WordNet
- the 14th letter of the Roman alphabet (同)n
PrepTutorEJDIC
- nitrogenの化学記号
- neodymiumの化学記号
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English Journal
- Systematic N-methylation of oxytocin: Impact on pharmacology and intramolecular hydrogen bonding network.
- Sciabola S1, Goetz GH2, Bai G2, Rogers BN1, Gray DL1, Duplantier A1, Fonseca KR3, Vanase-Frawley MA2, Kablaoui NM4.
- Bioorganic & medicinal chemistry.Bioorg Med Chem.2016 Aug 15;24(16):3513-20. doi: 10.1016/j.bmc.2016.05.062. Epub 2016 May 31.
- Oxytocin (OT) is a peptide hormone agonist of the OT receptor (OTR) that plays an important role in social behaviors such as pair bonding, maternal bonding and trust. The pharmaceutical development of OT as an oral peptide therapeutic has been hindered historically by its unfavorable physicochemical
- PMID 27297999
- N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
- Warrier T1, Kapilashrami K2, Argyrou A3, Ioerger TR4, Little D1, Murphy KC5, Nandakumar M1, Park S1, Gold B1, Mi J1, Zhang T1, Meiler E6, Rees M3, Somersan-Karakaya S7, Porras-De Francisco E6, Martinez-Hoyos M6, Burns-Huang K1, Roberts J1, Ling Y1, Rhee KY8, Mendoza-Losana A6, Luo M9, Nathan CF10.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2016 Aug 2;113(31):E4523-30. doi: 10.1073/pnas.1606590113. Epub 2016 Jul 18.
- The rising incidence of antimicrobial resistance (AMR) makes it imperative to understand the underlying mechanisms. Mycobacterium tuberculosis (Mtb) is the single leading cause of death from a bacterial pathogen and estimated to be the leading cause of death from AMR. A pyrido-benzimidazole, 14, was
- PMID 27432954
Japanese Journal
- The Extinction Coefficient of N-Methylated Aβ30–40 Depends on the Position of N-Methylation
- , ,
- Chemistry Letters 44(1), 35-37, 2015
- … The molar extinction coefficient at 210 nm (ε210) of the N-methylated analogs of Aβ30–40 was analyzed. … Additive contributions from a 10-residue peptide main chain (ε210CONH) and modulation caused by N-methylation (Δε210) accounted for the observed results. … The difference in the Δε210 value was explained in terms of changes in electronic structure and conformational restriction resulting from N-methylation. …
- NAID 130004868295
- Synthesis of IB-01212 by multiple N-methylations of peptide bonds.
- Nabika Ryota,Oishi Shinya,Misu Ryosuke,Ohno Hiroaki,Fujii Nobutaka
- Bioorganic & medicinal chemistry 22(21), 6156-6162, 2014-09-08
- … There are many natural peptides with multiple N-methylamino acids that exhibit potent attractive biological activities. … N-methylation of a peptide bond(s) is also one of the standard approaches in medicinal chemistry of bioactive peptides, to improve the potency and physicochemical properties, especially membrane permeability. …
- NAID 120005512275
Related Pictures
★リンクテーブル★
[★]
- 関
- number of experiment、sample size
- pの前の[n]はmと記載する。synptom→symptom
[★]
- 関
- methylate
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ネオジム neodymium