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Mycobacterium haemophilum is a species of the phylum Actinobacteria (Gram-positive bacteria with high guanine and cytosine content, one of the dominant phyla of all bacteria), belonging to the genus Mycobacterium.
Contents
1Description
2Pathogenesis
3Type strain
4Notes
5References
6External links
Description
Short, occasionally curved, gram-positive, nonmotile and strongly acid-fast rods.
Colony characteristics
Nonpigmented and rough to smooth colonies.
Physiology
Media have to be supplemented with 0.4% haemoglobin or 60 μM hemin (factor X) or 15 mg/ml ferric ammonium citrate respectively, but not with FeCl3 or catalase.
Slow growth on Löwenstein-Jensen media or Middlebrook 7H10 agar at 32 °C within 2–4 weeks.
Growth slower at 25 °C and 35 °C and absent at 37 °C.
Strictly intracellular growth in tissue cultures of fibroblasts.
Differential characteristics
Unique among mycobacteria in its requirement for hemin or ferric ammonium citrate for growth.
Distribution.
Pathogenesis
Infects patients with suppressed immune systems.[1]
Clinical presentation: multiple skin nodules occurring in clusters or without definitive pattern, commonly involving the extremities. Abscesses, draining fistulas and osteomyelitis may be associated with the nodules. Paediatric patients with localised cervical lymphadenopathy.
Biosafety level 2
Type strain
First isolated in Israel from a subcutaneous granuloma from a patient with Hodgkin's disease. An environmental reservoir is presumed.
Strain ATCC 29548 = CCUG 47452 = CIP 105049 = DSM 44634 = NCTC 11185.
Notes
^Mycobacterium Haemophilum at eMedicine
References
Sompolinsky, D.; Lagziel, A.; Naveh, D.; Yankilevitz, T. (1978). "Mycobacterium haemophilum sp. nov., a New Pathogen of Humans". International Journal of Systematic Bacteriology. 28 (1): 67–75. doi:10.1099/00207713-28-1-67.
External links
Type strain of Mycobacterium haemophilum at BacDive - the Bacterial Diversity Metadatabase
Development of Quantitative Real-Time PCR Assays for Postmortem Detection of Mycobacterium spp. Common in Zebrafish (Danio rerio) Research Colonies.
Meritet DM, Mulrooney DM, Kent ML, Löhr CV.
Journal of the American Association for Laboratory Animal Science : JAALAS.J Am Assoc Lab Anim Sci.2017 Feb 9. [Epub ahead of print]
Mycobacterium spp. infections are common in zebrafish kept in research facilities. These comorbidities can substantiallymodulate the responses of these fish to external and internal stimuli. Therefore, diagnostic tests to detect Mycobacterium spp.infections in zebrafish colonies prove essential. Her
Successful management of Mycobacterium haemophilum lower extremity cutaneous infection in a matched-unrelated donor stem cell transplant recipient.
Baluch A1, Pasikhova Y2, Snyder M3.
Transplant infectious disease : an official journal of the Transplantation Society.Transpl Infect Dis.2017 Feb;19(1). doi: 10.1111/tid.12627. Epub 2016 Dec 16.
Mycobacterium haemophilum is a nontuberculous mycobacterium that causes skin, joint, bone, and pulmonary infections in immunocompromised persons and lymphadenitis in children. M haemophilum was first isolated ...