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the 14th letter of the Roman alphabet (同)n

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nitrogenの化学記号
neodymiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/02/27 12:24:33」(JST)

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N-Acetylgalactosamine (GalNAc), is an amino sugar derivative of galactose.

Function

In humans it is the terminal carbohydrate forming the antigen of blood group A.^[1]

It is typically the first monosaccharide that connects serine or threonine in particular forms of protein O-glycosylation.

N-Acetylgalactosamine is necessary for intercellular communication, and is concentrated in sensory nerve structures of both humans and animals.

GalNAc is also used as a targeting ligand in investigational antisense oligonucleotides and siRNA therapies targeted to the liver, where it binds to the asialoglycoprotein receptors on hepatocytes. ^[2]

References

^ Donald M. Marcus; Elvin A. Kabat; Gerald Schiffman (1964). "Immunochemical Studies on Blood Groups. XXXI. Destruction of Blood Group A Activity by an Enzyme from Clostridium tertium Which Deacetylates N-Acetylgalactosamine in Intact Blood Group Substances". Biochemistry. 3: 437–443. doi:10.1021/bi00891a023.
^ http://pubs.acs.org/doi/abs/10.1021/ja505986a

English Journal

Biochemical studies on carbohydrates. 145. N-acetylchondrosamine, n-acetyl-, -methylchondrosaminide and desaminochondrosin-cinchonidine-salt.

MASAMUNE H, MAKI M, HIYAMA N.
The Tohoku journal of experimental medicine.Tohoku J Exp Med.1951 Oct 25;54(4):313-7.
PMID 14913509

Japanese Journal

Biochemical Studies on Carbohydrates:CXLV. N-Acetylchondrosamine, N-Acetyl-α-methylchondrosaminide and Desaminochondrosin-cinchonidine-salt

正宗一,眞木正博,檜山登
The Tohoku Journal of Experimental Medicine 54(4), 313-317, 1951
NAID 130003408344

「N-アセチルガラクトサミン」

N-Acetylgalactosamine
Names
	IUPAC name 2-(Acetylamino)-2-deoxy-D-galactose
	Other names GalNAc; 2-Acetamido-2-deoxy-D-galactose; N-Acetylchondrosamine; 2-Acetamido-2-deoxy-D-galactopyranose; N-Acetyl-D-galactosamine
Identifiers
CAS Number	1811-31-0 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:40356 ;
ChemSpider	76020 ;
PubChem CID	84265;
	InChI InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8+/m1/s1 Key: OVRNDRQMDRJTHS-CBQIKETKSA-N ; InChI=1/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8+/m1/s1 Key: OVRNDRQMDRJTHS-CBQIKETKBW ;
	SMILES O[C@@H](C(CO)O[C@H](O)[C@H]1NC(C)=O)[C@H]1O ;
Properties
Chemical formula	C8H15NO6
Molar mass	221.21 g/mol
Melting point	172 to 173 °C (342 to 343 °F; 445 to 446 K)
Hazards
S-phrases (outdated)	S24/25
Related compounds
Related monosaccharides	N-Acetylglucosamine; Galactosamine; Galactose
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references