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the 13th letter of the Roman alphabet (同)m
the imperial dynasty of China from 1368 to 1644 (同)Ming dynasty
a form of address for a woman (同)Ms.

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Mach number / mark[s] / Monsieur
(中国の)明,明朝(1368‐1644)
mendeleviumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/13 17:20:28」(JST)

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Introduction

Mycoplasma hyopneumoniae is a species of bacteria known to cause the disease Porcine Enzootic Pneumonia, a highly contagious and chronic disease affecting pigs (Whittlestone, 1979). As with other mollicutes, M. hyopneumoniae is small in size (400 - 1200 nm), has a small genome (893 - 920 kilo-base pairs (kb)) and lacks a cell wall (Tajima et al., 1982). It is considered to be difficult to grow in laboratories due to its complex nutritional requirements and the high chances of contamination associated with mycoplasma culture. To successfully grow the bacterium, an environment of 5-10% carbon dioxide is required, and the medium should demonstrate an acid colour shift.

This bacterium is a concern in the livestock industry as it causes a significant reduction in the growing weight of pigs. Losses in the U.S.A. have been previously estimated at 200 million to 1 billion dollars per annum (Clark et al., 1991). Porcine enzootic pneumonia is endemic worldwide and M. hyopneumoniae is present in almost every pig herd (Minion, 2002). Treatment of this disease is limited to antibiotics, which are currently ineffective as they do not completely remove the infection. Vaccines have been found to reduce the severity of the disease but do not prevent the disease from occurring in infected pigs (Haesebrouck, et al., 2004).

Pathogenesis

M. hyopneumoniae has been found to attach to the cilia of epithelial cells in the lungs of swine. They cause cilia to stop beating (ciliostasis), clumping and loss of cilia, eventually leading to epithelial cell death; which is the source of the lesions found in the lungs of pigs with porcine enzootic pneumonia. This damage impedes normal ciliary clearance and often secondary infections develop. On a cellular level, mononuclear infiltration of peribronchiolar and perivascular areas occurs.

Sadly, the immune response caused by the presence of M. hyopneumoniae in pigs is slow and ineffective (Minion, 2002); it is also believed to cause much of the damage that is seen in pigs with the disease. This mycoplasma is not known to produce any specifically harmful toxin like many other disease-causing bacteria, but some mildly toxic by-products have been observed (Geary et al., 1985).

Conclusions

Mycoplasma hyopneumoniae has been a topic of interest in the scientific community due to the economic impact of porcine enzootic pneumonia. Three separate strains (232, J & 7448) of this mycoplasma have had their genomes sequenced, making it the most sequenced mycoplasma (Minion et al., 2004; Vasconcelos et al., 2005). Research has been mainly focused on identifying adhesins with a final goal of developing an effective vaccine that prevents M. hyopneumoniae from attaching to lung cilia.

References

Clark, L. K., C. H. Armstrong, M. J. Freeman, A. B. Scheidt, L. Sands-Freeman, and K. Knox. 1991. Investigating the transmission of Mycoplasma hyopneumoniae in a swine herd with enzootic pneumonia. Veterinary Medicine 86:543-550.
Geary, S. J., and E. M. Walczak. 1985. Isolation of a Cytopathic Factor from Mycoplasma-Hyopneumoniae. Infection and Immunity 48:576-578.
Haesebrouck, F., F. Pasmans, K. Chiers, D. Maes, R. Ducatelle, and A. Decostere. 2004. Efficacy of vaccines against bacterial diseases in swine: what can we expect? Vet Microbiol 100:255-68.
Maré, C. J. and W. P. Switzer 1965. Vet Med Small Anim Clin 60:841-846
Minion, F. C. 2002. Molecular pathogenesis of mycoplasma animal respiratory pathogens. Frontiers in Bioscience 7:d1410-1422.
Minion, F. C., E. J. Lefkowitz, M. L. Madsen, B. J. Cleary, S. M. Swartzell, and G. G. Mahairas. 2004. The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis. J Bacteriol 186:7123-33.
Tajima, M., and T. Yagihashi. 1982. Interaction of Mycoplasma-Hyopneumoniae with the Porcine Respiratory Epithelium as Observed by Electron-Microscopy. Infection and Immunity 37:1162-1169.
Vasconcelos, A. T., H. B. Ferreira, C. V. Bizarro, S. L. Bonatto, M. O. Carvalho, P. M. Pinto, D. F. Almeida, L. G. Almeida, R. Almeida, L. Alves-Filho, E. N. Assuncao, V. A. Azevedo, M. R. Bogo, M. M. Brigido, M. Brocchi, H. A. Burity, A. A. Camargo, S. S. Camargo, M. S. Carepo, D. M. Carraro, J. C. de Mattos Cascardo, L. A. Castro, G. Cavalcanti, G. Chemale, R. G. Collevatti, C. W. Cunha, B. Dallagiovanna, B. P. Dambros, O. A. Dellagostin, C. Falcao, F. Fantinatti-Garboggini, M. S. Felipe, L. Fiorentin, G. R. Franco, N. S. Freitas, D. Frias, T. B. Grangeiro, E. C. Grisard, C. T. Guimaraes, M. Hungria, S. N. Jardim, M. A. Krieger, J. P. Laurino, L. F. Lima, M. I. Lopes, E. L. Loreto, H. M. Madeira, G. P. Manfio, A. Q. Maranhao, C. T. Martinkovics, S. R. Medeiros, M. A. Moreira, M. Neiva, C. E. Ramalho-Neto, M. F. Nicolas, S. C. Oliveira, R. F. Paixao, F. O. Pedrosa, S. D. Pena, M. Pereira, L. Pereira-Ferrari, I. Piffer, L. S. Pinto, D. P. Potrich, A. C. Salim, F. R. Santos, R. Schmitt, M. P. Schneider, A. Schrank, I. S. Schrank, A. F. Schuck, H. N. Seuanez, D. W. Silva, R. Silva, S. C. Silva, C. M. Soares, K. R. Souza, R. C. Souza, C. C. Staats, M. B. Steffens, S. M. Teixeira, T. P. Urmenyi, M. H. Vainstein, L. W. Zuccherato, A. J. Simpson, and A. Zaha. 2005. Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae. J Bacteriol 187:5568-77.
Whittlestone, P. 1979. Porcine Mycoplasmas, p. 133-166. In J. G. Tully and R. F. Whitcomb (ed.), The Mycoplasmas, vol. II. Academic Press, Inc., New York.
Mycoplasma hyopneumoniae, expert reviewed and published by Wikivet at http://en.wikivet.net/Mycoplasma_hyopneumoniae, accessed 13/09/2011

