関: phosphotyrosine phosphatase、protein tyrosine phosphatase、PTP、tyrosine phosphatase

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English Journal

Fullerene derivatives as a new class of inhibitors of protein tyrosine phosphatases.

Kobzar OL1, Trush VV1, Tanchuk VY1, Zhilenkov AV2, Troshin PA2, Vovk AI3.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2014 Jul 15;24(14):3175-9. doi: 10.1016/j.bmcl.2014.04.110. Epub 2014 May 5.
In this study, we identified water-soluble C60 and C70 fullerene derivatives as a novel class of protein tyrosine phosphatase inhibitors. The evaluated compounds were found to inhibit CD45, PTP1B, TC-PTP, SHP2, and PTPβ with IC50 values in the low micromolar to high nanomolar range. These results d
PMID 24856066

Tritrichomonas foetus: Characterisation of ecto-phosphatase activities in the endoflagelar form and their possible participation on the parasite's transformation and cytotoxicity.

Pereira-Neves A1, Rosales-Encina JL2, Meyer-Fernandes JR3, Benchimol M4.
Experimental parasitology.Exp Parasitol.2014 Jul;142:67-82. doi: 10.1016/j.exppara.2014.04.007. Epub 2014 Apr 30.
The protist parasite Tritrichomonas foetus displays a pear-shaped (PS) and a pseudocystic or endoflagellar form (EFF). Here, we characterised the ecto-phosphatase activity on the surface of EFF and compare its biochemical properties to that of the PS regarding rate of substrate hydrolysis, pH activa
PMID 24793018

The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinoma.

Rothe A1, Jachimowicz RD, Borchmann S, Madlener M, Keßler J, Reiners KS, Sauer M, Hansen HP, Ullrich RT, Chatterjee S, Borchmann P, Yazaki P, Koslowsky TC, Engert A, Heukamp LC, Hallek M, von Strandmann EP.
International journal of cancer. Journal international du cancer.Int J Cancer.2014 Jun 15;134(12):2829-40. doi: 10.1002/ijc.28609. Epub 2013 Nov 29.
NKG2D, an activating receptor expressed on NK cells and T cells, is critically involved in tumor immunosurveillance. In this study, we explored the potential therapeutic utility of the NKG2D ligand ULBP2 for the treatment of colon carcinoma. To this end we designed a fusion protein consisting of hum
PMID 24242212

秋山孝洋,佐俣哲郎,村山洋,アキヤマタカヒロ,サマタテツロウ,ムラヤマオオシ,Takahiro Akiyama,Tetsurou Samata,Ohoshi Murayama
麻布大学雑誌 = Journal of Azabu University 15/16, 282-283, 2007
… Lar encodes a membrane protein containing immunoglobulin-like domains, fibronectin type III repeats and PTPase domains. …
NAID 120005345264

秋山孝洋,佐俣哲郎,村山洋
麻布大学雑誌 15/16, 282-283, 2007
ショウジョウバエ卵巣は,多細胞生物の器官構築の過程を研究するための良いモデルシステムとなっている。我々の研究室で単離した卵巣形態に異常の生じる突然変異体のうち,主にLar変異体について間接蛍光抗体法で解析した。共焦点レーザー顕微鏡の観察から,Lar変異体では,卵巣小菅が個々に分解せず,Larはショウジョウバエの卵巣において接着班の分解を介してASCsの移動に関与し,蛹の卵巣を卵巣小管に分離する過程 …
NAID 110006977962

Tungstate-Induced Color-Pattern Modifications of Butterfly Wings are Independent of Stress Response and Ecdysteroid Effect(Animal Diversity and Evolution)

Otaki Joji M.,Ogasawara Tsuyoshi,Yamamoto Haruhiko
Zoological science 22(6), 635-644, 2005-06-25
… Systemic injections of sodium tungstate, a protein-tyrosine phosphatase (PTPase) inhibitor, to pupae immediately after pupation have been shown to efficiently produce characteristic color-pattern modifications on the wings of many species of butterflies. … This conclusion that suggests that the putative PTPase signaling pathway that is sensitive to tungstate uniquely contributes to the wing-wide color-pattern development in butterflies. …
NAID 110006281837