- 関
- IL7 receptor、interleukin-7 receptor
WordNet
- the 9th letter of the Roman alphabet (同)i
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 『私は』私が
- iodineの化学記号
- =sense organ / 受信装置
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Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/06 23:10:48」(JST)
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IL-7 receptor and signaling, common γ chain (blue) and IL-7 receptor-α (green)
| Interleukin-7 receptor-α |
| Identifiers |
| Symbol |
IL7R |
| Alt. symbols |
CD127 |
| Entrez |
3575 |
| HUGO |
6024 |
| OMIM |
146661 |
| RefSeq |
NM_002185 |
| UniProt |
P16871 |
| Other data |
| Locus |
Chr. 5 p13 |
| interleukin 2 receptor, gamma |
|
| Identifiers |
| Symbol |
IL2RG |
| Alt. symbols |
SCIDX1, IMD4, CD132 |
| Entrez |
3561 |
| HUGO |
6010 |
| OMIM |
308380 |
| RefSeq |
NM_000206 |
| UniProt |
P31785 |
| Other data |
| Locus |
Chr. X q13 |
The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132).[1][2] The common-γ chain receptors is shared with various cytokines, including interleukin-2, -4, -9, and -15.[3] Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others.
Contents
- 1 Function
- 2 Diseases
- 3 See also
- 4 References
- 5 External links
Function
Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination[citation needed]. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation[citation needed]. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).[4]
Diseases
Several diseases are associated with Interleukin-7 receptor including T-cell acute lymphoblastic leukaemia,[5] multiple sclerosis,[6] rheumatoid arthritis and juvenile idiopathic arthritis.[7]
See also
- Cluster of differentiation
References
- ^ Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ (December 1993). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor". Science. 262 (5141): 1877–80. PMID 8266077. doi:10.1126/science.8266077.
- ^ Kroemer RT, Richards WG (December 1996). "Homology modeling study of the human interleukin-7 receptor complex". Protein Eng. 9 (12): 1135–42. PMID 9010926. doi:10.1093/protein/9.12.1135.
- ^ "IL2 family". Guide to Pharmacology. IUPHAR/BPS. Retrieved 21 August 2015.
- ^ "Entrez Gene: IL7R interleukin 7 receptor".
- ^ Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT (October 2011). "Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia". Nat. Genet. 43 (10): 932–9. PMID 21892159. doi:10.1038/ng.924.
- ^ Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL (September 2007). "Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis". Nat. Genet. 39 (9): 1083–91. PMID 17660817. doi:10.1038/ng2103.
- ^ O'Doherty C, Alloza I, Rooney M, Vandenbroeck K (November 2009). "IL7RA polymorphisms and chronic inflammatory arthropathies". Tissue Antigens. 74 (5): 429–31. PMID 19744146. doi:10.1111/j.1399-0039.2009.01342.x.
External links
- IL7R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
Cytokine receptors
|
Chemokine receptor
(GPCRs) |
| CC |
- CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
|
| CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
|
| Other |
|
|
| TNF receptor |
| 1-10 |
- TNFR1 (TNFRSF1A)
- TNFR2 (TNFRSF1B)
- LTBR (TNFRSF3)
- CD134 (TNFRSF4)
- CD40 (TNFRSF5)
- Fas receptor (TNFRSF6)
- DcR3 (TNFRSF6B)
- CD27 (TNFRSF7)
- CD30 (TNFRSF8)
- CD137 (TNFRSF9)
|
| 11-20 |
- DR4 (TNFRSF10A)
- DR5 (TNFRSF10B)
- DcR1 (TNFRSF10C)
- DcR2 (TNFRSF10D)
- RANK (TNFRSF11A)
- Osteoprotegerin (TNFRSF11B)
- TweakR (TNFRSF12A)
- TACI (TNFRSF13B)
- BAFFR (TNFRSF13C)
- HVEM (TNFRSF14)
- NGFR (TNFRSF16)
- BCMA (TNFRSF17)
- GITR (TNFRSF18)
- TAJ/TROY (TNFRSF19)
|
| 21-27 |
- DR6 (TNFRSF21)
- DR3 (TNFRSF25)
- EDA2R (TNFRSF27)
|
|
| JAK-STAT |
