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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/03/30 03:23:44」(JST)
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NFATC1 |
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Available structures |
PDB |
Ortholog search: PDBe RCSB |
List of PDB id codes |
1A66, 1NFA
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Identifiers |
Aliases |
NFATC1, NF-ATC, NFAT2, NFATc, NF-ATc1.2, nuclear factor of activated T-cells 1 |
External IDs |
MGI: 102469 HomoloGene: 32336 GeneCards: NFATC1 |
Gene ontology |
Molecular function |
• RNA polymerase II distal enhancer sequence-specific DNA binding
• DNA binding
• RNA polymerase II regulatory region sequence-specific DNA binding
• RNA polymerase II transcription factor binding
• transcription factor activity, sequence-specific DNA binding
• mitogen-activated protein kinase p38 binding
• FK506 binding
• transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
• protein binding
• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
• RNA polymerase II transcription coactivator binding
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Cellular component |
• cytoplasm
• cytosol
• nuclear chromatin
• nucleus
• nucleoplasm
• nuclear body
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Biological process |
• intracellular signal transduction
• regulation of transcription, DNA-templated
• calcineurin-NFAT signaling cascade
• transcription from RNA polymerase II promoter
• transcription, DNA-templated
• positive regulation of transcription, DNA-templated
• Fc-epsilon receptor signaling pathway
• positive regulation of transcription from RNA polymerase II promoter
• Wnt signaling pathway, calcium modulating pathway
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Sources:Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
NM_172390
NM_001278669
NM_001278670
NM_001278672
NM_001278673
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NM_001278675
NM_006162
NM_172387
NM_172388
NM_172389
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NM_001164109
NM_001164110
NM_001164111
NM_001164112
NM_016791
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NM_198429
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RefSeq (protein) |
NP_001265598
NP_001265599
NP_001265601
NP_001265602
NP_001265604
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NP_006153
NP_765975
NP_765976
NP_765977
NP_765978
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Location (UCSC) |
Chr 18: 79.4 – 79.53 Mb |
Chr 18: 80.61 – 80.71 Mb |
PubMed search |
[1] |
[2] |
Wikidata |
View/Edit Human |
View/Edit Mouse |
Nuclear factor of activated T-cells, cytoplasmic 1 is a protein that in humans is encoded by the NFATC1 gene.[3]
Contents
- 1 Function
- 2 Interactions
- 3 See also
- 4 References
- 5 Further reading
- 6 External links
Function
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as ciclosporin. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.[4]
Interactions
NFATC1 has been shown to interact with PIM1.[5]
See also
References
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Northrop JP, Ho SN, Chen L, Thomas DJ, Timmerman LA, Nolan GP, Admon A, Crabtree GR (Jun 1994). "NF-AT components define a family of transcription factors targeted in T-cell activation". Nature. 369 (6480): 497–502. doi:10.1038/369497a0. PMID 8202141.
- ^ "Entrez Gene: NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1".
- ^ Rainio EM, Sandholm J, Koskinen PJ (Feb 2002). "Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase". Journal of Immunology. 168 (4): 1524–7. doi:10.4049/jimmunol.168.4.1524. PMID 11823475.
Further reading
- Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annual Review of Immunology. 15: 707–47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.
- Crabtree GR (Mar 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): 611–4. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876.
- Horsley V, Pavlath GK (Mar 2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". The Journal of Cell Biology. 156 (5): 771–4. doi:10.1083/jcb.200111073. PMC 2173310. PMID 11877454.
- Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M (Apr 2004). "HIV/SIV escape from immune surveillance: focus on Nef". Current HIV Research. 2 (2): 141–51. doi:10.2174/1570162043484924. PMID 15078178.
- Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree GR, Francke U (1995). "Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp". Cytogenetics and Cell Genetics. 68 (3-4): 185–91. doi:10.1159/000133910. PMID 7842733.
- Jabado N, Le Deist F, Fisher A, Hivroz C (Nov 1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology. 24 (11): 2646–52. doi:10.1002/eji.1830241112. PMID 7957556.
- Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A (Nov 1994). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochemical and Biophysical Research Communications. 205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID 7999066.
- Park J, Takeuchi A, Sharma S (Aug 1996). "Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc". The Journal of Biological Chemistry. 271 (34): 20914–21. doi:10.1074/jbc.271.34.20914. PMID 8702849.
- Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT (Sep 1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". European Journal of Immunology. 26 (9): 2181–8. doi:10.1002/eji.1830260933. PMID 8814265.
- Beals CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR (Mar 1997). "Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3". Science. 275 (5308): 1930–4. doi:10.1126/science.275.5308.1930. PMID 9072970.
- Kinoshita S, Su L, Amano M, Timmerman LA, Kaneshima H, Nolan GP (Mar 1997). "The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells". Immunity. 6 (3): 235–44. doi:10.1016/S1074-7613(00)80326-X. PMID 9075924.
- Zhou P, Sun LJ, Dötsch V, Wagner G, Verdine GL (Mar 1998). "Solution structure of the core NFATC1/DNA complex". Cell. 92 (5): 687–96. doi:10.1016/S0092-8674(00)81136-8. PMID 9506523.
- Kinoshita S, Chen BK, Kaneshima H, Nolan GP (Nov 1998). "Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells". Cell. 95 (5): 595–604. doi:10.1016/S0092-8674(00)81630-X. PMID 9845362.
