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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/20 11:18:02」(JST)

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Fluocinonide (Fluonex, Lidex, Lidex-E, Lonide, Lyderm, and Vanos)^[1] is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.

The usual prescription concentration is 0.05% as a topical cream, ointment, or gel. The application area should normally not be covered after application. In certain cases, the physician may recommend the use of an occlusive dressing after application to increase the rate and depth of absorption. The frequency of application depends on the condition being treated and the area affected, but most often it should be applied 2 to 4 times a day.^[2]

Fluocinonide ranks as a "high-potency" (second-highest rank) topical corticosteroid. Minimal amounts should be used for a minimal length of time to avoid the occurrence of adverse effects.^{[medical citation needed]}.

Fluocinonide should not be used if infection is present. It should not be applied to the eyes or to sensitive areas such as the genitals or anus.^{[medical citation needed]}

A common potential adverse effect is skin atrophy (thinning of the skin). Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal axis (HPA) suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.

Fluocinonide should be used with caution when treating children, pregnant women, nursing mothers, and anyone using the medication for longer than two weeks.

Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs.^[3] Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure.^[4]

References

^ MedlinePlus Drug Information: Fluocinonide Topical
^ "Fluocinonide Topical". MedlinePlus. US National Library of Medicine, NIH. Retrieved 6 March 2014.
^ Dog Allergies www.squidoo.com/dogallergy
^ Zenoble RD, Kemppainen RJ . (1987-09-15). "Adrenocortical suppression by topically applied corticosteroids in healthy dogs". J Am Vet Med Assoc 191 (6): 685–8. PMID 2824410.

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English Journal

Painful Oral Lesions.

Hargitai IA1.
Dental clinics of North America.Dent Clin North Am.2018 Oct;62(4):597-609. doi: 10.1016/j.cden.2018.06.002. Epub 2018 Aug 14.
PMID 30189985

Patients' preferences for different corticosteroid vehicles are highly variable.

Felix K1, Unrue E1, Inyang M1, Cardwell LA1, Oussedik E1, Richardson I1, Feldman SR1,2,3.
The Journal of dermatological treatment.J Dermatolog Treat.2018 May 17:1-18. doi: 10.1080/09546634.2018.1473837. [Epub ahead of print]
PMID 29770722

Marine Develops Chronic Right Knee Granuloma After Initial Injury at The Basic School.

Prak AH1, Dela Rosa KM2.
Military medicine.Mil Med.2018 Mar 14. doi: 10.1093/milmed/usx188. [Epub ahead of print]
PMID 29548037

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★リンクテーブル★

リンク元

「フルオシノニド」

Fluocinonide
Systematic (IUPAC) name
	6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate
Clinical data
Trade names	Lidex
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601054
Pregnancy; category	C;
Legal status	AU: Prescription Only (S4); UK: Prescription-only (POM); US: ℞-only;
Routes of; administration	topical
Pharmacokinetic data
Metabolism	hepatic
Identifiers
CAS Registry Number	356-12-7
ATC code	C05AA11 D07AC08
PubChem	CID: 9642
IUPHAR/BPS	7078
DrugBank	DB01047
UNII	2W4A77YPAN
KEGG	D00325
ChEMBL	CHEMBL1501
Chemical data
Formula	C26H32F2O7
Molecular mass	494.525 g/mol
	SMILES O=C(OCC(=O)[C@]45OC(O[C@@H]5C[C@@H]2[C@@]4(C[C@H](O)[C@]3(F)[C@]/1(/C=C\C(=O)\C=C\1[C@@H](F)C[C@@H]23)C)C)(C)C)C ;
	InChI InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1 ; Key:WJOHZNCJWYWUJD-IUGZLZTKSA-N ;
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英: fluocinonide
商: グリコベース、シマロン、ソルニム、トプシム、ビスコザール、フルオシノニド、ベスタゾン、Fluonex、Lidex

合成副腎皮質ホルモン剤の外用薬
糖質コルチコイド;強力な抗炎症作用;外用

[1] MedlinePlus Drug Information: Fluocinonide Topical

[2] "Fluocinonide Topical". MedlinePlus. US National Library of Medicine, NIH. Retrieved 6 March 2014.

[3] Dog Allergies www.squidoo.com/dogallergy

[4] Zenoble RD, Kemppainen RJ . (1987-09-15). "Adrenocortical suppression by topically applied corticosteroids in healthy dogs". J Am Vet Med Assoc 191 (6): 685–8. PMID 2824410.

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Lidex