WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
tall woody perennial grasses with hollow slender stems especially of the genera Arundo and Phragmites
a vibrator consisting of a thin strip of stiff material that vibrates to produce a tone when air streams over it; "the clarinetist fitted a new reed onto his mouthpiece" (同)vibrating reed
United States journalist who reported on the October Revolution from Petrograd in 1917; founded the Communist Labor Party in America in 1919; is buried in the Kremlin in Moscow (1887-1920) (同)John Reed
United States physician who proved that yellow fever is transmitted by mosquitoes (1851-1902) (同)Walter Reed

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(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
『アシ』,ヨシ;《複数形で》(屋根ふきに用いる)乾燥したアシ(ヨシ)の茎 / アシ笛,牧笛(アシなどの茎で作ったもの) / リード,舌(クラリネットやオーボエなどの吹口についている薄片) / リード楽(リードの震動で音を出す管楽器;クラリネットやオーボエなど)
rheniumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/04 18:58:43」(JST)

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Micrograph showing a classic Reed–Sternberg cell.

Micrograph showing a "popcorn cell", the Reed–Sternberg cell variant seen in nodular lymphocyte predominant Hodgkin lymphoma.H&E stain.

Reed–Sternberg cells (also known as lacunar histiocytes for certain types) are different giant cells found with light microscopy in biopsies from individuals with Hodgkin's lymphoma (aka Hodgkin's disease; a type of lymphoma). They are usually derived from B lymphocytes, classically considered crippled germinal center B cells, meaning they have not undergone hypermutation to express their antibody. Seen against a sea of B cells, they give the tissue a moth-eaten appearance.^[1]

They are named after Dorothy Reed Mendenhall and Carl Sternberg, who provided the first definitive microscopic descriptions of Hodgkin's disease.^[2]^[3]

Classification of Hodgkin's is based on the reactive cell mixture. Immunomarkers are used eg. CD 15 and 30.

Reed–Sternberg cells are large and are either multinucleated or have a bilobed nucleus with prominent eosinophilic inclusion-like nucleoli (thus resembling an "owl's eye" appearance). Reed–Sternberg cells are CD30 and CD15 positive, usually negative for CD20 and CD45. The presence of these cells is necessary in the diagnosis of Hodgkin's lymphoma – the absence of Reed–Sternberg cells has very high negative predictive value. They can also be found in reactive lymphadenopathy (such as infectious mononucleosis, carbamazepine associated lymphadenopathy) and very rarely in other types of non-Hodgkin lymphomas.

A special type of Reed–Sternberg cells (RSCs) is the lacunar histiocyte, whose cytoplasm retracts when fixed in formalin, so the nuclei give the appearance of cells that lie with empty spaces (called lacunae) between them.^[4] These are characteristic of the nodular sclerosis subtype of Hodgkin's lymphoma.^[4]

Mummified RSCs (compact nucleus, basophilic cytoplasm, no nucleolus) are also associated with classical Hodgkin's lymphoma while popcorn cells (small cell with hyper-lobulated nucleus and small nucleoli) are lymphohistiocytic (L-H) variant of Reed Sternberg cells and are associated with Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL).

References

^ Hartlapp I, Pallasch C, Weibert G, Kemkers A, Hummel M, Re D (February 2009). "Depsipeptide induces cell death in Hodgkin lymphoma-derived cell lines". Leuk. Res. 33 (7): 929–36. doi:10.1016/j.leukres.2008.12.013. PMID 19233470.
^ Reed D. On the pathological changes in Hodgkin's disease, with special reference to its relation to tuberculosis. Johns Hopkins Hosp Rep 1902;10:133-96.
^ Sternberg C. Uber eine eigenartige unter dem Bilde der Pseudoleukamie verlaufende Tuberculose des lymphatischen Apparates. Ztschr Heilk 1898;19:21–90.
^ ^a ^b Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.