- Chuvpilo S, Zimmer M, Kerstan A, Glöckner J, Avots A, Escher C, Fischer C, Inashkina I, Jankevics E, Berberich-Siebelt F, Schmitt E, Serfling E (Feb 1999). "Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells". Immunity. 10 (2): 261–9. doi:10.1016/S1074-7613(00)80026-6. PMID 10072078.
- Chuvpilo S, Avots A, Berberich-Siebelt F, Glöckner J, Fischer C, Kerstan A, Escher C, Inashkina I, Hlubek F, Jankevics E, Brabletz T, Serfling E (Jun 1999). "Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes". Journal of Immunology. 162 (12): 7294–301. PMID 10358178.
- Wang JK, Kiyokawa E, Verdin E, Trono D (Jan 2000). "The Nef protein of HIV-1 associates with rafts and primes T cells for activation". Proceedings of the National Academy of Sciences of the United States of America. 97 (1): 394–9. doi:10.1073/pnas.97.1.394. PMC 26674. PMID 10618429.
- Porter CM, Havens MA, Clipstone NA (Feb 2000). "Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization". The Journal of Biological Chemistry. 275 (5): 3543–51. doi:10.1074/jbc.275.5.3543. PMID 10652349.
External links
- NFATC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
PDB gallery
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1a66: SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES
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1nfa: HUMAN TRANSCRIPTION FACTOR NFATC DNA BINDING DOMAIN, NMR, 10 STRUCTURES
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
English Journal
- Osmolar regulation of endothelin-1 production by the inner medullary collecting duct.
- Pandit MM1, Gao Y2, van Hoek A2, Kohan DE3.
- Life sciences.Life Sci.2015 Nov 9. pii: S0024-3205(15)30063-1. doi: 10.1016/j.lfs.2015.10.037. [Epub ahead of print]
- AIMS: Endothelin-1 (ET-1) is an autocrine inhibitor of collecting duct (CD) Na+ and water reabsorption. CD ET-1 production is increased by a high salt diet and is important in promoting a natriuretic response. The mechanisms by which a high salt diet enhances CD ET-1 are being uncovered. In particul
- PMID 26546722
- Calcineurin Inhibitors Downregulate HNF-1β and May Affect the Outcome of HNF1B Patients After Renal Transplantation.
- Faguer S1, Esposito L, Casemayou A, Pirson Y, Decramer S, Cartery C, Hazzan M, Garrigue V, Roussey G, Cointault O, Ho T, Merville P, Devuyst O, Gourdy P, Chassaing N, Bascands JL, Kamar N, Schanstra JP, Rostaing L, Chauveau D.
- Transplantation.Transplantation.2015 Nov 9. [Epub ahead of print]
- BACKGROUND: Patients with HNF1B mutations develop progressive chronic renal failure, diabetes mellitus (40-50%), and liver tests abnormalities (40-70%). In HNF1B patients who reach end-stage renal disease, single kidney transplantation (SKT) or combined kidney-pancreas transplantation can be conside
- PMID 26555949
- GATA2 is required for lymphatic vessel valve development and maintenance.
- Kazenwadel J, Betterman KL, Chong CE, Stokes PH, Lee YK, Secker GA, Agalarov Y, Demir CS, Lawrence DM, Sutton DL, Tabruyn SP, Miura N, Salminen M, Petrova TV, Matthews JM, Hahn CN, Scott HS, Harvey NL.
- The Journal of clinical investigation.J Clin Invest.2015 Aug 3;125(8):2979-94. doi: 10.1172/JCI78888. Epub 2015 Jul 27.
- Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including Emberger syndrome, a disorder characterized by lymphedema and predisposition to myelodysplastic syndrome/acute myeloid leukemia (MDS/AML). Desp
- PMID 26214525
Japanese Journal
- 関節リウマチ薬物治療 これだけは知っておきたい ブシラミンが処方される理由(第1回)ブシラミンはなぜ効くか[含 出題]
- 免疫系と破骨細胞 (特集 骨を壊して骨を作る--細胞レベルの制御から3Dデザインへ)
Related Links
- 2005.06.24 NFATcと転写因子osterixは骨形成にかかわる 東京医科歯科大学の高柳先生と共同ですすめています骨形成にかかわる転写制御の解析(当方はトランスクリプトーム解析を行っています)がNature Medicineにアクセプトされました。
- 2 数多くのCn の基質が定されていて、次のセクションで詳細が 示されている。しかし、数多く の基質がある中でCnの主要な基質は、転写因子NFAT(nuclear factor of activated T cells)である。NFAT(正式にはNFATc)ファミリーはいくつか ...
Related Pictures
★リンクテーブル★
[★]
- 英
- NFATc transcription factor
[★]
- 英
- nuclear factor of activated T cells, NF-AT
- 関
- NFAT family、カルシニューリン、シクロスポリンA、FK506
- 普段は細胞質にあってセリン/スレオニンキナーゼにより核移行配列がリン酸化されており核移行が妨げられている。
- 細胞質の[Ca2+]↑によりカルモジュリンがCa2+を結合しコンフォメーションが変化する。
- Ca2+を結合したカルモジュリンは、セリン/スレオニンホスファターゼであるカルシニューリンに結合する。
- カルモジュリンとの結合によりカルシニューリンは活性化され、NFATを脱リン酸化する。
- 脱リン酸化されたNFATは核に移行し遺伝子発現を行う。
- T細胞ではIL-2の転写に関わっている