Dorothy Reed Mendenhall and Carl Sternberg, who provided the first definitive microscopic descriptions of Hodgkin's disease.^[2]^[3]

Pathology

Hodgkin's lymphoma

A special type of Reed–Sternberg cells (RSCs) is the lacunar histiocyte, whose cytoplasm retracts when fixed in formalin, so the nuclei give the appearance of cells that lie with empty spaces (called lacunae) between them.^[4] These are characteristic of the nodular sclerosis subtype of Hodgkin's lymphoma.^[4]

Mummified RSCs (compact nucleus, basophilic cytoplasm, no nucleolus) are also associated with classical Hodgkin's lymphoma while popcorn cells (small cell with hyper-lobulated nucleus and small nucleoli) are lymphohistiocytic (L-H) variant of Reed Sternberg cells and are associated with nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL).

RSCs and one RSC cell line (L1236 cells) but not other RSC cell lines express very high levels of ALOX15 (i.e., 15-lipoxygenase-1) or possibly ALOX15B (i.e. 15-lipoxygenase-2), enzymes that metabolize arachidonic acid and various other polyunsaturated fatty acids to a wide array of bioactive products including in particular those of the 15-Hydroperoxyeicosatetraenoic acid family of arachidonic acid metabolites. This is unusual in that lymphocytes typically express little or no ALOX15. It is suggested that ALOX15 and/or ALOX15B, perhaps operating through one of its arachidonic acid-derived products, the eoxins, contributes to the development and/or morphology of Hodgkin's lymphoma.^[5]^[6]^[7]^[8]

References

^ Hartlapp I, Pallasch C, Weibert G, Kemkers A, Hummel M, Re D (February 2009). "Depsipeptide induces cell death in Hodgkin lymphoma-derived cell lines". Leuk. Res. 33 (7): 929–36. doi:10.1016/j.leukres.2008.12.013. PMID 19233470.
^ Reed D. On the pathological changes in Hodgkin's disease, with special reference to its relation to tuberculosis. Johns Hopkins Hosp Rep 1902;10:133–96.
^ Sternberg C. Uber eine eigenartige unter dem Bilde der Pseudoleukamie verlaufende Tuberculose des lymphatischen Apparates. Ztschr Heilk 1898;19:21–90.
^ ^a ^b Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
^ FEBS J. 2008 Aug;275(16):4222–34. doi: 10.1111/j.1742-4658.2008.06570
^ Prostaglandins Other Lipid Mediat. 2009 Sep;89(3–4):120–5. doi: 10.1016/j.prostaglandins.2008.12.003
^ Exp Cell Res. 2012 Feb 1;318(3):169–76. doi: 10.1016/j.yexcr.2011.10.017
^ Exp Hematol. 2010 Feb;38(2):116–23. doi: 10.1016/j.exphem.2009

UpToDate Contents

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1. リードスタンバーグ細胞およびホジキンリンパ腫の病因 the reed sternberg cell and the pathogenesis of hodgkin lymphoma
2. 古典型ホジキンリンパ腫の疫学、病理学的特徴、および診断 epidemiology pathologic features and diagnosis of classical hodgkin lymphoma
3. 慢性リンパ性白血病の病期分類および予後 staging and prognosis of chronic lymphocytic leukemia
4. 成人における古典的ホジキンリンパ腫の初期評価および診断 initial evaluation and diagnosis of classical hodgkin lymphoma in adults
5. 結節性リンパ球優位型ホジキンリンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of nodular lymphocyte predominant hodgkin lymphoma

English Journal

Classical Hodgkin lymphoma, lymphocyte depleted type: Clinicopathological analysis and prognostic comparison with other types of classical Hodgkin lymphoma.