English Journal

In vitro activity of tylvalosin against Spanish field strains of Mycoplasma hyopneumoniae.

Tavío MM1, Poveda C2, Assunção P2, Ramírez AS2, Poveda JB2.
The Veterinary record.Vet Rec.2014 Nov 29;175(21):539. doi: 10.1136/vr.102458. Epub 2014 Sep 2.
Mycoplasma hyopneumoniae is involved in the porcine enzootic pneumonia and respiratory disease complex; therefore, the search for new treatment options that contribute to the control of this organism is relevant. The minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations of
PMID 25185108

Antibody responses of swine following infection with Mycoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae and M. flocculare.

Neto JC1, Strait EL1, Raymond M1, Ramirez A1, Minion FC2.
Veterinary microbiology.Vet Microbiol.2014 Nov 7;174(1-2):163-71. doi: 10.1016/j.vetmic.2014.08.008. Epub 2014 Aug 20.
Several mycoplasma species possessing a range of virulence have been described in swine. The most commonly described are Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, Mycoplasma hyosynoviae, and Mycoplasma flocculare. They are ubiquitious in many pig producing areas of the world, and except for M.
PMID 25240775

Molecular epidemiology of Mycoplasma hyopneumoniae from outbreaks of enzootic pneumonia in domestic pig and the role of wild boar.

Kuhnert P1, Overesch G2.
Veterinary microbiology.Vet Microbiol.2014 Nov 7;174(1-2):261-6. doi: 10.1016/j.vetmic.2014.08.022. Epub 2014 Sep 3.
Mycoplasma hyopneumoniae is the major cause of enzootic pneumonia (EP) in domestic pigs, a disease with low mortality but high morbidity, having a great economic impact for producers. In Switzerland EP has been successfully eradicated, however, sporadic outbreaks are observed with no obvious source.
PMID 25236987

Japanese Journal

Immunology : Comparison of immune responses to intranasal and intrapulmonary vaccinations with the attenuated Mycoplasma hyopneumoniae 168 strain in pigs

The journal of veterinary medical science 77(5), 519-525, 2015-05
NAID 40020489416

Comparison of immune responses to intranasal and intrapulmonary vaccinations with the attenuated Mycoplasma hyopneumoniae 168 strain in pigs

Journal of Veterinary Medical Science 77(5), 519-525, 2015
NAID 130005071891

Comparison of immune responses to intranasal and intrapulmonary vaccination with the attenuated Mycoplasma hyopneumoniae 168 strain in pigs

Journal of Veterinary Medical Science advpub(0), 2015
NAID 130004781083

「Mycoplasma hyopneumoniae」

Mycoplasma hyopneumonaie
Scientific classification
Kingdom:	Bacteria
Division:	Firmicutes
Class:	Mollicutes
Order:	Mycoplasmatales
Family:	Mycoplasmataceae
Genus:	Mycoplasma
Species:	M. hyopneumoniae
Binomial name
	Mycoplasma hyopneumoniae; Maré and Switzer, 1965