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Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice.

Sgariglia F, Candela ME, Huegel J, Jacenko O, Koyama E, Yamaguchi Y, Pacifici M, Enomoto-Iwamoto M.SourceTranslational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Bone.Bone.2013 Nov;57(1):220-31. doi: 10.1016/j.bone.2013.08.012. Epub 2013 Aug 17.
Long bones are integral components of the limb skeleton. Recent studies have indicated that embryonic long bone development is altered by mutations in Ext genes and consequent heparan sulfate (HS) deficiency, possibly due to changes in activity and distribution of HS-binding/growth plate-associated
PMID 23958822

Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.

Piao J, Tsuji K, Ochi H, Iwata M, Koga D, Okawa A, Morita S, Takeda S, Asou Y.SourceDepartment of Rehabilitation Medicine, Graduate School, Tokyo Medical and Dental University 1-5-45 Yushima Bunkyo-ku Tokyo Japan, 113-8519.
Scientific reports.Sci Rep.2013 Oct 23;3:3022. doi: 10.1038/srep03022.
Sirtuin 6 (Sirt6) is a mammalian homologue of NAD(+)-dependent histone deacetylase Sir2. Although Sirt6-/- mice exhibit growth retardation, the role of Sirt6 in cartilage metabolism is unclear. The aim of this study was to investigate the Sirt6 signaling pathway in cartilage metabolism. Immunohistol
PMID 24149372

Involvement and targeted intervention of dysregulated hedgehog signaling in osteosarcoma.

Lo WW, Wunder JS, Dickson BC, Campbell V, McGovern K, Alman BA, Andrulis IL.SourceDepartment of Molecular Genetics, University of Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Cancer.Cancer.2013 Oct 21. doi: 10.1002/cncr.28439. [Epub ahead of print]
BACKGROUND: During development, the Hedgehog pathway plays important roles regulating the proliferation and differentiation of chondrocytes, providing a template for growing bone. In this study, the authors investigated the components of dysregulated Hedgehog signaling as potential therapeutic targe
PMID 24151134