- 同
- NAT-2
WordNet
- the 14th letter of the Roman alphabet (同)n
PrepTutorEJDIC
- nitrogenの化学記号
- neodymiumの化学記号
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/02/24 22:19:31」(JST)
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N-acetyltransferase 2 (arylamine N-acetyltransferase) |
PDB rendering based on 2pfr. |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
2PFR
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Identifiers |
Symbols |
NAT2; AAC2; NAT-2; PNAT |
External IDs |
OMIM: 612182 MGI: 97279 HomoloGene: 115468 ChEMBL: 2194 GeneCards: NAT2 Gene |
EC number |
2.3.1.5 |
Gene Ontology |
Molecular function |
• arylamine N-acetyltransferase activity
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Cellular component |
• cytosol
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Biological process |
• xenobiotic metabolic process
• small molecule metabolic process
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
10 |
17960 |
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Ensembl |
ENSG00000156006 |
ENSMUSG00000025588 |
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UniProt |
P11245 |
P50294 |
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RefSeq (mRNA) |
NM_000015 |
NM_008673 |
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RefSeq (protein) |
NP_000006 |
NP_032699 |
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Location (UCSC) |
Chr 8:
18.25 – 18.26 Mb |
Chr 8:
67.49 – 67.49 Mb |
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PubMed search |
[1] |
[2] |
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N-acetyltransferase 2 (arylamine N-acetyltransferase), also known as NAT2, is an enzyme which in humans is encoded by the NAT2 gene.[1]
Contents
- 1 Function
- 2 Phenotype prediction
- 3 References
- 4 Further reading
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Function
This gene encodes a type of N-acetyltransferase. The NAT2 isozyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near NAT2.[2]
Phenotype prediction
The NAT2 acetylator phenotype can be inferred from NAT2 genotype (a combination of SNPs observed in a given individual).[3][4]
References
- ^ Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV (February 1995). "Nomenclature for N-acetyltransferases". Pharmacogenetics 5 (1): 1–17. doi:10.1097/00008571-199502000-00001. PMID 7773298.
- ^ "Entrez Gene: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10.
- ^ "NAT2PRED: a computational predictor of the human N-AcetylTransferase-2 (NAT2) acetylator phenotype". State University of New York – Albany. http://nat2pred.rit.albany.edu/. Retrieved 2009-04-30.
- ^ Kuznetsov IB, McDuffie M, Moslehi R (May 2009). "A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype". Bioinformatics (Oxford, England) 25 (9): 1185–6. doi:10.1093/bioinformatics/btp121. PMC 2672629. PMID 19261719. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2672629/.
Further reading
- Vatsis KP, Weber WW, Bell DA, et al. (1995). "Nomenclature for N-acetyltransferases.". Pharmacogenetics 5 (1): 1–17. doi:10.1097/00008571-199502000-00001. PMID 7773298.
- Windmill KF, McKinnon RA, Zhu X, et al. (1997). "The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies.". Mutat. Res. 376 (1-2): 153–60. doi:10.1016/S0027-5107(97)00038-9. PMID 9202751.
- Lan Q, Rothman N, Chow WH, et al. (2003). "No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer.". Cancer Epidemiol. Biomarkers Prev. 12 (4): 384–6. PMID 12692115.
- Ochs-Balcom HM, Wiesner G, Elston RC (2007). "A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.". Am. J. Epidemiol. 166 (3): 246–54. doi:10.1093/aje/kwm066. PMID 17535831.
- Sanderson S, Salanti G, Higgins J (2007). "Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.". Am. J. Epidemiol. 166 (7): 741–51. doi:10.1093/aje/kwm167. PMID 17675654.
PDB gallery
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2pfr: Human N-acetyltransferase 2
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UpToDate Contents
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English Journal
- Enantioselective N-acetylation of 2-phenylglycine by an unusual N-acetyltransferase from Chryseobacterium sp.
- Takenaka S, Honma Y, Yoshida K, Yoshida K.SourceDepartment of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai Nada-ku, Kobe, 657-8501, Japan, hakko3@kobe-u.ac.jp.
