N6-メチルアデニン
WordNet
- the 14th letter of the Roman alphabet (同)n
PrepTutorEJDIC
- nitrogenの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2018/07/25 20:56:42」(JST)
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Site-specific DNA-methyltransferase (adenine-specific) |
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Identifiers |
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EC number |
2.1.1.72 |
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CAS number |
69553-52-2 |
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Databases |
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IntEnz |
IntEnz view |
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BRENDA |
BRENDA entry |
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ExPASy |
NiceZyme view |
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KEGG |
KEGG entry |
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MetaCyc |
metabolic pathway |
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PRIAM |
profile |
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PDB structures |
RCSB PDB PDBe PDBsum |
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Search |
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PMC |
articles |
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PubMed |
articles |
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NCBI |
proteins |
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Site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72, modification methylase, restriction-modification system) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + DNA adenine S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
This is a large group of enzymes.[4]
See also
References
- ^ Kessler, C.; Manta, V. (1990). "Specificity of restriction endonucleases and DNA modification methyltransferases: a review". Gene. 92: 1–248. doi:10.1016/0378-1119(90)90486-B. PMID 2172084.
- ^ Roberts, R.J. (1990). "Restriction enzymes and their isoschizomers". Nucleic Acids Res. 18: 2331–2365. doi:10.1093/nar/18.suppl.2331. PMC 331877 . PMID 2159140.
- ^ Yuan, R. (1981). "Structure and mechanism of multifunctional restriction endonucleases". Annu. Rev. Biochem. 50: 285–319. doi:10.1146/annurev.bi.50.070181.001441. PMID 6267988.
- ^ R.J. Roberts. "A complete listing of all of these enzymes".
External links
- Site-specific+DNA-methyltransferase+(adenine-specific) at the US National Library of Medicine Medical Subject Headings (MeSH)
Transferase: one carbon transferases (EC 2.1) |
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2.1.1: Methyl- | N- |
- Histamine N-methyltransferase
- Phenylethanolamine N-methyltransferase
- Amine N-methyltransferase
- Phosphatidylethanolamine N-methyltransferase
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O- |
- 5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase
- Catechol-O-methyl transferase
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Homocysteine |
- Betaine-homocysteine methyltransferase
- Homocysteine methyltransferase
- Methionine synthase
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Other |
- Phosphatidyl ethanolamine methyltransferase
- DNMT3B
- Histone methyltransferase
- Thymidylate synthase
- DNA methyltransferase
- Thiopurine methyltransferase
- Cyclopropane-fatty-acyl-phospholipid synthase
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2.1.2: Hydroxymethyl-, Formyl- and Related | Hydroxymethyltransferase |
- Serine hydroxymethyltransferase
- 3-methyl-2-oxobutanoate hydroxymethyltransferase
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Formyltransferase |
- Phosphoribosylglycinamide formyltransferase
- Inosine monophosphate synthase
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Other |
- Glutamate formimidoyltransferase
- Aminomethyltransferase
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2.1.3: Carboxy- and Carbamoyl | Carboxy |
- methylmalonyl-CoA carboxytransferase
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Carbamoyl |
- Aspartate carbamoyltransferase
- Ornithine carbamoyltransferase
- Oxamate carbamoyltransferase
- Putrescine carbamoyltransferase
- 3-hydroxymethylcephem carbamoyltransferase
- Lysine carbamoyltransferase
- N-acetylornithine carbamoyltransferase
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2.1.4: Amidine |
- Arginine:glycine amidinotransferase
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Enzymes |
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Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
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Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
- Enzyme activator
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Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
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English Journal
- N6 -methyladenine functions as a potential epigenetic mark in eukaryotes.
- Sun Q1, Huang S2,3, Wang X2, Zhu Y2, Chen Z2, Chen D2.
- BioEssays : news and reviews in molecular, cellular and developmental biology.Bioessays.2015 Aug 21. doi: 10.1002/bies.201500076. [Epub ahead of print]
- N6 -methyladenine (6mA) is one of the most abundant types of DNA methylation, and plays an important role in bacteria; however, its roles in higher eukaryotes, such as plants, insects, and mammals, have been considered less important. Recent studies highlight that 6mA does indeed occur, and that it
- PMID 26293475
- NanoCluster Beacons Enable Detection of a Single N6-Methyladenine.
- Chen YA1, Obliosca JM1, Liu YL1, Liu C1, Gwozdz ML1, Yeh HC1.
- Journal of the American Chemical Society.J Am Chem Soc.2015 Aug 14. [Epub ahead of print]
- While N6-methyladenine (m6A) is a common modification in prokaryotic and lower eukaryotic genomes and has many biological functions, there is no simple and cost-effective way to identify a single N6-methyladenine in a nucleic acid target. Here we introduce a robust, simple, enzyme-free and hybridiza
- PMID 26261877
- N6 -Methyladenine: A Potential Epigenetic Mark in Eukaryotic Genomes.
- Summerer D1.
- Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2015 Jul 17. doi: 10.1002/anie.201504594. [Epub ahead of print]
- N6 -methyladenine (6mA) is known to be an epigenetic mark in bacterial genomes. Three studies have now demonstrated the existence of significant levels of 6mA in the genomes of several phylogenetically distinct eukaryotes, along with findings that suggest that 6mA may act as a dynamic epigenetic mar
- PMID 26211457
Japanese Journal
- Effect of Methylated Adenine in Plasmid DNA on Transgene Expression in Mice(Biopharmacy)
- Ochiai Hiroshi,Harashima Hideyoshi,Kamiya Hiroyuki
- Biological & pharmaceutical bulletin 28(10), 2019-2022, 2005-10-01
- … Recently, we found that plasmid DNA containing N^6-methyladenine (N^6MeA), a bacterium-specific modified base, induced cytokine twice as efficiently as plasmid DNA without N^6MeA, when complexed with cationic lipids. …
- NAID 110003666388
- Purines. LV. Syntheses and cytokinin activities of some adenine and adenosine derivatives related to 1'-methylzeatin
- 藤井 澄三,大場 正志,河村 仁,羽石 剛,松原 聰
- Chemical & pharmaceutical bulletin 41(8), 1362-1365, 1993-08-15
- … A similar condensation of 16 with methylamine yielded 2-hydroxy-N6- methyladenine (7). …
- NAID 110003630623
- The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces.
- YEBRA MARIA JESUS,SANCHEZ JESUS,MARTIN CRISTINA G.,HARDISSON CARLOS,BARBES COVADONGA
- The Journal of Antibiotics 44(10), 1141-1147, 1991
- … All the methylated bases found in Streptomyces RNA (1-methyladenine, N6-methyladenine, N6, N6-dimethyladenine and 7-methylguanine) are inhibited by this antibiotic. …
- NAID 130003501926
Related Pictures
★リンクテーブル★
[★]
- 英
- N6-methyladenine, m6A
- 関
- メチルアデニン
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N6-メチルアデニン N6-methyladenine
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