関: MT1 melatonin receptor

WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
the 13th letter of the Roman alphabet (同)m

PrepTutorEJDIC

=sense organ / 受信装置
Mach number / mark[s] / Monsieur
Montana

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/21 20:28:37」(JST)

wiki en

[Wiki en表示]

Melatonin receptor type 1A is a protein that in humans is encoded by the MTNR1A gene.^[1]^[2]

Function

This gene encodes the MT₁ protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.^[2]

Ligands

Melatonin – full agonist
Afobazole – agonist

References

^ Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM (May 1995). "Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)". Genomics 27 (2): 355–7. doi:10.1006/geno.1995.1056. PMID 7558006.
^ ^a ^b "Entrez Gene: MTNR1A melatonin receptor 1A".

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. インスリン受容体の構造および機能 structure and function of the insulin receptor
2. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患 cd3 t cell receptor complex disorders causing immunodeficiency
3. T細胞受容体の遺伝学 t cell receptor genetics
4. T細胞受容体シグナル伝達 t cell receptor signaling
5. 乳癌予防のための選択的エストロゲン受容体調節因子およびアロマターゼ阻害剤 selective estrogen receptor modulators and aromatase inhibitors for breast cancer prevention

English Journal

Gender-related invasion differences associated with mRNA expression levels of melatonin membrane receptors in colorectal cancer.

León J, Casado J, Carazo A, Sanjuán L, Maté A, Muñoz de Rueda P, de la Cueva P, Quiles R, Ruíz S, Ruíz-Extremera A, Salmerón J.SourceSan Cecilio University Hospital, Granada, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.
Molecular carcinogenesis.Mol Carcinog.2012 Aug;51(8):608-18. doi: 10.1002/mc.20832. Epub 2011 Aug 1.
Melatonin inhibits growth and invasive capacity of colon cancer cells in vitro through its membrane (MT1 and MT2) and/or nuclear receptors (RORα). Previous studies showed that this indoleamine is present in both the normal and colon cancer at similar levels. Therefore, we analyzed MT1, MT2, and ROR
PMID 21809392

The antidepressant agomelatine inhibits stress-mediated changes in amino acid efflux in the rat hippocampus and amygdala.

Reagan LP, Reznikov LR, Evans AN, Gabriel C, Mocaër E, Fadel JR.SourceDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Rd, Columbia, SC 29208, USA.
Brain research.Brain Res.2012 Jul 23;1466:91-8. Epub 2012 May 27.
Agomelatine is a potent melatonergic (MT1 and MT2) receptor agonist and 5HT(2C) antagonist that is an effective antidepressant in animal models of depression and in patients suffering from depression. Our recent studies revealed that acute restraint stress increases extracellular levels of glutamate
PMID 22647752

Japanese Journal

ラメルテオンの基礎研究 (特集ラメルテオンの基礎と臨床)

平井圭介
精神科 17(6), 624-631, 2010-12
NAID 40017419327

メラトニン受容体作動薬ラメルテオン(ロゼレム^【○!R】錠8mg)の薬理作用と臨床試験成績

平井圭介,加藤浩紀,西川久夫,行弘信仁,西山啓次,宮本政臣
日本薬理学雑誌 136(1), 51-60, 2010-07-01
… ，筋弛緩作用，前向性健忘，反跳性不眠，依存性などの種々の有害作用を惹起する．これに対してラメルテオン（Ramelteon，TAK-375，商品名Rozerem®）は，主に視床下部視交叉上核に存在するメラトニン受容体（MT1/MT2受容体）にアゴニストとして作用してcAMP産生系を抑制し，サルおよびネコで強力な睡眠誘発作用を示した．その睡眠パターンは自然睡眠に極めて近いものであった．また，既存薬で見られる学習記憶障害 …
NAID 10026544589

「MT1 melatonin receptor」

Melatonin receptor 1A
Identifiers
Symbols	MTNR1A ; MEL-1A-R; MT1
External IDs	OMIM: 600665 MGI: 102967 HomoloGene: 21207 IUPHAR: 287 ChEMBL: 1945 GeneCards: MTNR1A Gene
Gene ontology
Molecular function	• protein binding; • melatonin receptor activity; • hormone binding; • organic cyclic compound binding;
Cellular component	• plasma membrane; • integral component of plasma membrane; • receptor complex;
Biological process	• G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • mating behavior; • circadian rhythm; • positive regulation of cGMP biosynthetic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;