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- the 14th letter of the Roman alphabet (同)n
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- nitrogenの化学記号
- neodymiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/19 09:46:13」(JST)
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N-Acetylglutamic acid |
|
IUPAC name
2-Acetamidopentanedioic acid[1]
|
Other names
Acetylglutamic acid[citation needed]
|
Identifiers |
Abbreviations |
- N-Acetyl-Glu[citation needed]
- NAcGlu[citation needed]
- Ac-Glu-OH[citation needed]
|
CAS number |
5817-08-3 Y, 19146-55-5 R Y, 1188-37-0 S Y |
PubChem |
185, 1560015 R, 70914 S |
ChemSpider |
180 Y, 1272049 R Y, 64077 S Y |
EC number |
227-388-6 |
DrugBank |
DB04075 |
KEGG |
C00624 Y |
MeSH |
N-acetylglutamate |
ChEBI |
CHEBI:17533 Y |
RTECS number |
LZ9725000 S |
Beilstein Reference |
1727473 S |
3DMet |
B00147 |
Jmol-3D images |
Image 1
Image 2 |
-
Cc(:[o]):[nH]C(CCc(:[o]):[oH])c([OH]):[o]
CC(=O)NC(CCC(O)=O)C(O)=O
|
-
InChI=1S/C7H11NO5/c1-4(9)8-5(7(12)13)2-3-6(10)11/h5H,2-3H2,1H3,(H,8,9)(H,10,11)(H,12,13) Y
Key: RFMMMVDNIPUKGG-UHFFFAOYSA-N Y
|
Properties |
Molecular formula |
C7H11NO5 |
Molar mass |
189.17 g mol−1 |
Appearance |
White cystals |
Density |
1 g mL−1 |
Melting point |
191-194 °C, 464-467 K, 376-381 °F
|
Solubility in water |
36 g L−1 |
Hazards |
LD50 |
>7 g kg−1 (oral, rat) |
Related compounds |
Related alkanoic acids |
- N-Acetylaspartic acid
- Aceglutamide
- Citrulline
- Pivagabine
|
Related compounds |
|
Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
Infobox references |
N-Acetylglutamic acid (abbreviated NAcGlu) is biosynthesized from glutamic acid and acetyl-CoA by the enzyme N-acetylglutamate synthase. Arginine is the activator for this reaction.
The reverse reaction, hydrolysis of the acetyl group, is catalyzed by a specific hydrolase.
NAcGlu activates carbamoyl phosphate synthetase in the urea cycle.
See also[edit]
References[edit]
- ^ "N-Acetyl-DL-glutamic acid - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification. Retrieved 25 June 2012.
External links[edit]
UpToDate Contents
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English Journal
- The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate.
- Renga B, Mencarelli A, Cipriani S, D'Amore C, Zampella A, Monti MC, Distrutti E, Fiorucci S.SourceDipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Perugia, Italy. barbara.renga@unipg.it
- Biochimica et biophysica acta.Biochim Biophys Acta.2011 Nov;1812(11):1522-31. Epub 2011 Jul 1.
- Hepatic transport and metabolism of glutamate and glutamine are regulated by intervention of several proteins. Glutamine is taken up by periportal hepatocytes and is the major source of ammonia for urea synthesis and glutamate for N-acetylglutamate (NAG) synthesis, which is catalyzed by the N-acetyl
- PMID 21757002
Japanese Journal
- Effect of the Quality of Dietary Amino Acids Composition on the Urea Synthesis in Rats
- Tujioka Kazuyo,Ohsumi Miho,Hayase Kazutoshi [他],YOKOGOSHI Hidehiko
- Journal of nutritional science and vitaminology 57(1), 48-55, 2011-02-01
- … The urinary excretion of urea, the liver concentration of N-acetylglutamate, and the liver concentration of free serine, glutamic acids and alanine were greater in the group given the amino acid mix diet of lower quality. … These results suggest that the increased concentrations of amino acids and N-acetylglutamate seen in the liver of rats given the amino acid mix diets of lower quality are likely among the factors stimulating urea synthesis. …
- NAID 10028106110
- Changes in N-Acetylglutamate Are Involved in Regulating Urea Synthesis in Rats Given a Low Gluten Diet Supplemented with L-Lysine, L-Methinone and L-Threonine
- Tujioka Kazuyo,Tuchiya Tamami,Shi Xianglan [他],OHSUMI Miho,HAYASE Kazutoshi,YOKOGOSHI Hidehiko
- Journal of nutritional science and vitaminology 55(5), 417-422, 2009-10-01
- … The purpose of present study was to determine whether the addition of dietary limiting amino acids to a low gluten diet affected the synthesis and degradation of N-acetylglutamate and regulated urea synthesis. … The urinary excretion of urea, and the liver concentration of N-acetylglutamate, and the liver activity of N-acetylglutamate synthetase decreased with the addition of dietary L-lysine, L-threonine and L-methionine. …
- NAID 10025972140
Related Links
- Normal enzyme function of N-acetylglutamate synthetase (NAGS) deficiency is confined to the hepatic mitochondria and mediates the reaction acetyl-coenzyme A (CoA) + glutamate → N-acetylglutamate + CoA. As a mitochondrial reaction, each of the substrates is normally omnipresent. Acetyl-CoA is a cofactor in many ...
- N-acetylglutamate synthase deficiency is an inherited disorder that causes ammonia to accumulate in the blood. Ammonia, which is formed when proteins are broken down in the body, is toxic if the levels become too ...
Related Pictures
★リンクテーブル★
[★]
- 英
- N-acetylglutamate, NAG
[★]
N-アセチルグルタミン酸合成酵素欠損症
[★]
- 関
- number of experiment、sample size
- pの前の[n]はmと記載する。synptom→symptom
[★]
[★]
ネオジム neodymium