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Cefdinir is a third generation oral cephalosporin antibiotic. It was discovered by Fujisawa Pharmaceutical Co., Ltd. "Fujisawa" (now Astellas) and introduced in 1991 under the brand name Cefzon.^[1]^[2] Warner-Lambert licensed this cephalosporin, cefdinir, for marketing in US from Fujisawa, Japan.^[3] Abbott obtained U.S. marketing rights to Omnicef (Cefdinir) in December 1998 through an agreement with Warner-Lambert Company.^[4] It was approved by FDA on Dec 4, 1997.^[5] It is available in US as Omnicef by Abbott Laboratories and in India as Cednir by Abbott and Cefdiel by Ranbaxy.

As of 2008, cefdinir was the highest-selling cephalosporin antibiotic in the United States, with more than US$585 million in retail sales of its generic versions alone.^[6]

Mechanism of action

Main article: Cephalosporin

Indications

Therapeutic uses of cefdinir include otitis media, soft tissue infections, and respiratory tract infections, including sinusitis, strep throat, community-acquired pneumonia and acute exacerbations of bronchitis.

Susceptible organisms

Cefdinir is a bacteriocidal antibiotic. It can be used to treat infections caused by several Gram-negative and Gram-positive bacteria.

Side effects

Side effects include diarrhea, vaginal infections or inflammation, nausea, headache, and abdominal pain."^[7]

Available forms

Cefdinir is administered orally. It is available as capsules and a suspension. Dosage, schedule, and duration of therapy varies according to the type of infection.

"Blood" in the stool

The pediatric version of cefdinir can bind to iron in the digestive tract; in rare cases, this causes a rust or red discoloration of the stool. Blood typically appears dark brown or black in stool, and testing may confirm which is present.

If the reddish stool is accompanied by abdominal pain, weight loss, diarrhea, etc., a Clostridium difficile infection caused by the antibiotic could be signified.

References

^ http://www.astellas.com/en/corporate/news/detail/astellas-filed-lawsuit-against.html
^ http://wenku.baidu.com/view/a2ef6330b90d6c85ec3ac6fa.html
^ http://www.elsevierbi.com/publications/the-pink-sheet/52/005/comprecin-has-excellent-chance-to-reach-us-market-this-year-dupont-prophenytoin-crosslicense-deal?p=1
^ http://www.globenewswire.com/newsarchive/mrx/pages/news_releases.html?d=94045
^ http://www.drugs.com/mtm/cefdinir.html
^ "2008 Top 200 generic drugs by retail dollars" PDF (399.4 KB). Drug Topics (May 26, 2009). Retrieved on July 24, 2009.
^ "Omnicef capsules Patient Information". Abbott Laboratories. February 2004. Archived from the original on 2006-11-18. http://web.archive.org/web/20061118132152/http://www.rxabbott.com/pdf/omnicef_capsules_patient_friendly.pdf. Retrieved 2006-11-24.

External links

Medline Plus: Cefdinir

UpToDate Contents

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1. 成人における急性副鼻腔炎および鼻副鼻腔炎：治療 acute sinusitis and rhinosinusitis in adults treatment
2. 小児における急性中耳炎：治療 acute otitis media in children treatment
3. 成人における急性中耳炎（化膿性および漿液性） acute otitis media in adults suppurative and serous
4. 乳児および1ヶ月以上の小児における尿路感染症の急性期マネージメント、画像検査、
および予後 acute management imaging and prognosis of urinary tract infections in infants and children older than one month
5. 小児における市中肺炎の外来治療 outpatient treatment of community acquired pneumonia in children

English Journal

Optimizing the spectrofluorimetric determination of cefdinir through a Taguchi experimental design approach.

Abou-Taleb NH1, El-Wasseef DR1, El-Sherbiny DT1, El-Ashry SM1.
Luminescence : the journal of biological and chemical luminescence.Luminescence.2015 Oct 12. doi: 10.1002/bio.3042. [Epub ahead of print]
The aim of this work is to optimize a spectrofluorimetric method for the determination of cefdinir (CFN) using the Taguchi method. The proposed method is based on the oxidative coupling reaction of CFN and cerium(IV) sulfate. The quenching effect of CFN on the fluorescence of the produced cerous ion
PMID 26456088

[Analysis of the interaction between cefdinir and bovine serum albumin by spectrometry].

