WordNet

the state of being joined together (同)conjunction, conjugation, colligation
an act of joining or adjoining things (同)adjunction
something that joins or connects (同)conjunction
the place where two or more things come together

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〈U〉〈C〉連結すること(された状態),『結合』,連合,合体 / 〈C〉『結合点』,連結(接合,合流)点 / 〈C〉(鉄道の)『連絡駅』,接続駅

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/15 15:32:49」(JST)

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Crossover junction endodeoxyribonuclease (EC 3.1.22.4, Hje endonuclease, Holliday junction endonuclease CCE1, Holliday junction resolvase, Holliday junction-cleaving endonuclease, Holliday junction-resolving endoribonuclease, RusA Holliday junction resolvase, RusA endonuclease, RuvC endonuclease, SpCCe1 Holliday junction resolvase, crossover junction endoribonuclease, cruciform-cutting endonuclease, endo X3, endonuclease RuvC, endonuclease VII, endonuclease X3, resolving enzyme CCE1) is an enzyme.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)

The enzyme from Saccharomyces cerevisiae is not active on DNA molecules that do not contain Holliday junctions.

References[edit]

^ Symington, L.S. and Kolodner, R. (1985). "Partial purification of an enzyme from Saccharomyces cerevisiae that cleaves Holliday junctions". Proc. Natl. Acad. Sci. USA 82: 7247–7251. PMID 3903750.
^ Shida, T., Iwasaki, H., Saito, A., Kyogoku, Y. and Shinagawa, H. (1996). "Analysis of substrate specificity of the RuvC holliday junction resolvase with synthetic Holliday junctions". J. Biol. Chem. 271: 26105–26109. PMID 8824253.
^ Shah, R., Cosstick, R. and West, S.C. (1997). "The RuvC protein dimer resolves Holliday junctions by a dual incision mechanism that involves base-specific contacts". EMBO J. 16: 1464–1472. PMID 9135161.
^ Fogg, J.M., Schofield, M.J., White, M.F. and Lilley, D.M. (1999). "Sequence and functional-group specificity for cleavage of DNA junctions by RuvC of Escherichia coli". Biochemistry 38: 11349–11358. PMID 10471285.
^ Middleton, C.L., Parker, J.L., Richard, D.J., White, M.F. and Bond, C.S. (2003). "Crystallization and preliminary X-ray diffraction studies of Hje, a Holliday junction resolving enzyme from Sulfolobus solfataricus". Acta Crystallogr. D Biol. Crystallogr. 59: 171–173. PMID 12499561.

External links[edit]

Crossover junction endodeoxyribonuclease at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Effect of GEN1 interference on the chemosensitivity of the breast cancer MCF-7 and SKBR3 cell lines.

Wu Y1, Qian Y2, Zhou G2, Lv J2, Yan Q1, Dong X1.
Oncology letters.Oncol Lett.2016 Jun;11(6):3597-3604. Epub 2016 Apr 21.
Chemotherapy is a notable method for the treatment of breast cancer. Numerous genes associated with the sensitivity of cancer to chemotherapy have been found. In recent years, evidence has suggested that a particular structure termed Holliday junction (HJ) plays a crucial role in cancer chemosensiti
PMID 27284361

Structure and Metal Binding Properties of a Poxvirus Resolvase.

Li H1, Hwang Y2, Perry K3, Bushman F4, Van Duyne GD5.
The Journal of biological chemistry.J Biol Chem.2016 May 20;291(21):11094-104. doi: 10.1074/jbc.M115.709139. Epub 2016 Mar 24.
Poxviruses replicate their linear genomes by forming concatemers that must be resolved into monomeric units to produce new virions. A viral resolvase cleaves DNA four-way junctions extruded at the concatemer junctions to produce monomeric genomes. This cleavage reaction is required for viral replica
PMID 27013661

Mycobacterium tuberculosis RuvX is a Holliday junction resolvase formed by dimerisation of the monomeric YqgF nuclease domain.

