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Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12.

Paradowska-Gorycka A, Jurkowska M.SourceDepartment of Biochemistry and Molecular Biology, Institute of Rheumatology, Warsaw, Poland. Electronic address: paradowska_aga@interia.pl.
Human immunology.Hum Immunol.2013 Jun;74(6):730-7. doi: 10.1016/j.humimm.2013.02.003. Epub 2013 Feb 28.
DNAX-activating protein of 12kDa (DAP12) is a member of type I transmembrane adapter proteins containing immunoreceptor tyrosine-based activation motifs (ITAMs). In humans DAP12 gene is located on chromosome 19q13.1. DAP12 forms a molecular complex with triggering receptor expressed on myeloid cells
PMID 23459077

Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by distinct nonreceptor tyrosine kinases: a case study involving PECAM-1.

Tourdot BE, Brenner MK, Keough KC, Holyst T, Newman PJ, Newman DK.SourceBlood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Biochemistry.Biochemistry.2013 Apr 16;52(15):2597-608. doi: 10.1021/bi301461t. Epub 2013 Apr 3.
The activation state of many blood and vascular cells is tightly controlled by a delicate balance between receptors that contain immunoreceptor tyrosine-based activation motifs (ITAMs) and those that contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Precisely how the timing of cellula
PMID 23418871

Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.

Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ.SourceBlood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA.
Blood.Blood.2013 Mar 7;121(10):1858-67. doi: 10.1182/blood-2012-07-443325. Epub 2012 Dec 20.
The integrin family is composed of a series of 24 αβ heterodimer transmembrane adhesion receptors that mediate cell-cell and cell-extracellular matrix interactions. Adaptor molecules bearing immunoreceptor tyrosine-based activation motifs (ITAMs) have recently been shown to cooperate with specific
PMID 23264598

Qualitatively differential regulation of T cell activation and apoptosis by T cell receptor ζ chain ITAMs and their tyrosine residues

CHAE Wook-Jin,LEE Heung-Kyu,HAN Jin-Hwan,KIM Sang-Won Vincent,BOTHWELL Alfred L. M.,MORIO Tomohiro,LEE Sang-Kyou
International immunology 16(9), 1225-1236, 2004-09-01
NAID 10013503814