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English Journal

Tandem mass spectrometry analysis of linoleic and arachidonic acid hydroperoxides via promotion of alkali metal adduct formation.

Ito J1, Mizuochi S1, Nakagawa K1, Kato S1, Miyazawa T1.
Analytical chemistry.Anal Chem.2015 May 5;87(9):4980-7. doi: 10.1021/acs.analchem.5b00851. Epub 2015 Apr 24.
Recently, we demonstrated that tandem mass spectrometry (MS/MS) analysis in the presence of sodium ions was useful for identification of the position of the hydroperoxy group in phosphatidylcholine hydroperoxide (PCOOH). Likewise, MS/MS may enable identification of the hydroperoxy group position in
PMID 25874840

Impact of myeloperoxidase-derived oxidants on the product profile of human 5-lipoxygenase.

Zschaler J1, Dorow J2, Schöpe L3, Ceglarek U2, Arnhold J4.
Free radical biology & medicine.Free Radic Biol Med.2015 Apr 22;85:148-156. doi: 10.1016/j.freeradbiomed.2015.04.015. [Epub ahead of print]
Human 5-lipoxygenase (5-LOX) oxidizes arachidonic acid to 5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HpETE) and leukotriene (LT) A4. In neutrophils, LTA4 is further converted to the potent chemoattractant LTB4. These cells also contain the heme enzyme myeloperoxidase (MPO), which produces
PMID 25912480

Mutagenesis of triad determinants of rat Alox15 alters the specificity of fatty acid and phospholipid oxygenation.

Pekárová M1, Kuhn H2, Bezáková L3, Ufer C2, Heydeck D4.
Archives of biochemistry and biophysics.Arch Biochem Biophys.2015 Apr 1;571:50-7. doi: 10.1016/j.abb.2015.02.029. Epub 2015 Feb 27.
Among lipoxygenases ALOX15 orthologs are somewhat peculiar because of their capability of oxygenating polyenoic fatty acids even if they are incorporated in complex lipid-protein assemblies. ALOX15 orthologs of different species have been characterized before, but little is known about the correspon
PMID 25731857

High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade.

Okada Yukio,Imendra Kotapola G,Miyazaki Toshihiro,Hotokezaka Hitoshi,Fujiyama Rie,Toda Kazuo
PLoS One 6(4), e19158, 2011-04-29
… IP(3) dialysis failed to induce conductance increase, but 2-arachidonoylglycerol (2-AG), arachidonic acid and 12S-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(S)-HPETE) dialysis increased the conductance identical to extracellular Ca(2+)-induced conductance. …
NAID 120003238497

Role of Leukotriene B4 in 5-Lipoxygenase Metabolite- and Allergy-Induced Itch-Associated Responses in Mice

Tsuji Fumio,Aono Hiroyuki,Tsuboi Takashi [他],Murakami Tadahiro,Enomoto Hiroshi,Mizutani Keiko,Inagaki Naoki
Biological and Pharmaceutical Bulletin 33(6), 1050-1053, 2010
… Itch-associated responses were induced by intradermal injection of 5-hydroperoxyeicosatetraenoic acid (HPETE), a precursor of 5-lipoxygenase metabolites, and passive cutaneous anaphylaxis in ICR mice. … 5-HPETE induced scratching behavior, which was inhibited by SA6541 (100 mg/kg). … However, SA6541 (100 mg/kg) hardly attenuated the 5-HPETE-induced increase in vascular permeability. …
NAID 130000247978

Kanamoto Hirosuke,Takemura Miho,Ohyama Kanji
Bioscience, biotechnology, and biochemistry 73(11), 2549-2551, 2009-11-23
… LC/MS/MS analysis indicated that the liverwort 5-LOX produced 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid (5-HPETE) with arachidonic acid as a substrate. …
NAID 10027548337