Karube K, Niino D, Kimura Y, Ohshima K.SourceDepartment of Pathology, School of Medicine, Kurume University, Kurume, Japan; Division of Molecular Medicine, Aichi Cancer Center Research Institute, Japan. Electronic address: karube1975@aichi-cc.jp.
Pathology, research and practice.Pathol Res Pract.2013 Mar 8. pii: S0344-0338(12)00328-7. doi: 10.1016/j.prp.2012.11.003. [Epub ahead of print]
The lymphocyte-depleted type (LD) is a morphological subtype of classical Hodgkin lymphoma (CHL), but its rarity and heterogeneous morphological character makes a definite clinicopathological identification difficult. To characterize this disease, LD cases were compared with other types of CHL. From
PMID 23478005

Aberrant T-cell antigen expression in classical Hodgkin lymphoma is associated with decreased event-free survival and overall survival.

Venkataraman G, Song JY, Tzankov A, Dirnhofer S, Heinze G, Kohl M, Traverse-Glehen A, Eberle FC, Hanson JC, Raffeld MA, Pittaluga S, Jaffe ES.SourceHematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;
Blood.Blood.2013 Mar 7;121(10):1795-804. doi: 10.1182/blood-2012-06-439455. Epub 2013 Jan 10.
Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) rarely express T-cell-associated antigens (TCA), but the clinical significance of this finding is uncertain. Fifty cHLs expressing any TCA on the HRS cells (TCA-cHL) were identified in two cohorts (National Cancer Institute, n =
PMID 23305738

Unclassifiable B-cell lymphoma occurring after necrotizing pneumonia.

Cogen A, Bries G, Verbeke S, Van Schil P.SourceDepartment of Thoracic and Vascular Surgery, Antwerp University Hospital, Edegem (Antwerp), Belgium.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.Eur J Cardiothorac Surg.2013 Mar;43(3):e89-91. doi: 10.1093/ejcts/ezs611. Epub 2012 Dec 7.
We report a case of CD20+ grey zone lymphoma (GZL) with Reed Sternberg cells as an unexpected pathological diagnosis of a destroyed right lower lobe after necrotizing pneumonia. These GZLs show overlapping features of classical Hodgkin's lymphoma and diffuse large B-cell lymphoma. GZLs are a rare sp
PMID 23220936

Japanese Journal

The side population, as a precursor of Hodgkin and Reed-Sternberg cells and a target for nuclear factor-κB inhibitors in Hodgkin's lymphoma

NAKASHIMA Makoto,ISHII Yumiko,WATANABE Mariko,TOGANO Tomiteru,UMEZAWA Kazuo,HIGASHIHARA Masaaki,WATANABE Toshiki,HORIE Ryouichi
Cancer science 101(11), 2490-2496, 2010-11-10
NAID 10027834044

Hodgkin リンパ腫(その理解の進歩と病理診断)

田丸淳一
診断病理 : Japanese journal of diagnostic pathology 26(4), 213-221, 2009-10-31
NAID 10025621767

Epstein-Barr virus-positive diffuse large B-cell lymphoma carrying a t(9;14)(p13;q32) translocation

OHNO Hitoshi,NISHIKORI Momoko,HAGA Hironori,ISODA Kotaro
International journal of hematology 89(5), 704-708, 2009-06-15
NAID 10025162182

Related Pictures

★リンクテーブル★

リンク元	「リード・シュテルンベルグ細胞」「リード・シュテルンベルク細胞」
拡張検索	「Reed-Sternberg cells」
関連記事	「Re」「cell」

「リード・シュテルンベルグ細胞」

　　[★]

英: Reed-Sternberg cell, RS, Reed-Sternberg giant cells
同: Reed-Sternberg細胞、Reed-Sternberg巨細胞、ドロシー・リード細胞, Dorothy Reed cell, Dorothy Reed cells、ステルンベルグ巨細胞 Sternberg giant cell、ステルンベルグ-リード細胞 Sternberg-Reed cell、ステルンベルグ巨細胞 Sternberg giant cell
関: ホジキンリンパ腫、ホジキン細胞

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