| Type I |
| γ-chain |
- Interleukin receptors
- IL2R / IL2RA/IL2RB / IL15R
- IL4R / IL13R / IL13RA1 / IL13RA2
- IL7R / IL7RA
- IL9R
- IL21R
|
| β-chain |
- Interleukin receptors
- IL3R / IL3RA
- IL5R / IL5RA
- GM-CSF
|
| gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
|
| IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
|
| Other |
- hormone receptor: GH
- prolactin
|
|
| Type II |
- Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
- Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2
|
|
| Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R / IL18R1
|
| IL 17 family |
- IL17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
|
| S/T |
|
|
Interleukin receptor modulators
|
| IL-1 |
- Agonists: Interleukin 1 (α, β)
- Mobenakin
- Pifonakin
- Antagonists: AF-12198
- Anakinra
- IL-1RA
- Isunakinra
- Antibodies: Canakinumab
- Gevokizumab
- Lutikizumab
- Decoy receptors: Rilonacept (IL-1 Trap)
|
| IL-2 |
- Agonists: Adargileukin alfa
- Aldesleukin
- Celmoleukin
- Denileukin diftitox
- Interleukin 2
- Pegaldesleukin
- Teceleukin
- Tucotuzumab celmoleukin
- Antibodies: Basiliximab
- Daclizumab (dacliximab)
- Inolimomab
|
| IL-3 |
- Agonists: Daniplestim
- Interleukin 3
- Leridistim
- Milodistim
- Muplestim
- Promegapoietin
|
| IL-4 |
- Agonists: Binetrakin
- Interleukin 4
- Interleukin 13
- Antibodies: Dupilumab
- Pascolizumab
|
| IL-5 |
- Antibodies: Benralizumab
- Mepolizumab
- Reslizumab
- Antisense oligonucleotides: TPI ASM8
|
| IL-6 |
- Agonists: Atexakin alfa
- Interleukin 6
- Antibodies: ARGX-109
- Clazakizumab
- Elsilimomab
- mAb 1339
- Olokizumab
- Sarilumab
- Siltuximab
- Sirukumab
- Tocilizumab
|
| IL-7 |
|
| IL-8 |
- See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) here instead.
|
| IL-9 |
|
| IL-10 |
- Agonists: Ilodecakin
- Interleukin 10 (CSIF)
|
| IL-11 |
- Agonists: Interleukin 11 (AGIF)
- Oprelvekin
|
| IL-12 |
- Agonists: Edodekin alfa
- Interleukin 12
- Antibodies: Briakinumab
- Ustekinumab
|
| IL-13 |
- Agonists: Binetrakin
- Cintredekin besudotox
- Interleukin 4
- Interleukin 13
- Antibodies: Anrukinzumab
- Lebrikizumab
- Tralokinumab
|
| IL-15 |
- Agonists: ALT-803
- Interleukin 15
|
| IL-17 |
- Agonists: Interleukin 17 (A, B, C, D, E (interleukin 25), F)
- Antibodies: Brodalumab
- Ixekizumab
- Perakizumab
- Remtolumab
- Secukinumab
- Vunakizumab
|
| IL-18 |
- Agonists: Iboctadekin
- Interleukin 18
- Interleukin 37
- Tadekinig
|
| IL-20 |
- Agonists: Interleukin 19
- Interleukin 20
- Interleukin 24
- Antibodies: Fletikumab (against IL-20)
|
| IL-21 |
- Agonists: Denenicokin
- Interleukin 21
- Antibodies: NNC0114-0005
- NNC0114-0006
|
| IL-22 |
- Antibodies: Fezakinumab (against IL-22)
|
| IL-23 |
- Agonists: Interleukin 23 (SGRF)
- Antibodies: Brazikumab
- Briakinumab
- Guselkumab
- Tildrakizumab
- Ustekinumab
|
| IL-27 |
- Agonists: Interleukin 27 (interleukin 30)
|
| IL-28 |
- Agonists: Interferon λ4 (IFN-λ4)
- Interleukin 28 (A (IFN-λ2), B (IFN-λ3))
- Interleukin-29 (IFN-λ1)
|
| IL-31 |
|
| IL1RL1 |
|
| IL1RL2 |
- Agonists: Interleukin 36 (α, β, γ)
- Interleukin 38
|
| Others |
|
JAK
|
|
|
Others
|
- Interleukin 14 (taxilin alpha, HMW-BCGF)
- Interleukin 16 (signals through CD4)
- Interleukin 24 (signals through IL-22Rα1/IL-20Rβ heterodimer)
- Interleukin 26 (signals through IL-20Rα/IL-10Rβ heterodimer)
- Interleukin 32
- Interleukin 34 (signals through M-CSFR/CSF1R)
- Interleukin 35
|
|
- See also: Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Cytokine receptor modulators
|
UpToDate Contents
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English Journal
- Reduced IL-7R T Cell Expression and Increased Plasma sCD127 in Late Presenting HIV-Infected Individuals.