UpToDate Contents

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1. リードスタンバーグ細胞およびホジキンリンパ腫の病因 the reed sternberg cell and the pathogenesis of hodgkin lymphoma
2. 古典型ホジキンリンパ腫の疫学、病理学的特徴、および診断 epidemiology pathologic features and diagnosis of classical hodgkin lymphoma
3. 小児および思春期におけるホジキンリンパ腫の概要 overview of hodgkin lymphoma in children and adolescents
4. 成人における古典的ホジキンリンパ腫の初期評価および診断 initial evaluation and diagnosis of classical hodgkin lymphoma in adults
5. ホジキンリンパ腫におけるエプスタイン・バール・ウイルス the role of epstein barr virus in hodgkin lymphoma

English Journal

A novel PTPN1 splice variant upregulates JAK/STAT activity in classical Hodgkin's lymphoma cells.

Zahn M1, Marienfeld R1, Melzner I1, Heinrich J1, Renner B1, Wegener S1, Mießner A1, Barth TF1, Dorsch K1, Brüderlein S1, Möller P2.
Blood.Blood.2017 Jan 12. pii: blood-2016-06-720516. doi: 10.1182/blood-2016-06-720516. [Epub ahead of print]
Chronic activation of the Janus kinase (JAK)/ Signal Transducer and Activator of Transcription (STAT) signaling pathways is a hallmark of a variety of B cell lymphomas including classical Hodgkin's lymphoma (cHL). Constitutive JAK/STAT signaling is crucial for survival and proliferation of Hodgkin/R
PMID 28082443

Exposing Hodgkin-Reed-Sternberg cells.

Steidl C1.
Blood.Blood.2017 Jan 5;129(1):6-7. doi: 10.1182/blood-2016-11-746701.
PMID 28057670

Chronic Lymphocytic Leukemia With Hodgkin and Reed-Sternberg (HRS) Cells: A Potential Diagnostic Pitfall in Lymph Node Biopsies.

Agrawal P1, Bal A, Das A, Sachdeva M, Prakash G.
Applied immunohistochemistry & molecular morphology : AIMM.Appl Immunohistochem Mol Morphol.2017 Jan;25(1):e9-e11.
Chronic lymphocytic leukemia (CLL) is known to undergo Richter transformation in a proportion of cases. Transformation into Hodgkin lymphoma has been described in a minority of the cases. However, CLL rarely also shows Hodgkin and Reed-Sternberg cells with a classic morphology and the immunophenotyp
PMID 26894648

Japanese Journal

A Case of Primary Nasopharyngeal Hodgkin Lymphoma

耳鼻咽喉科臨床　補冊 144(0), 98-99, 2015
NAID 130005110202

ホジキンリンパ腫の分子病理

臨床血液 56(10), 2024-2031, 2015
NAID 130005103296

慢性リンパ性白血病/小リンパ球性リンパ腫 (chronic lymphocytic leukemia/small lymphocytic lymphoma : CLL/SLL) 経過中に Hodgkin/Reed-Sternberg (HRS) 様細胞が出現した 1 例

日本臨床細胞学会雑誌 54(4), 270-274, 2015
NAID 130005098189

「Re」

　　[★]

「cell」

　　[★] 細胞　　　　　　　

[pmid19233470-1] Hartlapp I, Pallasch C, Weibert G, Kemkers A, Hummel M, Re D (February 2009). "Depsipeptide induces cell death in Hodgkin lymphoma-derived cell lines". Leuk. Res. 33 (7): 929–36. doi:10.1016/j.leukres.2008.12.013. PMID 19233470.

[2] Reed D. On the pathological changes in Hodgkin's disease, with special reference to its relation to tuberculosis. Johns Hopkins Hosp Rep 1902;10:133-96.

[3] Sternberg C. Uber eine eigenartige unter dem Bilde der Pseudoleukamie verlaufende Tuberculose des lymphatischen Apparates. Ztschr Heilk 1898;19:21–90.

[Robbins-4] Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.

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Reed-Sternberg cells