- 関
- immunoreceptor tyrosine-based inhibitory motif, ITIM。immunoreceptor tyrosine-based activation motif, ITAM
特徴
- チロシンを持ち、共役するキナーゼによりリン酸化される。
- ....[I/V]XYXX[L/I]....
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/07/13 12:19:19」(JST)
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- 1. 肥満細胞：表面受容体とシグナル伝達 mast cells surface receptors and signal transduction
English Journal
- Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations.
- Sun H, Sun C, Xiao W.SourceInstitute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
- Cytokine.Cytokine.2014 Jan;65(1):33-41. doi: 10.1016/j.cyto.2013.09.016. Epub 2013 Oct 15.
- Co-inhibitory molecules have become the key targets in cancer immunotherapy with the strategy of blocking immune checkpoints to reverse the pathogenic regulation of T cells. However, their expression regulations in NK cells, the most important innate immune cells against tumor, remain largely undefi
- PMID 24139237
- TIGIT regulates NK cell activation in murine acute viral hepatitis.
- Bi J, Zhang Q, Liang D, Xiong L, Wei H, Sun R, Tian Z.SourceDepartment of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China.
- Hepatology (Baltimore, Md.).Hepatology.2013 Dec 9. doi: 10.1002/hep.26968. [Epub ahead of print]
- •Uncontrolled natural killer (NK) cell activation during the early response towards acute viral infection can lead to severe immunopathology, and the mechanisms NK cells use to achieve self-tolerance in such contexts are currently unclear. Here, NK cells upregulated a co-inhibitory receptor, T cel
- PMID 24319005
- Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders.
- Xu TR, Yang Y, Ward R, Gao L, Liu Y.SourceFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China. Electronic address: xtrgfq@hotmail.com.
- Cellular signalling.Cell Signal.2013 Dec;25(12):2413-23. doi: 10.1016/j.cellsig.2013.07.025. Epub 2013 Aug 1.
- The orexin peptides (orexin A, orexin B) and their receptors (orexin receptor type 1, orexin receptor type 2) are involved in multiple physiological processes such as the regulation of sleep/wakefulness state, energy homeostasis and reward seeking. A result of this has been the development of small-
- PMID 23917208
Japanese Journal
- マスト細胞鎮静化と組織恒常性維持 (特集 慢性炎症と疾病)
- 倉島 洋介,小暮 優太,福井 渉 [他]
- 臨床免疫・アレルギー科 = Clinical immunology & allergology 63(6), 551-557, 2015-06
- NAID 40020505003
- クラススイッチしたB細胞における新規な負の調節因子 (特集 免疫記憶と疾病)
- 藤堂 景史,疋田 正喜
- 臨床免疫・アレルギー科 = Clinical immunology & allergology 63(6), 532-537, 2015-06
- NAID 40020504928
- 免疫グロブリンスーパーファミリー
- 井上 修
- 日本血栓止血学会誌 26(1), 21-28, 2015
- 要約：Immunoglobulin-superfamily（Ig-SF）は原始的な生物にも存在する膜蛋白である．生命の進化に合わせ機能が継ぎ足され，現在は数千種類の多様性を持つ一大ファミリーとなった．その一部は，血栓止血の中心的な役割を担う血小板でも，膜蛋白として利用されている．傷からの出血を早く止めることが生存競争の重要課題であった哺乳類では，血小板膜上にIg-SF を持つことが迅速な血栓止血に …
- NAID 130004847368
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★リンクテーブル★
| リンク元 | 「ITAM」「免疫受容抑制性チロシンモチーフ」「immunoreceptor tyrosine-based inhibitory motif」 |
| 関連記事 | 「IT」「ITIMs」 |
「ITAM」
- 日
- 免疫受容活性化チロシンモチーフ
- 英
- immunoreceptor tyrosine-based activation motif, immunoreceptor tyrosine based activation motifs
- 同
- ARAM, antigen recognition activation motif
- 関
- ITIM immunoreceptor tyrosine-based inhibition motif、immunoreceptor tyrosine-based activating motifs ITAMs
ITAMを有する分子で分類
1つ有する
3つ有する
受容体で分類
BCRからのシグナル伝達
- B細胞のIgα, Igβ
TCRからのシグナル伝達
- T細胞のCD3, CD3, CD3, ζ
NK細胞受容体以下のシグナル伝達
- NK細胞のNKR？、NIR？
Fc受容体以下のシグナル伝達
- Fc受容体をもつ肥満細胞、マクロファージ、単球、好中球、NK細胞
特徴
- チロシンを持ち、共役するキナーゼによりリン酸化される。
- ....YXX[L/I]X6-9YXX[L/I]....
「免疫受容抑制性チロシンモチーフ」
「immunoreceptor tyrosine-based inhibitory motif」
- 関
- ITIM
「IT」
- 核異性体転移 nuclear isomeric transition isomeric transition
- inspiratory time
- 髄腔内 intrathecal