- Hartling HJ1, Jespersen S, Gaardbo JC, Sambleben C, Thorsteinsson K, Gerstoft J, Ullum H, Nielsen SD.
- Journal of acquired immune deficiency syndromes (1999).J Acquir Immune Defic Syndr.2017 Jan 1;74(1):81-90.
- BACKGROUND: Late presentation of HIV infection is associated with reduced chance of optimal immune recovery after initiating combination antiretroviral therapy (cART). Interleukin-7 (IL-7) and the corresponding receptor, IL-7 receptor (IL-7R) made up of CD127 and CD132, are crucial for T cell homeos
- PMID 27509242
- Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation.
- Cordeiro Gomes A1, Hara T2, Lim VY3, Herndler-Brandstetter D3, Nevius E3, Sugiyama T4, Tani-Ichi S5, Schlenner S6, Richie E7, Rodewald HR8, Flavell RA9, Nagasawa T4, Ikuta K5, Pereira JP10.
- Immunity.Immunity.2016 Nov 23. pii: S1074-7613(16)30476-9. doi: 10.1016/j.immuni.2016.11.004. [Epub ahead of print]
- Hematopoietic stem cells (HSCs) self-renew in bone marrow niches formed by mesenchymal progenitors and endothelial cells expressing the chemokine CXCL12, but whether a separate niche instructs multipotent progenitor (MPP) differentiation remains unclear. We show that MPPs resided in HSC niches, wher
- PMID 27913094
- IL-7/IL-7 receptor axis stimulates prostate cancer cell invasion and migration via AKT/NF-κB pathway.
- Qu H1, Zou Z2, Pan Z2, Zhang T2, Deng N2, Chen G2, Wang Z3.
- International immunopharmacology.Int Immunopharmacol.2016 Nov;40:203-210. doi: 10.1016/j.intimp.2016.08.017. Epub 2016 Sep 7.
- IL-7, acting via IL-7 receptor (IL-7R), plays an important role in tumor progression. Elevated IL-7 expression has been reported to be observed in prostate cancer tissues and closely associated with poor prognosis. However, the biological functions of IL-7 and its receptor in prostate cancer cell in
- PMID 27611862
Japanese Journal
- Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations.
- Tani-ichi Shizue,Shimba Akihiro,Wagatsuma Keisuke,Miyachi Hitoshi,Kitano Satsuki,Imai Kumiko,Hara Takahiro,Ikuta Koichi
- Proceedings of the National Academy of Sciences of the United States of America 110(2), 612-617, 2013-01-08
- … Interleukin (IL)-7 is a cytokine essential for T lymphocyte development and homeostasis. … However, little is known about the roles of IL-7 receptor α-chain (IL-7Rα) in late stages of T-cell development. … To address this question, we established IL-7Rα-floxed mice and crossed them with CD4-Cre transgenic mice. …
- NAID 120005241695
- 胸腺上皮細胞が産生するサイトカインとT細胞の分化 (特集 胸腺におけるT細胞の分化とその機序)
- IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells
- FALLER Elliott,KAKAL Juzer,KUMAR Ritesh,MACPHERSON Paul
- International immunology 21(3), 203-216, 2009-03-01
- NAID 10025384480
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