Liu L1, Cheng F2.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.Zhong Nan Da Xue Xue Bao Yi Xue Ban.2015 Sep 28;40(9):979-86. doi: 10.11817/j.issn.1672-7347.2015.09.006.
in

English, Chinese目的：研究头孢地尼(cefdinir，CE)与牛血清白蛋白(bovine serum albumin，BSA)之间的相互作用。方法：在优化的实验条件下，运用荧光光谱和紫外-可见光谱法研究CE与BSA之间的相互作用。结果：CE可与BSA形成基态复合物�

PMID 26408617

Cephalosporin use in penicillin-allergic patients: a survey of otolaryngologists and literature review.

Persky MJ1, Roof SA1, Fang Y2,3, Jethanamest D1, April MM1.
The Laryngoscope.Laryngoscope.2015 Aug;125(8):1822-6. doi: 10.1002/lary.25227. Epub 2015 Mar 5.
OBJECTIVES/HYPOTHESIS: This study investigated the differences between the standard guidelines and the practice patterns of otolaryngologists in managing "penicillin-allergic" patients. A major goal was to identify factors influencing an otolaryngologist's choice of antibiotic.STUDY DESIGN: Cross-se
PMID 25752938

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★リンクテーブル★

リンク元

「セフジニル」

Cefdinir
Systematic (IUPAC) name
	8-[2-(2-amino-1,3-thiazol-4-yl)-1-hydroxy-2-nitroso-; ethenyl]amino-4-ethenyl-7-oxo-2-thia-6-; azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
Clinical data
Trade names	Cefzon
AHFS/Drugs.com	monograph
MedlinePlus	a698001
Pregnancy cat.	B (US)
Legal status	Rx only (US)
Routes	Oral
Pharmacokinetic data
Bioavailability	16% to 21% (dose-dependent)
Protein binding	60% to 70%
Metabolism	Negligible
Half-life	1.7 ± 0.6 hours
Excretion	Renal
Identifiers
CAS number	91832-40-5
ATC code	J01DD15
PubChem	CID 6915944
DrugBank	DB00535
ChemSpider	5291705
UNII	CI0FAO63WC
KEGG	D00917
ChEBI	CHEBI:3485
ChEMBL	CHEMBL927
Chemical data
Formula	C14H13N5O5S2
Mol. mass	395.416 g/mol
	SMILES O=C2N1/C(=C(/C=C)CS[C@@H]1[C@@H]2NC(=O)C(=N\O)/c3nc(sc3)N)C(=O)O;
	InChI InChI=1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1 ; Key:RTXOFQZKPXMALH-GHXIOONMSA-N ;
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　　[★]

英: cefdinir
商: セフゾン, Omnicef、セフニール

第3世代セフェム系抗菌薬
経口抗菌薬
7位に2-アミノチアゾリルヒドロキシイミノ基を有する構造

内服後約4時間で最高血中濃度に達し、半減期約1.7時間で主として尿中に排泄される。

各種β-ラクタマーゼに安定
特にグラム陽性菌に対する抗菌力を増したことで、グラム陰性菌・陽性菌にバランスのとれた抗菌力を示す。

[1] ttp://www.astellas.com/en/corporate/news/detail/astellas-filed-lawsuit-against.html

[2] ttp://wenku.baidu.com/view/a2ef6330b90d6c85ec3ac6fa.html

[3] ttp://www.elsevierbi.com/publications/the-pink-sheet/52/005/comprecin-has-excellent-chance-to-reach-us-market-this-year-dupont-prophenytoin-crosslicense-deal?p=1

[4] ttp://www.globenewswire.com/newsarchive/mrx/pages/news_releases.html?d=94045

[5] ttp://www.drugs.com/mtm/cefdinir.html

[6] "2008 Top 200 generic drugs by retail dollars" PDF (399.4 KB). Drug Topics (May 26, 2009). Retrieved on July 24, 2009.

[7] "Omnicef capsules Patient Information". Abbott Laboratories. February 2004. Archived from the original on 2006-11-18. http://web.archive.org/web/20061118132152/http://www.rxabbott.com/pdf/omnicef_capsules_patient_friendly.pdf. Retrieved 2006-11-24.

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案内

案内

Omnicef