Nautiyal A1, Rani PS1, Sharples GJ2, Muniyappa K1.
Molecular microbiology.Mol Microbiol.2016 May;100(4):656-74. doi: 10.1111/mmi.13338. Epub 2016 Apr 1.
The Mycobacterium tuberculosis genome possesses homologues of the ruvC and yqgF genes that encode putative Holliday junction (HJ) resolvases. However, their gene expression profiles and enzymatic properties have not been experimentally defined. Here we report that expression of ruvC and yqgF is indu
PMID 26817626

Japanese Journal

Direct analysis of Holliday junction resolving enzyme in a DNA origami nanostructure.

Suzuki Yuki,Endo Masayuki,Cañas Cristina,Ayora Silvia,Alonso Juan C,Sugiyama Hiroshi,Takeyasu Kunio
Nucleic acids research 42(11), 7421-7428, 2014-05
… Holliday junction (HJ) resolution is a fundamental step for completion of homologous recombination. … HJ resolving enzymes (resolvases) distort the junction structure upon binding and prior cleavage, raising the possibility that the reactivity of the enzyme can be affected by a particular geometry and topology at the junction. …
NAID 120005458291

The OsGEN-L protein from Oryza sativa possesses Holliday junction resolvase activity as well as 5'-flap endonuclease activity

YANG Yantao,ISHINO Sonoko,YAMAGAMI Takeshi,KUMAMARU Toshihiro,SATOH Hikaru,ISHINO Yoshizumi
The journal of biochemistry 151(3), 317-327, 2012-03-01
NAID 10031166070

The OsGEN-L protein from Oryza sativa possesses Holliday junction resolvase activity as well as 5'-flap endonuclease activity

Yang Yantao,Ishino Sonoko,Yamagami Takeshi [他]
Journal of Biochemistry 151(3), 317-327, 2012-03
NAID 40019186039

「Hollidayジャンクションリゾルバーゼ」

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PMC	articles
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Crossover junction endodeoxyribonuclease
Identifiers
EC number	3.1.22.4
CAS number	99676-43-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
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　　[★]

英: Holliday junction resolvase
関: ホリデイジャンクションリゾルバーゼ

「ホリデイジャンクションリゾルバーゼ」

　　[★]

英: Holliday junction resolvase
関: Hollidayジャンクションリゾルバーゼ

「junction」

　　[★]

n.

接合部、移行部、接合点、ジャンクション

関: junctional、junctional region、juncture

「Holliday junction」

　　[★]

ホリデイジャンクション、ホリデイ構造、Hollidayジャンクション

関: cruciform DNA

「resolvase」

　　[★]

リゾルバーゼ、リゾルベース

関: recombinase

[1] Symington, L.S. and Kolodner, R. (1985). "Partial purification of an enzyme from Saccharomyces cerevisiae that cleaves Holliday junctions". Proc. Natl. Acad. Sci. USA 82: 7247–7251. PMID 3903750.

[2] Shida, T., Iwasaki, H., Saito, A., Kyogoku, Y. and Shinagawa, H. (1996). "Analysis of substrate specificity of the RuvC holliday junction resolvase with synthetic Holliday junctions". J. Biol. Chem. 271: 26105–26109. PMID 8824253.

[3] Shah, R., Cosstick, R. and West, S.C. (1997). "The RuvC protein dimer resolves Holliday junctions by a dual incision mechanism that involves base-specific contacts". EMBO J. 16: 1464–1472. PMID 9135161.

[4] Fogg, J.M., Schofield, M.J., White, M.F. and Lilley, D.M. (1999). "Sequence and functional-group specificity for cleavage of DNA junctions by RuvC of Escherichia coli". Biochemistry 38: 11349–11358. PMID 10471285.

[5] Middleton, C.L., Parker, J.L., Richard, D.J., White, M.F. and Bond, C.S. (2003). "Crystallization and preliminary X-ray diffraction studies of Hje, a Holliday junction resolving enzyme from Sulfolobus solfataricus". Acta Crystallogr. D Biol. Crystallogr. 59: 171–173. PMID 12499561.

リンク元	「Hollidayジャンクションリゾルバーゼ」「ホリデイジャンクションリゾルバーゼ」
関連記事	「junction」「Holliday junction」「resolvase」

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案内

Holliday junction resolvase