吻側延髄腹外側
- 関
- rostral ventrolateral medulla
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/21 06:59:40」(JST)
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Control of blood pressure is crucially dependent on the integrity of a small region of the brainstem called the ventrolateral medulla. Within this part of the brain are the cells that control the heart, blood vessels, swallowing, breathing and many other functions of the body that are not noticed at a conscious level; such unconscious activities are known as "'Autonomic'". One of these regions is the Rostral Ventrolateral Medulla (RVLM) is also known as the pressor area of the medulla (medulla pressor). It receives inhibitory GABAergic input from the caudal ventrolateral medulla (CVLM). The RVLM is the primary regulator of the sympathetic nervous system, sending excitatory fibers (catecholaminergic) to the sympathetic preganglionic neurons in the spinal cord, via reticulospinal tract.
The RVLM is notably involved in the baroreflex.
Physostigmine, a choline-esterase inhibitor, elevates endogenous levels of acetylcholine by stimulation of the RVLM.[1] Orexinergic neurons from the lateral hypothalamus output in the RVLM.
See also
References
- ^ Medullary pressor area: site of action of intravenous physostigmine
English Journal
- Exercise training restores oxidative stress and nitric oxide synthases in the rostral ventrolateral medulla of renovascular hypertensive rats.
- Sousa LE1,2,3, Magalhães WG1,3, Bezerra FS1,2,3, Santos RA4,3, Campagnole-Santos MJ4,3, Isoldi MC1,2,3, Alzamora AC1,2,3.
- Free radical research.Free Radic Res.2015 Nov;49(11):1335-43. doi: 10.3109/10715762.2015.1069291. Epub 2015 Aug 11.
- We hypothesize that exercise training (EX) reverses the level of nitric oxide (NO) and oxidative stress into rostral ventrolateral medulla (RVLM) of renovascular hypertensive rats (two kidneys, one clip - 2K1C). Microinjections of L-arginine (5 nmol), L-NAME (10 nmol), or saline (100 nl) were made i
- PMID 26140386
- Sex differences in NMDA GluN1 plasticity in rostral ventrolateral medulla neurons containing corticotropin-releasing factor type 1 receptor following slow-pressor angiotensin II hypertension.
- Van Kempen TA1, Dodos M2, Woods C2, Marques-Lopes J2, Justice NJ3, Iadecola C1, Pickel VM1, Glass MJ4, Milner TA5.
- Neuroscience.Neuroscience.2015 Oct 29;307:83-97. doi: 10.1016/j.neuroscience.2015.08.029. Epub 2015 Aug 22.
- There are profound, yet incompletely understood, sex differences in the neurogenic regulation of blood pressure. Both corticotropin signaling and glutamate receptor plasticity, which differ between males and females, are known to play important roles in the neural regulation of blood pressure. Howev
- PMID 26306872
- A pivotal role for enhanced brainstem Orexin receptor 1 signaling in the central cannabinoid receptor 1-mediated pressor response in conscious rats.
- Ibrahim BM1, Abdel-Rahman AA2.
- Brain research.Brain Res.2015 Oct 5;1622:51-63. doi: 10.1016/j.brainres.2015.06.011. Epub 2015 Jun 18.
- Orexin receptor 1 (OX1R) signaling is implicated in cannabinoid receptor 1 (CB1R) modulation of feeding. Further, our studies established the dependence of the central CB1R-mediated pressor response on neuronal nitric oxide synthase (nNOS) and extracellular signal-regulated kinase1/2 (ERK1/2) phosph
- PMID 26096126
Japanese Journal
- 『高血圧は脳の異常であり治療標的は脳である』 脳・腎臓・心臓・血管連関による血圧動的恒常性維持システム
- 岸 拓弥
- 日本薬理学雑誌 145(2), 54-58, 2015
- … 側野(rostral ventrolateral medulla:RVLM)に着目して研究を行っている.一連の研究により,圧受容器反射の中枢弓が血圧の変動・安定性維持に重要であり,さらには圧利尿においても圧と同等の作用を有することを明らかにした.さらに,バイオニックブレインによる人工圧受容器制御が極めて有効であることも示した.また,脳内においては,交感神経中枢である延髄RVLM内のアンジオテンシンⅡタイ …
- NAID 130004827717
- Aldosterone is synthesized in and activates bulbospinal neurons through mineralocorticoid receptors and ENaCs in the RVLM
- OSHIMA Naoki,ONIMARU Hiroshi,TAKECHI Hanako,YAMAMOTO Kojiro,WATANABE Atsushi,UCHIDA Takahiro,NISHIDA Yasuhiro,ODA Takashi,KUMAGAI Hiroo
- Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 36(6), 504-512, 2013-06-01
- NAID 10031189654
- 音のテンポと呼吸数の組み合わせが自律神経系に与える影響
- 渡辺謙,大石悠貴,柏野牧夫
- 研究報告音楽情報科学(MUS) 2013-MUS-99(57), 1-4, 2013-05-04
- … Mのテンポの音を聴く条件のみで、交感神経活動が増加し、平均心拍数の増加が見られた.他の条件では平均心拍数の変化は見られなかった.本研究から、交感神経活動の顕著な増加には、交感神経中枢であるRVLMの一定以上の発火率と、音と呼吸リズムの同期という二つの条件が必要な可能性が示唆された.結論として、音楽が生体の交感神経活動に影響を与えるには、音楽のテンポと呼吸数の組み合わせが重要な要因 …
- NAID 170000076681
Related Links
- 脳幹部の吻側延髄腹外側部(RVLM)に存在することが知られている循環中枢の研究にと… ... オルメサルタンがアルツハイマー型認知症の抑制に有用か (2008/ 6/20) 軽~中等度腎障害高血圧に対するARB長期投与の検討 (2008/ 6/20)
- 交感神経活動中枢の圧迫に起因する高血圧をシルニジピンが抑制 2009/10/ 7 頭側延髄腹外側野(RVLM)は交感神経活動の制御中枢であり、血管運動中枢とも呼ばれる領域である。RVLMの周辺動脈による圧迫が認められる症例が ...
- 細見記念シンポジウム 3 高血圧患者の発症初期には末梢交感神経の電気活動は、正常者と比較して亢進している。末梢交感神経の亢進は、RVLM の機能亢進およびCVLM の機能低下によって起こる。後 述するように、当教室の松浦ら[7 ...
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★リンクテーブル★
[★]
- 英
- rostral ventrolateral medulla、RVLM
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吻側延髄腹外側
- 関
- RVLM
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