- 関
- ELAV protein、Hu antigen
WordNet
- the 8th letter of the Roman alphabet (同)h
- any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
- inflammation of the brain and spinal cord
PrepTutorEJDIC
- hydrogenの化学記号
- 鉛筆の硬度 / 《俗》heroin
- 抗原(生物の体内にはいって免疫体を作る物質)
UpToDate Contents
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English Journal
- Peripheral neuropathies associated with antibodies directed to intracellular neural antigens.
- Antoine JC1.
- Revue neurologique.Rev Neurol (Paris).2014 Oct;170(10):570-6. doi: 10.1016/j.neurol.2014.07.002. Epub 2014 Sep 4.
- Antibodies directed to intracellular neural antigens have been mainly described in paraneoplastic peripheral neuropathies and mostly includes anti-Hu and anti-CV2/CRMP5 antibodies. These antibodies occur with different patterns of neuropathy. With anti-Hu antibody, the most frequent manifestation is
- PMID 25194475
- Therapeutic approaches in antibody-associated central nervous system pathologies.
- Honnorat J1.
- Revue neurologique.Rev Neurol (Paris).2014 Oct;170(10):587-94. doi: 10.1016/j.neurol.2014.07.007. Epub 2014 Sep 2.
- Initially, antibodies targeting intracellular compounds were described in patients with paraneoplastic neurological syndromes (PNS) such as anti-Hu, anti-Yo, anti-Ri or anti-CV2/CRMP5 antibodies. As more than 90% of patients with these antibodies suffer from an associated cancer, these antibodies we
- PMID 25189679
- Neuronal uptake of anti-Hu antibody, but not anti-Ri antibody, leads to cell death in brain slice cultures.
- Greenlee JE, Clawson SA, Hill KE, Wood B, Clardy SL, Tsunoda I, Jaskowski TD, Carlson NG.
- Journal of neuroinflammation.J Neuroinflammation.2014 Sep 17;11:160. doi: 10.1186/s12974-014-0160-0.
- BACKGROUND: Anti-Hu and anti-Ri antibodies are paraneoplastic immunoglobulin (Ig)G autoantibodies which recognize cytoplasmic and nuclear antigens present in all neurons. Although both antibodies produce similar immunohistological labeling, they recognize different neuronal proteins. Both antibodies
- PMID 25228406
Japanese Journal
- The expression of the Hu (Paraneoplastic encephalomyelitis/sensory neuropathy) antigen in human normal and tumor tissues
Related Links
- 1. Cell. 1991 Oct 18;67(2):325-33. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. Szabo A, Dalmau J, Manley G, Rosenfeld M, Wong E, Henson J, Posner ...
- Posner JB, Furneaux HM. Paraneoplastic syndromes. Res Publ Assoc Res Nerv Ment Dis. 1990; 68:187–219. [PubMed] Dalmau J, Furneaux HM, Rosenblum MK, Graus F, Posner JB. Detection of the anti-Hu antibody in specific ...
★リンクテーブル★
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- 関
- ELAV protein、Hu paraneoplastic encephalomyelitis antigen
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- 英
- Hu paraneoplastic encephalomyelitis antigen、Hu antigen
- 関
- ELAVタンパク質、Hu抗原
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ELAVタンパク質
- 関
- Hu antigen、Hu paraneoplastic encephalomyelitis antigen
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傍腫瘍性脳脊髄症、腫瘍随伴脳脊髄症、腫瘍随伴性脳脊髄症
- 関
- nervous system paraneoplastic syndrome
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