Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/28 15:46:05」(JST)
wiki en
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. アレルギー性鼻炎および結膜炎に対する補完代替療法 complementary and alternative therapies for allergic rhinitis and conjunctivitis
English Journal
- Shikonin exerts anti-inflammatory effects in a murine model of lipopolysaccharide-induced acute lung injury by inhibiting the nuclear factor-kappaB signaling pathway.
- Liang D, Sun Y, Shen Y, Li F, Song X, Zhou E, Zhao F, Liu Z, Fu Y, Guo M, Zhang N, Yang Z, Cao Y.Author information Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, People's Republic of China.AbstractShikonin, an analog of naphthoquinone pigments isolated from the root of Lithospermum erythrorhyzon, was recently reported to exert beneficial anti-inflammatory effects both in vivo and in vitro. The present study aimed to investigate the potential therapeutic effect of shikonin in a murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Dexamethasone was used as a positive control to evaluate the anti-inflammatory effect of shikonin in the study. Pretreatment with shikonin (intraperitoneal injection) significantly inhibited LPS-induced increases in the macrophage and neutrophil infiltration of lung tissues and markedly attenuated myeloperoxidase activity. Furthermore, shikonin significantly reduced the concentrations of TNF-α, IL-6 and IL-1β in bronchoalveolar lavage fluid induced by LPS. Compared with the LPS group, lung histopathologic changes were less pronounced in the shikonin-pretreated mice. Additionally, Western blotting results showed that shikonin efficiently decreased nuclear factor-kappaB (NF-κB) activation by inhibiting the degradation and phosphorylation of IκBα. These results suggest that shikonin exerts anti-inflammatory properties in LPS-mediated ALI, possibly through inhibition of the NF-κB signaling pathway, which mediates the expression of pro-inflammatory cytokines. Shikonin may be a potential agent for the prophylaxis of ALI.
- International immunopharmacology.Int Immunopharmacol.2013 Aug;16(4):475-80. doi: 10.1016/j.intimp.2013.04.020. Epub 2013 May 4.
- Shikonin, an analog of naphthoquinone pigments isolated from the root of Lithospermum erythrorhyzon, was recently reported to exert beneficial anti-inflammatory effects both in vivo and in vitro. The present study aimed to investigate the potential therapeutic effect of shikonin in a murine model of
- PMID 23651796
- Traditional chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an anticancer therapy.
- Andújar I, Recio MC, Giner RM, Ríos JL.Author information Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. Vicent Andrés Estellés s/n, 46100-Burjassot, Valencia, Spain.AbstractShikonin is the major constituent of the root of Lithospermum erythrorhizon, which has been used in traditional Chinese medicine to treat external wounds, burns, or dermatitis for centuries. Nowadays, this root is commonly used as an herbal medicine against cancer. Studies carried out over the past 30 years have demonstrated that many of the effects historically associated with the use of this root have a scientific basis, with shikonin and its derivatives being responsible for its pharmacological properties. These include both anti-inflammatory and anticancer effects. While previous summaries have focused on the pharmacokinetics and toxicity of shikonin, the aim of this review is to report on the most current findings with regard to shikonin's antitumor activity by summarizing and comparing the various studies published in the last ten years and discussing the pharmacological aspects that make shikonin a promising anticancer agent.
- Current medicinal chemistry.Curr Med Chem.2013;20(23):2892-8.
- Shikonin is the major constituent of the root of Lithospermum erythrorhizon, which has been used in traditional Chinese medicine to treat external wounds, burns, or dermatitis for centuries. Nowadays, this root is commonly used as an herbal medicine against cancer. Studies carried out over the past
- PMID 23651309
- In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma.
- Rajasekar S, Park da J, Park C, Park S, Park YH, Kim ST, Choi YH, Choi YW.Author information Department of Horticultural Bioscience, Pusan National University, Miryang, Republic of Korea.AbstractETHNOPHARMACOLOGICAL RELEVANCE: Lithospermum erythrorhizon has long been used in traditional Asian medicine for the treatment of diseases including skin cancer. In this study, hexane extract from the roots of Lithospermum erythrorhizon (LEH) was chemically characterized and its anticancer activity was tested against the most aggressive form of skin cancer.
- Journal of ethnopharmacology.J Ethnopharmacol.2012 Nov 21;144(2):335-45. doi: 10.1016/j.jep.2012.09.017. Epub 2012 Sep 17.
- ETHNOPHARMACOLOGICAL RELEVANCE: Lithospermum erythrorhizon has long been used in traditional Asian medicine for the treatment of diseases including skin cancer. In this study, hexane extract from the roots of Lithospermum erythrorhizon (LEH) was chemically characterized and its anticancer activity w
- PMID 22995444
Japanese Journal
- Anti-adenovirus Activities of Shikonin, a Component of Chinese Herbal Medicine in Vitro
- Gao Hong,Liu Lei,Qu Zhang-Yi [他],Wei Feng-xiang,Wang Shu-qiu,Chen Guang,Qin Le,Jiang Fu-yang,Wang Ying-chen,Shang Lei,Gao and Chun-yan
- Biological and Pharmaceutical Bulletin 34(2), 197-202, 2011
- … Radix Lithosperm eyrthrorhizon is a common prescription compound in traditional Chinese medicine. … Shikonin is a major component of Radix Lithospermi and has various biological activities. …
- NAID 130000402189
- Lithospermi radix Extract Inhibits Histamine Release and Production of Inflammatory Cytokine in Mast Cells
- Kim Eun Kyoung,Kim Eun-Young,Moon Phil-Dong [他],UM Jae-Young,KIM Hyung-Min,LEE Hyun-Sam,SOHN Youngjoo,PARK Seong Kyu,JUNG Hyuk-Sang,SOHN Nak-Won
- Bioscience, biotechnology, and biochemistry 71(12), 2886-2892, 2007-12-23
- … <I>Lithospermi radix</I> …
- NAID 10027521698
- Cultivation and preparation of Lithospermum roots quantification of total pigment in slender lateral roots
- Sekizaki Haruo,Yoshida Naotoshi,Hatakeyama Yoshio [他],ASAZU Sandra Naomi,YAMAMOTO Mizuho,HORITA Kiyoshi,NOGUCHI Yukari
- Journal of natural medicines 61(2), 217-219, 2007-05-20
- NAID 10018832950
Related Links
- Radix Arnebiae/Radix Lithospermi/gromwell root/arnebia root / Lithospermum erythrorhizon US $1-123 / Kilogram ( FOB Price) 1 Kilogram (Min. Order) 1000 Kilogram/Kilograms per Day (Supply Ability) Tags: | | Verified Supplier ...
- Radix Lithospermi seu Arnebiae Botanical Name 1. Lithospermun erythrorhizon sieb. et zucc; 2. Arnebia euchroma (Royle Johnst); 3. Macrotomia euchroma Common Name Lithospermun root, Arnebia root, Groomwell root ...
Related Pictures
★リンクテーブル★
| リンク元 | 「紫根」「lithospermum root」 |