WordNet

select carefully from a group; "She finally picked her successor"; "He picked his way carefully"
remove in small bits; "pick meat from a bone"
a heavy iron tool with a wooden handle and a curved head that is pointed on both ends; "they used picks and sledges to break the rocks" (同)pickax, pickaxe
a small thin device (of metal or plastic or ivory) used to pluck a stringed instrument (同)plectrum, plectron
a basketball maneuver; obstructing an opponent with ones body; "he was called for setting an illegal pick"
a thin sharp implement used for removing unwanted material; "he used a pick to clean the dirt out of the cracks"
attack with or as if with a pickaxe of ice or rocky ground, for example; "Pick open the ice" (同)break_up
look for and gather; "pick mushrooms"; "pick flowers" (同)pluck, cull
pilfer or rob; "pick pockets"
provoke; "pick a fight or a quarrel"
small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre

PrepTutorEJDIC

(入念に)…‘を'『選ぶ』,選び取る / 〈草花・果実など〉‘を'『摘む』,もぐ / 〈鳥など〉‘の'羽をむしる;(…から)…‘を'むしる《+『名』+『from』+『名』》 / (とがった物で)…‘を'つつく,つついて穴をあける《+『名』+『with』+『名』》 / 〈鳥などが〉〈えさ〉‘を'つつく,つついて食べる / 〈争いなど〉‘を'しかける;(人に)〈口論など〉‘を'ふっかける《+『名』+『with』+『名』〈人〉》 / (針金などで)〈錠〉‘を'こじあける / 〈ポケット・さいふなど〉‘の'中身をすり取る / 〈弦楽器・弦〉‘を'指で鳴らす,つまびく / 入念に選ぶ / 〈鳥が〉えさをつつく;(食浴がなくて)〈人が〉(…を)少しずつ食べる《+『at』+『名』》 / 〈U〉(…の)選択(choice),(…を)選ぶこと(権利)《+『of』+『名』》 / 〈C〉(…から)選択された人(物);《the~》(…から)選ばれた最上の人(物)《+『of』+『名』》
《複合語を作って》「ほじる(つつく)道具」の意を表す / 《話》=plectrum
(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞

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A marked paucity of granule cells in the developing cerebellum of the Npc1(-/-) mouse is corrected by a single injection of hydroxypropyl-β-cyclodextrin.

Nusca S1, Canterini S1, Palladino G1, Bruno F1, Mangia F1, Erickson RP2, Fiorenza MT3.
Neurobiology of disease.Neurobiol Dis.2014 Oct;70:117-26. doi: 10.1016/j.nbd.2014.06.012. Epub 2014 Jun 24.
In this study we show that postnatal development of cerebellar granule neurons (GNs) is defective in Npc1(-/-) mice. Compared to age-matched wild-type littermates, there is an accelerated disappearance of the external granule layer (EGL) in these mice. This is due to a premature exit from the cell c
PMID 24969023

Combination-targeting to multiple endothelial cell adhesion molecules modulates binding, endocytosis, and in vivo biodistribution of drug nanocarriers and their therapeutic cargoes.

Papademetriou I1, Tsinas Z1, Hsu J1, Muro S2.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2014 Aug 28;188:87-98. doi: 10.1016/j.jconrel.2014.06.008. Epub 2014 Jun 14.
Designing of drug nanocarriers to aid delivery of therapeutics is an expanding field that can improve medical treatments. Nanocarriers are often functionalized with elements that recognize cell-surface molecules involved in subcellular transport to improve targeting and endocytosis of therapeutics.
PMID 24933603

A novel mouse model of a patient mucolipidosis II mutation recapitulates disease pathology.

Paton L1, Bitoun E1, Kenyon J1, Priestman DA1, Oliver PL1, Edwards B1, Platt FM1, Davies KE2.
The Journal of biological chemistry.J Biol Chem.2014 Aug 8. pii: jbc.M114.586156. [Epub ahead of print]
Mucolipidosis II (MLII) is a lysosomal storage disorder caused by loss of N-acetylglucosamine-1-phosphotransferase which tags lysosomal enzymes with a mannose 6-phosphate marker for transport to the lysosome. In MLII the loss of this marker leads to deficiency of multiple enzymes and non-enzymatic p
PMID 25107912