- Biotechnology letters.Biotechnol Lett.2013 Jul;35(7):1053-9. doi: 10.1007/s10529-013-1172-z. Epub 2013 Mar 12.
- The demand for D-2-phenylglycine used to synthesize semisynthetic antibiotics and pesticides is increasing. We have isolated a Chryseobacterium sp. that selectively transformed the L-form of racemic D,L-2-phenylglycine to (2S)-2-acetylamide-2-phenylacetic acid with a molar yield of 50 % and an enan
- PMID 23479412
- Rapid and intermediate N-acetylators are less susceptible to oxidative damage among 4,4'-methylenebis(2-chloroaniline) (MBOCA)-exposed workers.
- Lin IS, Fan PL, Chen HI, Loh CH, Shih TS, Liou SH.SourceDepartment of Family Medicine & Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Neihu, Taipei, Taiwan, ROC.
- International journal of hygiene and environmental health.Int J Hyg Environ Health.2013 Jul;216(4):515-20. doi: 10.1016/j.ijheh.2013.02.001. Epub 2013 Mar 13.
- OBJECTIVES: In this study, we explored the association between a marker of oxidative stress, 8-hydroxydeoxyguanosine (8-OHdG), and genetic polymorphism of the carcinogen-metabolizing enzyme N-acetyltransferase 2 (NAT2) among 4,4'-methylenebis(2-chloroaniline) (MBOCA)-exposed workers.METHODS: The stu
- PMID 23491024
- Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations.
- Hewitt NJ, Edwards RJ, Fritsche E, Goebel C, Aeby P, Scheel J, Reisinger K, Ouédraogo G, Duche D, Eilstein J, Latil A, Kenny J, Moore C, Kuehnl J, Barroso J, Fautz R, Pfuhler S.Source* SWS, 64390 Erzhausen, Germany;
- Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2013 Jun;133(2):209-17. doi: 10.1093/toxsci/kft080. Epub 2013 Mar 28.
- Several human skin models employing primary cells and immortalized cell lines used as monocultures or combined to produce reconstituted 3D skin constructs have been developed. Furthermore, these models have been included in European genotoxicity and sensitization/irritation assay validation projects
- PMID 23539547
Japanese Journal
- 酵母に見いだした新規な抗酸化酵素「N-アセチルトランスフェラーゼMpr1」
- 高木 博史,那須野 亮
- 化学と生物 : 日本農芸化学会会誌 : 生命・食・環境 53(3), 148-155, 2015-03
- NAID 40020383483
- 1P-061 Chryseobacterium sp. 5-3B由来N-アセチルトランスフェラーゼの特製解析(酵素学,酵素工学,一般講演)
- N-acetyltransferase (nat) Is a Critical Conjunct of Photoperiodism between the Circadian System and Endocrine Axis in Antheraea pernyi
- Ahmed A. M. Mohamed,Wang Qiushi,Bembenek Jadwiga,Ichihara Naoyuki,Hiragaki Susumu,Suzuki Takeshi,Takeda Makio
- PLoS ONE 9(3), e92680, 2014-05
- NAID 120005465538
Related Links
- 1. Abe, M., Suzuki, T., Deguchi, T. An improved method for genotyping of N-acetyltransferase polymorphism by polymerase chain reaction. Jpn. J. Hum. Genet. 38: 163-168, 1993. [PubMed: 8102908, related citations ...
- This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which ...
★リンクテーブル★
[★]
- 英
- nucleic acid amplification test, NAT
-NAT
- 関
- N-acetyltransferase 2
[★]
核酸増幅試験
- 同
- nonaccidental trauma
- 関
- N-acetyltransferase 2
[★]
アセチルトランスフェラーゼ、アセチル基転移酵素、アセチル化酵素
- 関
- transacetylase
[★]
- 関
- number of experiment、sample size
- pの前の[n]はmと記載する。synptom→symptom
[★]
[★]
ネオジム neodymium