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English Journal

Oxidizing substrate specificity of Mycobacterium tuberculosis alkyl hydroperoxide reductase E: kinetics and mechanisms of oxidation and overoxidation.

Reyes AM, Hugo M, Trostchansky A, Capece L, Radi R, Trujillo M.SourceDepartamento de Bioquímica, Universidad de la República, 11800 Montevideo, Uruguay.
Free radical biology & medicine.Free Radic Biol Med.2011 Jul 15;51(2):464-73. Epub 2011 Apr 17.
Alkyl hydroperoxide reductase E (AhpE), a novel subgroup of the peroxiredoxin family, comprises Mycobacterium tuberculosis AhpE (MtAhpE) and AhpE-like proteins present in many bacteria and archaea, for which functional characterization is scarce. We previously reported that MtAhpE reacted ~10(3) tim
PMID 21571062

Riahi Y, Cohen G, Shamni O, Sasson S.SourceDept. of Pharmacology, The Hebrew Univ. Jerusalem 91120, Israel.
American journal of physiology. Endocrinology and metabolism.Am J Physiol Endocrinol Metab.2010 Dec;299(6):E879-86. Epub 2010 Sep 21.
The peroxidation of n-3 and n-6 polyunsaturated fatty acids (PUFAs) and of their hydroperoxy metabolites is a complex process. It is initiated by free oxygen radical-induced abstraction of a hydrogen atom from the lipid molecule followed by a series of nonenzymatic reactions that ultimately generate
PMID 20858748

Measurement of Lipid Hydroperoxides by the Ferric-Xylenol Orange Method (2) Application to Lipoxygenase Assay

Fukuzawa Kenji,Sano Masumi,Akai Kaori [他],Morishige Junichi,Tokumura Akira,Jisaka Mituo
Journal of nutritional science and vitaminology 55(1), 92-98, 2009-02
… We applied our newly developed FOX method to the assay of human 15-lipoxygenase-2 (15-LOX-2) and soybean lipoxygenase (SLOX) as typical animal and plant lipoxygenases, respectively. … The amounts of 15-S-hydroperoxyeicosa-5,8,10,14-tetraenoic acid (15-HPETE) produced by 15-LOX-2 measured by UV absorption at 237nm attributed to the conjugated diene, coincided with the results of our FOX method measuring absorbance at 610nm. …
NAID 110007110606

Effect of 15-Hydroperoxyeicosatetraenoic Acid on the Fibrinolytic Factor Release and the Antithrombin Binding of Vascular Endothelial Cells

Soeda Shinji,Honda Okinobu,Fujii Nobuaki [他],SHIMENO Hiroshi
Biological & pharmaceutical bulletin 20(1), 15-19, 1997-01-15
… 15-Hydroperoxyeicosatetraenoic acid (15-HPETE), an arachidonate lipoxygenase product, is reported to induce severe endothelial injury. … In this study, we examined the effect of 15-HPETE on the release of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) from cultured human umbilical vein endothelial cells (HUVEC). …
NAID 110003638923

松下洋一,松井隆尚,中山充
天然有機化合物討論会講演要旨集 (36), 212-219, 1994-09-20
… By the application of this reductive oxygenation, we attempted total syntheses of natural products such as antibiotic macrolide (-)-pyrenophorin (1), antioxidant phenol (2) and the related furans (3) isolated from Ginger, 15-HPETE (4), cytotoxic fatty acid (5) isolated from Corn, and furanoid fatty acid (6) (Fig. 1). …
NAID 110006679293