O-アセチル-ADP-リボース

WordNet

the 15th letter of the Roman alphabet (同)o
the blood group whose red cells carry neither the A nor B antigens; "people with type O blood are universal donors" (同)type_O, group O
the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
a pentose sugar important as a component of ribonucleic acid
in the Christian era; used before dates after the supposed year Christ was born; "in AD 200" (同)A.D., anno_Domini
the organic group of acetic acid (CH3CO-) (同)acetyl_group, acetyl radical, ethanoyl group, ethanoyl radical

PrepTutorEJDIC

《呼び掛けの名前の前につけて》『おお』,あ / (驚き・恐れ・喜び・苦痛などを表して)『おお』,ああ,まあ / 《肯定・否定を強めて》
oxygenの化学記号
ohmオーム / Old
answer / ampere
リボース(リボ核酸の加水分解によって得られる五炭糖)

UpToDate Contents

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1. 糖尿病性多発性神経障害の病因および予防 pathogenesis and prevention of diabetic polyneuropathy
2. HER2陽性転移性乳癌の全身治療 systemic treatment for her2 positive metastatic breast cancer
3. 漿液性の卵巣癌、卵管癌、および腹膜癌の病因 pathogenesis of ovarian fallopian tubal and peritoneal serous carcinomas
4. 乳癌における脳転移のマネージメント management of brain metastases in breast cancer
5. 糖尿病性神経障害の治療 treatment of diabetic neuropathy

English Journal

SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation.

Pazienza V, Borghesan M, Mazza T, Sheedfar F, Panebianco C, Williams R, Mazzoccoli G, Andriulli A, Nakanishi T, Vinciguerra M.Author information Department of Medical Sciences, Gastroenterology Unit, IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.AbstractNon-alcoholic-fatty-liver-disease (NAFLD) encompasses conditions associated to fat deposition in the liver, which are generally deteriorated during the aging process. MacroH2A1, a variant of histone H2A, is a key transcriptional regulator involved in tumorigenic processes and cell senescence, and featuring two alternatively splicing isoforms, macroH2A1.1 and macroH2A1.2. MacroH2A1.1 binds with high affinity O-acetyl ADP ribose, a small metabolite produced by the reaction catalysed by NAD+-dependent deacetylase SIRT1, whereas macroH2A1.2 is unable to do so. The functional significance of this binding is unknown. We previously reported that the hepatic levels of macroH2A1.1 and macroH2A1.2 are differentially expressed in mice models of NAFLD. Here we show that over-expression of macroH2A1.1, but not of macroH2A1.2, is able to protect hepatocytes against lipid accumulation. MacroH2A1.1 over-expressing cells display ameliorated glucose metabolism, reduced expression of lipidogenic genes and fatty acids content. SIRT1/macroH2A1.1-dependent epigenetic regulation of lipid metabolism may be relevant to NAFLD development.
Aging.Aging (Albany NY).2014 Jan 28. [Epub ahead of print]
Non-alcoholic-fatty-liver-disease (NAFLD) encompasses conditions associated to fat deposition in the liver, which are generally deteriorated during the aging process. MacroH2A1, a variant of histone H2A, is a key transcriptional regulator involved in tumorigenic processes and cell senescence, and fe
PMID 24473773

SIR-nucleosome interactions: structure-function relationships in yeast silent chromatin.

Oppikofer M, Kueng S, Gasser SM.Author information Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.AbstractDiscrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression, referred to as heterochromatin or "silent" chromatin. Constitutively silent chromatin is found in subtelomeric domains in a number of species, ranging from yeast to man. In addition, chromatin-dependent repression of mating type loci occurs in both budding and fission yeasts, to enable sexual reproduction. The silencing of chromatin in budding yeast is characterized by an assembly of Silent Information Regulatory (SIR) proteins-Sir2, Sir3 and Sir4-with unmodified nucleosomes. Silencing requires the lysine deacetylase activity of Sir2, extensive contacts between Sir3 and the nucleosome, as well as interactions among the SIR proteins, to generate the Sir2-3-4 or SIR complex. Results from recent structural and reconstitution studies suggest an updated model for the ordered assembly and organization of SIR-dependent silent chromatin in yeast. Moreover, studies of subtelomeric gene expression reveal the importance of subtelomeric silent chromatin in the regulation of genes other than the silent mating type loci. This review covers recent advances in this field.
Gene.Gene.2013 Sep 15;527(1):10-25. doi: 10.1016/j.gene.2013.05.088. Epub 2013 Jun 18.
Discrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression, referred to as heterochromatin or "silent" chromatin. Constitutively silent chromatin is found in subtelomeric domains in a number of species, ranging from yeast to man. In additio
PMID 23791651

Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose.

Dvorakova M, Nencka R, Dejmek M, Zbornikova E, Brezinova A, Pribylova M, Pohl R, Migaud ME, Vanek T.Author information Institute of Experimental Botany, Academy of Sciences of Czech Republic, v.v.i., Rozvojova 263, Prague 6, 165 02, Czech Republic.AbstractThe non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.
Organic & biomolecular chemistry.Org Biomol Chem.2013 Sep 14;11(34):5702-13. doi: 10.1039/c3ob41016a.
The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.
PMID 23884430

Japanese Journal

Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta-NAD+dependent histone/protein deacetylases

JACKSON M D
J Biol Chem 277, 18535-18544, 2002
NAID 80015347997

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