Kulchitsky細胞
WordNet
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
PrepTutorEJDIC
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/12 13:03:16」(JST)
[Wiki en表示]
Enterochromaffin cell |
|
Serotonin |
Latin |
endocrinocytus EC |
MeSH |
Enterochromaffin+Cells |
Code |
TH H3.04.02.0.00029 |
Enterochromaffin (EC) cells , or "Kulchitsky cells", are a type of enteroendocrine and neuroendocrine cell[1] occurring in the epithelia lining the lumen of the digestive tract and the respiratory tract.
Contents
- 1 Function
- 2 Origin
- 3 Etymology
- 4 "Enterochromaffin-like cells"
- 5 Pathophysiology
- 6 See also
- 7 References
|
Function
They contain about 90% of the body's store of serotonin (5-HT).[2]
In the gastrointestinal tract, 5-HT is important in response to chemical, mechanical or pathological stimuli in the lumen. It activates both secretory and peristaltic reflexes, and activates vagal afferents (via 5-HT3 receptors) that signal to the brain (important in the generation of nausea). Ondansetron is an antagonist of the 5-HT3 receptor and is an effective anti-emetic.
They are stimulated by gastrin, a molecule that is produced at the antrum of the stomach by G cells.
Origin
The enterochromaffin cells are derived from the same stem cells as the rest of the epithelium, and are not derived from the migratory neural crest source that provides the enteric nervous system. [3]
Etymology
They are called "entero"[4] meaning related to the gut and "chromaffin" because of a chromium salt reaction that they share with chromaffin cells of the adrenal medulla (adrenal glands). [5]
"Enterochromaffin-like cells"
Another population of chromaffin cells is found only in the stomach wall, called enterochromaffin-like cells (ECL). They look like EC cells but do not contain 5-HT.
ECL cells respond to gastrin released by G-cells and they release histamine, which will stimulate the parietal cells to produce gastric acid.
Pathophysiology
The neuroendocrine progenitors to enterochromaffin cells in the bronchial epithelium have been implicated in the origin of small cell lung cancer. [6]
See also
- Carcinoid syndrome
- Serotonin
References
- ^ Enterochromaffin Cells at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ Josef Donnerer; Fred Lembeck (2006). The chemical languages of the nervous system: history of scientists and substances. Karger Publishers. pp. 161–. ISBN 978-3-8055-8004-5. Retrieved 23 May 2011.
- ^ Thompson M, Fleming KA, Evans DJ, Fundele R, Surani MA, Wright NA (October 1990). "Gastric endocrine cells share a clonal origin with other gut cell lineages". Development 110 (2): 477–81. PMID 2133551.
- ^ Entero- definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms
- ^ 1516961798 at GPnotebook
- ^ eMedicine - Lung Cancer, Small Cell : Article by Abid Irshad
Digestive system, physiology: gastrointestinal physiology
|
|
GI tract |
Upper GI
|
Exocrine
|
Chief cells (Pepsinogen) · Parietal cells (Gastric acid, Intrinsic factor) · Goblet cells (Mucus)
|
|
Processes
|
Swallowing · Vomiting
|
|
Fluids
|
Saliva · Gastric juice
|
|
|
Lower GI
|
Enteric nervous system
|
Meissner's plexus · Auerbach's plexus
|
|
Endocrine/paracrine
|
G cells (gastrin) · D cells (somatostatin) · ECL cells (Histamine)
enterogastrone: I cells (CCK) · K cells (GIP) · S cells (secretin)
Enteroendocrine cells · Enterochromaffin cell · APUD cell
|
|
Fluids
|
Intestinal juice
|
|
Processes
|
Segmentation contractions · Migrating motor complex · Borborygmus · Defecation
|
|
|
Either/both
|
Processes
|
Peristalsis (Interstitial cell of Cajal · Basal electrical rhythm) · Gastrocolic reflex · Digestion
|
|
|
|
Accessory |
Fluids
|
Bile · Pancreatic juice
|
|
Processes
|
Enterohepatic circulation
|
|
|
Abdominopelvic |
Peritoneal fluid
|
|
|
anat (t, g, p)/phys/devp/enzy
|
noco/cong/tumr, sysi/epon
|
proc, drug (A2A/2B/3/4/5/6/7/14/16), blte
|
|
|
|
Human cell types / list derived primarily from endoderm
|
|
Foregut |
Respiratory
|
Pneumocyte (Type I pneumocyte, Type II pneumocyte) · Clara cell · Goblet cell
|
|
Digestive
|
Stomach
|
enteroendocrine: G cell · D cell · ECL cell
exocrine: Gastric chief cell · Parietal cell
Foveolar cell
|
|
Intestine
|
enteroendocrine: K cell · S cell · D cell · I cell
Goblet cell · Paneth cell
Enterocyte (Microfold cell)
|
|
Liver
|
Hepatocyte · Hepatic stellate cell · (Kupffer cell from mesoderm)
|
|
Gallbladder
|
Cholecystocyte
|
|
Exocrine pancreas
|
Centroacinar cell · Pancreatic stellate cell
|
|
|
Endocrine
|
endocrine pancreas (alpha cell, beta cell, delta cell, F cell(PP cell), epsilon cell)
|
|
|
Pharyngeal pouch |
Endocrine
|
thyroid (Follicular cell) · parathyroid (Parathyroid chief cell, Oxyphil cell)
|
|
|
Hindgut/cloaca |
Urogenital
|
Urothelial cells
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Transient receptor potential cation channels in pancreatic β cells.
- Colsoul B, Vennekens R, Nilius B.SourceDepartment of Molecular Cell Biology, Laboratory of Ion Channel Research, KU Leuven, Campus Gasthuisberg, Herestraat 49, bus 802, 3000 Leuven, Belgium. barbara.colsoul@med.kuleuven.be
- Reviews of physiology, biochemistry and pharmacology.Rev Physiol Biochem Pharmacol.2012;161:87-110.
- There is now overwhelming evidence that TRP channels might play a significant role in the regulation of insulin release from pancreatic β cells, which is until now insufficiently recognized. TRP channels are abundantly expressed on β cells. The focus of this review will be on cation channels from
- PMID 21744203
- The enteroendocrine "letter cells" - time for a new nomenclature?
- Helander HF, Fändriks L.SourceDepartment of Gastrosurgical Research and Education, Institute of Clinical Sciences , Sahlgrenska Academy, University of Gothenburg, Gothenburg , Sweden.
- Scandinavian journal of gastroenterology.Scand J Gastroenterol.2012 Jan;47(1):3-12. Epub 2011 Nov 30.
- Abstract The endocrine cells of the gastrointestinal (GI) tract and the pancreas, referred to as the enteroendocrine cells, secrete a large variety of peptides and amines that regulate functions of the digestive tract itself and of distant organs. Taken together, the enteroendocrine cells form the
- PMID 22126593
Related Links
- Enterochromaffin (EC) cells (Kulchitsky cells) are a type of enteroendocrine cell occurring in the epithelia lining the lumen of the digestive ... They are stimulated by gastrin, a molecule that is produced at the antrum of the stomach by G cells. ...
★リンクテーブル★
[★]
- 英
- Kulchitsky cell, Kulchitsky cells
- 発生は原腸に由来するとされる
- 肺や消化管に分布している。
- 神経内分泌細胞とされる。
- 腫瘍性の増殖を示す疾患は消化管カルチノイドと呼ばれる。
参考
- http://shutoku.fc2web.com/digital_textbook/internal6/disease_of_intestine.html
[★]
[★]
細胞