L-aminoadipate-semialdehyde dehydrogenase

L-アミノアジピン酸セミアルデヒド脱水素酵素

WordNet

1. the 12th letter of the Roman alphabet (同)l

PrepTutorEJDIC

1. lira(イタリアの貨幣単位リラ)
2. liter[s]

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/09 16:31:52」(JST)

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L-aminoadipate-semialdehyde dehydrogenase
Identifiers
EC number	1.2.1.31
CAS number	9067-87-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31) is an enzyme that catalyzes the chemical reaction

L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H₂O L-2-aminoadipate + NAD(P)H + H⁺

The 4 substrates of this enzyme are L-2-aminoadipate 6-semialdehyde, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are L-2-aminoadipate, NADH, NADPH, and H⁺.

This enzyme participates in lysine biosynthesis and biodegradation.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase. Other names in common use include:

• aminoadipate semialdehyde dehydrogenase,
• 2-aminoadipate semialdehyde dehydrogenase,
• alpha-aminoadipate-semialdehyde dehydrogenase,
• alpha-aminoadipate reductase,
• 2-aminoadipic semialdehyde dehydrogenase,
• L-alpha-aminoadipate delta-semialdehyde oxidoreductase,
• L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase,
• L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine,
• and dinucleotide oxidoreductase.

References

• Calvert AF, Rodwell VW (1966). "Metabolism of pipecolic acid in a Pseudomonas species. 3 L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase". J. Biol. Chem. 241 (2): 409–14. PMID 4285660. 

UpToDate Contents

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• 1. グルコース-6-リン酸脱水素酵素欠損症の診断および治療 diagnosis and treatment of glucose 6 phosphate dehydrogenase deficiency
• 2. 乳酸脱水素酵素欠損症 lactate dehydrogenase deficiency
• 3. グルコース-6-リン酸脱水素酵素欠損症の臨床症状 clinical manifestations of glucose 6 phosphate dehydrogenase deficiency
• 4. ヘキソースリン酸側路およびグルタチオン代謝疾患（グルコース-6-リン酸脱水素酵素欠損症を除く） disorders of the hexose monophosphate shunt and glutathione metabolism other than glucose 6 phosphate dehydrogenase deficiency
• 5. 脂質およびプリン代謝障害による代謝性ミオパチー metabolic myopathies caused by disorders of lipid and purine metabolism

English Journal

• Urinary AASA excretion is elevated in patients with molybdenum cofactor deficiency and isolated sulphite oxidase deficiency.

• Mills PB, Footitt EJ, Ceyhan S, Waters PJ, Jakobs C, Clayton PT, Struys EA.SourceClinical and Molecular Genetics Unit, Institute of Child Health, University College London with Great Ormond Street Hospital for Children NHS Trust, London, WC1N 1EH, UK. p.mills@ucl.ac.uk
• Journal of inherited metabolic disease.J Inherit Metab Dis.2012 Nov;35(6):1031-6. doi: 10.1007/s10545-012-9466-1. Epub 2012 Mar 9.
• Analysis of α-aminoadipic semialdehyde is an important tool in the diagnosis of antiquitin deficiency (pyridoxine-dependent epilepsy). However continuing use of this test has revealed that elevated urinary excretion of α-aminoadipic semialdehyde is not only found in patients with pyridoxine-depend
• PMID 22403017

• Sensitive detection of whole-genome differentiation among closely-related species of the genus Fusarium using DNA-DNA hybridization and a microplate technique.

• Watanabe M, Goto K, Sugita-Konishi Y, Kamata Y, Hara-Kudo Y.SourceDivision of Microbiology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, Japan. : mwatanabe@nihs.go.jp
• The Journal of veterinary medical science / the Japanese Society of Veterinary Science.J Vet Med Sci.2012 Oct;74(10):1333-6. Epub 2012 May 25.
• We developed a new system for detection of whole-genome differentiation using DNA-DNA hybridization, and tested its sensitivity with three closely-related Fusarium species. We compared DNA-DNA relatedness to nucleotide sequence homologies of five genetic regions between each of five strains of three
• PMID 22672840

• Evaluation of genetic markers for identifying isolates of the species of the genus Fusarium.

• Watanabe M, Yonezawa T, Lee K, Kumagai S, Sugita-Konishi Y, Goto K, Hara-Kudo Y.SourceDivision of Microbiology, National Institute of Health Sciences, Tokyo, Japan. mwatanabe@nihs.go.jp
• Journal of the science of food and agriculture.J Sci Food Agric.2011 Oct;91(13):2500-4. doi: 10.1002/jsfa.4507. Epub 2011 Jul 1.
• BACKGROUND: Members of the genus Fusarium are well known as one of the most important plant pathogens causing food spoilage and loss worldwide. Moreover, they are associated with human and animal diseases through contaminated foods because they produce mycotoxins. To control fungal hazards of plants
• PMID 21725977

Related Links

• L-Aminoadipate-Semialdehyde Dehydrogenase

"L-Aminoadipate-Semialdehyde Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). ... This graph shows the total number of publications written ...

• GO:0004043 L-aminoadipate-semialdehyde dehydrogenase ...

The European Bioinformatics Institute ... Database Code Database Name UniProtKB Universal Protein Knowledgebase UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot UniProtKB/TrEMBL UniProtKB-TrEMBL protein sequence database

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★リンクテーブル★

リンク元	「L-アミノアジピン酸セミアルデヒド脱水素酵素」
関連記事	「L」「aminoadipate」「dehydrogenase」「dehydrogenases」

「L-アミノアジピン酸セミアルデヒド脱水素酵素」

　　[★]

英

L-aminoadipate-semialdehyde dehydrogenase

「L」

　　[★]

• リシジン
• リンキング数
• ロイシン
• free ligand concentration

　 　

「aminoadipate」

　　[★]

• アミノアジピン酸、アミノアジピン酸塩

関

aminoadipic acid

「dehydrogenase」

　　[★] 脱水素酵素 デヒドロゲナーゼ

「dehydrogenases」

　　[★] 脱水素酵素 デヒドロゲナーゼ