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Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia–lymphoma cells

Taniguchi Hiroaki,Hasegawa Hiroo,Sasaki Daisuke,Ando Koji,Sawayama Yasushi,Imanishi Daisuke,Taguchi Jun,Imaizumi Yoshitaka,Hata Tomoko,Tsukasaki Kunihiro,Uno Naoki,Morinaga Yoshitomo,Yanagihara Katsunori,Miyazaki Yasushi
Cancer Science 105(12), 1601-1608, 2014-12-01
… AUY922 caused strong upregulation of HSP70, a surrogate marker of HSP90 inhibition, and a dose-dependent decrease in HSP90 client proteins associated with cell survival, proliferation, and cell cycle in the G1 phase, including phospho-Akt, Akt, IKKα, IKKβ, IKKγ, Cdk4, Cdk6, and survivin. …
NAID 120005526601

Polyubiquitination Events Mediate Polymethylmethacrylate (PMMA) Particle Activation of NF-κB Pathway

山中康裕,Karuppaiah Kannan,Abu-Ame Yousef
Journal of Biological Chemistry 286(27), 23735-23741, 2011
… The former pathway requires assembly of large IKK complex encompassing IKK1, IKK2, and IKKγ/NEMO. …
NAID 120004461834

Functional Role of c-Src in IL-1-Induced NF-κB Activation : c-Src Is a Component of the IKK Complex

Funakoshi-Tago Megumi,Tago Kenji,Andoh Kumi [他],SONODA Yoshiko,TOMINAGA Shin-ichi,KASAHARA Tadashi
The journal of biochemistry 137(2), 189-197, 2005-02-01
NAID 10017343171